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排序方式: 共有4167条查询结果,搜索用时 15 毫秒
91.
Noriko Komatsu Stephanie Win Minglu Yan Nam Cong-Nhat Huynh Shinichiro Sawa Masayuki Tsukasaki Asuka Terashima Warunee Pluemsakunthai George Kollias Tomoki Nakashima Hiroshi Takayanagi 《The Journal of clinical investigation》2021,131(6)
In rheumatoid arthritis (RA), osteoclastic bone resorption causes structural joint damage as well as periarticular and systemic bone loss. Periarticular bone loss is one of the earliest indices of RA, often preceding the onset of clinical symptoms via largely unknown mechanisms. Excessive osteoclastogenesis induced by receptor activator of NF-κB ligand (RANKL) expressed by synovial fibroblasts causes joint erosion, whereas the role of RANKL expressed by lymphocytes in various types of bone damage has yet to be elucidated. In the bone marrow of arthritic mice, we found an increase in the number of RANKL-expressing plasma cells, which displayed an ability to induce osteoclastogenesis in vitro. Genetic ablation of RANKL in B-lineage cells resulted in amelioration of periarticular bone loss, but not of articular erosion or systemic bone loss, in autoimmune arthritis. We also show conclusive evidence for the critical contribution of synovial fibroblast RANKL to joint erosion in collagen-induced arthritis on the arthritogenic DBA/1J background. This study highlights the importance of plasma-cell RANKL in periarticular bone loss in arthritis and provides mechanistic insight into the early manifestation of bone lesion induced by autoimmunity. 相似文献
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93.
Susumu Morita Satoru Joshita Takeji Umemura Yoshihiko Katsuyama Takefumi Kimura Michiharu Komatsu Akihiro Matsumoto Kaname Yoshizawa Astushi Kamijo Nobuyoshi Yamamura Eiji Tanaka Masao Ota 《Human immunology》2013
Primary biliary cirrhosis (PBC) is characterized by portal inflammation and immune-mediated destruction of intrahepatic bile ducts that often result in liver failure. Toll-like receptor (TLR) 4 recognizes lipopolysaccharides of Gram-negative bacteria. Infectious agents have been suspected to play a crucial role in PBC pathogenesis since TLR4 expression was found in bile duct epithelial cells and periportal hepatocytes in liver tissues of PBC. To assess the potential contribution of TLR4 SNPs to the development of this disease, we genotyped five SNPs in TLR4 in 261 PBC patients and 359 controls using a TaqMan assay. No significant positive associations with either PBC susceptibility or progression were uncovered. These results indicate that TLR4 polymorphisms do not play a prominent role in the development of PBC in Japanese patients. 相似文献
94.
Ken Komatsu Masayoshi Hashimoto Yukari Okano Takuya Keima Yugo Kitazawa Takamichi Nijo Shuichiro Takahashi Kensaku Maejima Yasuyuki Yamaji Shigetou Namba 《Archives of virology》2013,158(7):1579-1582
Radish mosaic virus (RaMV) is a crucifer-infecting comovirus that has been detected worldwide. Here, we report the successful construction of a full-length infectious cDNA clone of RaMV. The full-length cDNA clones corresponding to RNA1 and RNA2 of a Japanese isolate of RaMV were cloned into the pBlueScript plasmid or the binary vector pCAMBIA1301 downstream of the cauliflower mosaic virus 35S promoter. Mechanical inoculation or agroinoculation of Nicotiana benthamiana with these vectors resulted in systemic RaMV infections causing symptoms similar to those caused by the wild-type parental virus. The presence of progeny virus was verified by western blot analysis and electron microscopy. 相似文献
95.
Shiraishi Tomotaka Umehara Tadashi Oka Hisayoshi Nakahara Atsuo Sato Takeo Matsuno Hiromasa Komatsu Teppei Omoto Shusaku Murakami Hidetomo Iguchi Yasuyuki 《Clinical autonomic research》2021,31(3):425-431
Clinical Autonomic Research - Delayed orthostatic hypotension (DOH), a fall in blood pressure after a 3-min cutoff, is clinically meaningful. The aim of this study was to elucidate the clinical and... 相似文献
96.
Hirota Yoshiaki Tawada Yasuyuki Komatsu Shigeki Watanabe Fumihiko 《Odontology / the Society of the Nippon Dental University》2021,109(1):157-167
Odontology - Oral scanners allow dental impressions to be taken in a short time without the use of an impression material. However, it has been noted that high impression accuracy cannot be... 相似文献
97.
Toume Kazufumi Hou Zhiyan Yu Huanhuan Kato Mitsuru Maesaka Miki Bai Yanjing Hanazawa Shiho Ge Yuewei Andoh Tsugunobu Komatsu Katsuko 《Journal of natural medicines》2020,74(3):615-615
Journal of Natural Medicines - The article Search of anti-allodynic compounds from Plantaginis Semen, a crude drug ingredient of Kampo formula “Goshajinkigan”. 相似文献
98.
Batsukh Zolboo Toume Kazufumi Javzan Batkhuu Kazuma Kohei Cai Shao-Qing Hayashi Shigeki Kawahara Nobuo Maruyama Takuro Komatsu Katsuko 《Journal of natural medicines》2020,74(1):170-188
Journal of Natural Medicines - Saposhnikoviae Radix (SR) is a commonly used crude drug that is obtained from the root and rhizome of Saposhnikovia divaricata which is distributed throughout China,... 相似文献
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100.