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Materials and methods: We exposed male C57BL/6 mice to 0.5 and 1.0?Gy proton total body irradiation (proton-TBI, 150?MeV) and examined changes in peripheral blood cells and bone marrow (BM) progenitors and LSK cells 2 weeks after exposure.
Results: 1.0?Gy proton-TBI significantly reduced the numbers of peripheral blood cells compared to 0.5?Gy proton-TBI and unirradiated animals, while the numbers of peripheral blood cell counts were comparable between 0.5?Gy proton-TBI and unirradiated mice. The frequencies and numbers of LSK cells and CMPs in BM of 0.5 and 1.0?Gy irradiated mice were decreased in comparison to those of normal controls. LSK cells and CMPs and their progeny exhibited a radiation-induced impairment in clonogenic function. Exposure to 1.0?Gy increased cellular apoptosis but not the production of reactive oxygen species (ROS) in CMPs two weeks after irradiation. LSK cells from irradiated mice exhibited an increase in ROS production and apoptosis.
Conclusion: Exposure to proton-TBI can induce acute damage to BM progenitors and LSK cells. 相似文献