全文获取类型
收费全文 | 2073篇 |
免费 | 93篇 |
国内免费 | 22篇 |
专业分类
耳鼻咽喉 | 13篇 |
儿科学 | 24篇 |
妇产科学 | 24篇 |
基础医学 | 192篇 |
口腔科学 | 18篇 |
临床医学 | 94篇 |
内科学 | 664篇 |
皮肤病学 | 22篇 |
神经病学 | 141篇 |
特种医学 | 128篇 |
外科学 | 256篇 |
综合类 | 4篇 |
预防医学 | 58篇 |
眼科学 | 31篇 |
药学 | 73篇 |
中国医学 | 4篇 |
肿瘤学 | 442篇 |
出版年
2023年 | 18篇 |
2022年 | 32篇 |
2021年 | 72篇 |
2020年 | 31篇 |
2019年 | 53篇 |
2018年 | 52篇 |
2017年 | 35篇 |
2016年 | 60篇 |
2015年 | 59篇 |
2014年 | 71篇 |
2013年 | 84篇 |
2012年 | 132篇 |
2011年 | 144篇 |
2010年 | 85篇 |
2009年 | 89篇 |
2008年 | 128篇 |
2007年 | 138篇 |
2006年 | 126篇 |
2005年 | 121篇 |
2004年 | 118篇 |
2003年 | 100篇 |
2002年 | 110篇 |
2001年 | 22篇 |
2000年 | 25篇 |
1999年 | 20篇 |
1998年 | 22篇 |
1997年 | 28篇 |
1996年 | 20篇 |
1995年 | 18篇 |
1994年 | 26篇 |
1993年 | 22篇 |
1992年 | 15篇 |
1991年 | 14篇 |
1990年 | 10篇 |
1989年 | 10篇 |
1988年 | 7篇 |
1987年 | 7篇 |
1986年 | 7篇 |
1985年 | 2篇 |
1982年 | 6篇 |
1981年 | 6篇 |
1980年 | 5篇 |
1979年 | 7篇 |
1978年 | 5篇 |
1977年 | 3篇 |
1976年 | 2篇 |
1974年 | 4篇 |
1973年 | 3篇 |
1967年 | 2篇 |
1927年 | 5篇 |
排序方式: 共有2188条查询结果,搜索用时 15 毫秒
31.
Masaharu Ishihara Ichiro Inoue Takuji Kawagoe Yuji Shimatani Satoshi Kurisu Takaki Hata Yasuharu Nakama Yasufumi Kijima Eisuke Kagawa 《European heart journal》2006,27(20):2413-2419
AIMS: To investigate whether admission hyperglycaemia in non-diabetic patients with acute myocardial infarction (AMI) is a surrogate for previously undiagnosed abnormal glucose tolerance. METHODS AND RESULTS: Two hundred non-diabetic patients with AMI were divided into three groups: 81 patients with admission glucose < 7.8 mmol/L (group 1), 83 patients with admission glucose > or = 7.8 mmol/L and < 11.1 mmol/L (group 2), and 36 patients with admission glucose > or = 11.1 mmol/L (group 3). Abnormal glucose tolerance, diabetes, or impaired glucose tolerance (IGT) was diagnosed by oral glucose tolerance test (OGTT). OGTT identified diabetes in 53 patients (27%) and IGT in 78 patients (39%). When the fasting glucose criteria were applied, however, only 14 patients (7%) were diagnosed as having diabetes. The prevalence of abnormal glucose tolerance was similar among the three groups: 67% in group 1, 63% in group 2, and 69% in group 3 (P = 0.74). The relation of fasting glucose (r2 = 0.50, P < 0.001) and HbA1c (r2 = 0.34, P < 0.001) to 2-h post-load glucose was significant, but the relation of admission glucose to 2-h post-load glucose was not significant (r2 = 0.02, P = 0.08). Multivariable analysis showed that fasting glucose and HbA1c were independent predictors of abnormal glucose tolerance, but admission glucose was not. CONCLUSION: Admission hyperglycaemia in non-diabetic patients with AMI does not represent previously undiagnosed abnormal glucose tolerance. Fasting glucose and HbA1c, rather than admission glucose, may be useful to predict abnormal glucose tolerance. However, these parameters lacked sensitivity. OGTT should be considered in all non-diabetic patients with AMI. 相似文献
32.
Four types of Ipsilateral Breast Tumor Recurrence (IBTR) after breast‐conserving surgery: Classification of IBTR based on precise pathological examination 下载免费PDF全文
Takehiko Sakai Seiichiro Nishimura Akiko Ogiya Masahiko Tanabe Kiyomi Kimura Hidetomo Morizono Kotaro Iijima Yumi Miyagi Masujiro Makita Yoshinori Ito Masahiko Oguchi Rie Horii Futoshi Akiyama Takuji Iwase 《Pathology international》2015,65(3):113-118
We classified ipsilateral breast tumor recurrences (IBTRs) based on strict pathological rules. Ninety‐six women who were surgically treated for IBTR were included. IBTRs were classified according to their origins and were distinguished based on strict pathological rules: relationship between the IBTR and the primary lumpectomy scar, surgical margin status of the primary cancer, and the presence of in situ lesions of IBTR. The prognosis of these subgroups were compared to that of new primary tumors (NP) in the narrow sense (NPn) that occurred far from the scar. Distant‐disease free survival of IBTR that occurred close to the scar with in situ lesions and a negative surgical margin of the primary cancer (NP occurred close to the scar, NPcs) was similar to that of NPn. In contrast, IBTR that occurred close to the scar without in situ lesions (true recurrence (TR) that arose from residual invasive carcinoma foci, TRinv) had significantly poorer prognosis than NPn. IBTR that occurred close to the scar with in situ lesions and a positive surgical margin of the primary cancer (TR arising from a residual in situ lesion, TRis) had more late recurrences than NPcs. Precise pathological examinations indicated four distinct IBTR subtypes with different characteristics. 相似文献
33.
Okusaka Takuji Ikeda Kenji Kudo Masatoshi Finn Richard Qin Shukui Han Kwang-Hyub Cheng Ann-Lii Piscaglia Fabio Kobayashi Masahiro Sung Max Chen Minshan Wyrwicz Lucjan Yoon Jung-Hwan Ren Zhenggang Mody Kalgi Dutcus Corina Tamai Toshiyuki Ren Min Hayato Seiichi Kumada Hiromitsu 《Journal of gastroenterology》2021,56(6):570-580
Journal of Gastroenterology - REFLECT was an open-label, phase 3 study comparing the efficacy and safety of lenvatinib versus sorafenib in patients with unresectable hepatocellular carcinoma... 相似文献
34.
35.
Kurisu S Inoue I Kawagoe T Ishihara M Shimatani Y Mitsuba N Hata T Nakama Y Kisaka T Kijima Y 《Internal medicine (Tokyo, Japan)》2004,43(12):1157-1161
A 28-year-old man was admitted because of chest pain. Emergency coronary angiography showed a massive thrombus in the proximal segment and another occlusive thrombus in the distal segment of the left anterior descending artery. He was treated with thrombolytic therapy. Repeat coronary angiography showed disappearance of the thrombi in the proximal and distal segments and obvious myocardial bridging in the mid segment. Intravascular ultrasound revealed an atherosclerotic plaque in the segment immediately proximal to the myocardial bridging, but did not reveal any plaque within or distal to the site. He was discharged 12 days later. 相似文献
36.
Takuji Toyama Hiroshi Hoshizaki Ryotaro Seki Naoki Isobe Hitoshi Adachi Shigeto Naito Shigeru Oshima Koichi Taniguchi 《Circulation journal》2004,68(4):348-354
BACKGROUND: GIK-201Tl imaging reportedly improves the detection of viable myocardium, so the present study evaluated whether it can detect myocardial viability after acute myocardial infarction (AMI). METHODS AND RESULTS: Resting 201Tl and 99mTc-pyrophosphate (PYP) dual single photon emission computed tomography (SPECT) and 201Tl SPECT after 201Tl with GIK (10% glucose, insulin 5 U, and KCl 10 mmol) infusion (GIK-201Tl) were performed in 25 AMI patients within 10 days of admission. GIK-201Tl SPECT images were obtained immediately and 4 h after infusion. Left ventriculography (LVG) was performed within 3 weeks and at 6 months when follow-up 201Tl SPECT was also performed. From 20 SPECT segments, both the summed defect score (RDS) and the number of defect segments (ES) were calculated. The infarcted area was defined as 99mTc-PYP uptake segments. Wall motion was estimated in 7 LVG segments. The ES of R-201Tl (5.5 +/- 2.8), immediate GIK-201Tl (4.0 +/- 2.3), and 4-h GIK-201Tl (5.6 +/- 2.7) were lower than that of 99mTc-PYP (7.5 +/- 4.1) (p<0.05), and the ES had significantly declined 6 months later on 201Tl (3.5 +/- 2.8) (p<0.05). Although the RDS of R-201Tl (11.3 +/- 7.9) and 4-h GIK-201Tl (11.2 +/- 6.3) were greater than at the 6-month 201Tl (7.1 +/- 6.5), immediate GIK-201Tl (7.4 +/- 6.5) was equivalent to follow-up 201Tl. The sensitivity of immediate GIK-201Tl was highest among the imaging methods. CONCLUSION: To detect myocardial viability after AMI, early imaging with GIK-201Tl is more useful than resting 201Tl imaging. 相似文献
37.
Junki Mizusawa Akira Fukutomi Hiroshi Katayama Hiroshi Ishii Tatsuya Ioka Takuji Okusaka Hideki Ueno Makoto Ueno Masafumi Ikeda Nobumasa Mizuno Masato Ozaka Haruhiko Fukuda Junji Furuse 《Pancreatology》2018,18(7):841-845
Gemcitabine is one of the standard treatments for locally advanced pancreatic cancer. Recent studies on metastatic pancreatic cancer have shown that combination chemotherapy with oxaliplatin, irinotecan, fluorouracil, and leucovorin (FOLFIRINOX) and gemcitabine plus nab-paclitaxel (GnP) prolonged the overall survival compared with gemcitabine alone. To select the most promising chemotherapy, a randomized phase II selection design trial was started in July 2016 to compare between modified FOLFIRINOX and GnP for patients with locally advanced pancreatic cancer. A total of 124 patients will be enrolled from 36 Japanese institutions within 2.5 years. The primary endpoint is the proportion of 1-year overall survival, and secondary endpoints are progression-free survival, distant metastasis-free survival, response rate in patients with target lesions, CA19-9 response, adverse events, treatment-related death, early death, grade 4 non-hematological toxicity, and dose intensity. This trial has been registered with the UMIN Clinical Trials Registry [http://www.umin.ac.jp/ctr/index.htm], and the registration number is UMIN000023143. 相似文献
38.
Takuji Masunaga 《Connective tissue research》2013,54(2):55-66
The epidermal basement membrane is a specialized structure localized between the epidermis and the dermis. Recent studies have elucidated the biological roles of the basement membrane and its pathophysiological involvement in bullous diseases. To understand the functions of the basement membrane, it is essential to have clear and precise information regarding the ultrastructural molecular organization of the epidermal basement membrane. Immunoelectron microscopy is a powerful technique and the only method available for the clarification of the ultrastructural localization or orientation of molecules. This review summarizes the latest information regarding the molecular organization of the epidermal basement membrane as determined by immunoelectron microscopy as well as the blistering diseases that occur in the epidermal basement membrane zone. 相似文献
39.
Daisuke Tajima Takuji Nakamura Fumio Ichinose Nobuhiko Okamoto Yuko Tomonoh Keiko Uda Rie Furukawa Katsuya Tashiro Muneaki Matsuo 《Brain & development》2021,43(3):482-485
Paroxysmal abnormal eye movement in early infancy is one of the initial symptoms of glucose transporter 1 deficiency syndrome (GLUT1DS). We describe four early infants with transient hypoglycorrhachia presenting with abnormal eye movements. Their symptoms disappeared after the introduction of a ketogenic diet (KD), and their development was normal. Since no variants in SLC2A1 were detected, the CSF-to-blood glucose ratios (C/B) were re-examined, and within normal range. None of the four patients displayed recurrent symptoms after withdrawal from the KD. Because long-term KD has potential adverse effects and could affect the quality of life of patients and their families, re-examination of CSF glucose during late infancy should be considered in the case of absence of the SLC2A1 pathogenic variant. 相似文献
40.
Domae Keitaro Toda Koichi Yoshioka Daisuke Miyagawa Shigeru Yoshikawa Yasushi Hata Hiroki Kainuma Satoshi Kawamura Takuji Kawamura Ai Sawa Yoshiki 《Journal of artificial organs》2021,24(3):377-381
Journal of Artificial Organs - Infection is a major complication in patients with a left ventricular assist device (LVAD). Once a driveline exit-site infection (DLI) reaches the LVAD component,... 相似文献