正中神经断裂伤晚期修复58例远期疗效

目的：通过对晚期神经损伤修复远期疗效观察，验证晚期神经损伤修复后能否获得满意的功能恢复。方法：对伤后１～１４年修复的５８例正中神经断裂伤，经１０年８个月长期观察，按国际统一标准评定疗效。结果：５８例中恢复优良３０例，占５１．７％。结论：伤后１年以上的晚期周围神经损伤的修复仍可获得较满意的恢复。     

对液化石油气燃烧产物接触者尿致突变性的研究

应用鼠伤寒沙门菌株ＴＡ９８及其新的衍生菌株ＹＧ１０２１和ＹＧ１０２４检测了液化石油气（ＬＰＧ）燃烧产物接触者尿的致突变性。吉果表明，在有大鼠Ｓ_９已β－葡萄糖醛酸酶存在时，尿样显示较强的致突变性。尿样对ＹＧ１０２４的致突变性明显高于ＴＡ９８，而对ＹＧ１０２１的致突变性与ＴＡ９８相近。提示ＬＰＧ燃烧产物接触者尿中致突变物主要是以葡萄糖醛酸贰结合状态存在的芳香胺类物质。同时也证明ＹＧ１０２４在检测该尿样的致突变性上比ＴＡ９８更为敏感。     

Extra-hepatic biliary tract metastases from breast cancer

A retrospective review was conducted of 49 breast cancer patients who were seen at the Massachusetts General Hospital from 1962 to 1978 and who developed biliary tract metastases. Although these findings were incidental at autopsy in 21 patients, clinical evidence of extra-hepatic biliary involvement developed in 28. This was documented radiographically, surgically, and/or confirmed at autopsy. Although most patients had previous or concurrent nonbiliary tract metastases, in 6 patients the initial site of failure was in the extra-hepatic biliary system. Analysis of the 28 patients in the clinical group revealed that initial management with radiation therapy alone produced a response in 3 of 6 patients. However, when radiation was coupled with bypass surgery and/or adjuvant chemotherapy, a response occurred in 3 of 3; the total radiation therapy response rate was 6/9. Chemotherapy given either alone or in combination with surgery produced a response in only one of 7 patients. All 4 irradiated patients who were treated with a time-dose-fractionation (TDF) > 40 had a complete response compared to a complete response in only 2 of 8 with a TDF ≤ 40. The median survival of the irradiated group was 6 months compared to 3.3 months in the treated-unirradiated patients and 0.7 months in the untreated patients. The onset of jaundice in a breast cancer patient does not necessarily indicate progressive hepatic involvement. Patients with extrahepatic metastatic obstruction are being recognized increasingly and should be treated vigorously, especially since such patients with no liver parenchymal involvement have a greater survival (median 6 months) than those with liver involvement (median 1.8 months).     

温莪术成分的研究

温莪术Curcuma aromatica Salise,浙江省温州地区产。临床及动物试验证明,其挥发油有一定抗癌作用。许洪霞等,已从温莪术油得到莪术醇(Curcumol)和莪术双酮(Gurdione),为了阐明有效成分,我们对其他成分进行了研究。文献报道的成分还有姜黄烯(Curcumene),姜醇(Zingiberol),α及β-蒎烯(Pinene),樟烯(Camphene),薁(azulene),樟脑(Camphor),姜烯(Zingiberene)α-松油醇(α-terpineol),d-龙脑(d-borneol),对-异丙基苄醇,对-甲氧基肉桂酸等。我们初步分离鉴定下列成分:α-蒎烯,β-蒎烯,樟烯,桉叶油素(1,8-cineol),龙脑,异龙脑、樟脑、吉马酮(Germacrone),异呋吉马烯(isofuranogermacrene)和四甲基吡嗪(tetramethylpyrazine)等。