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41.
Comparison between T1 relaxation time of Gd‐EOB‐DTPA‐enhanced MRI and liver stiffness measurement of ultrasound elastography in the evaluation of cirrhotic liver 下载免费PDF全文
42.
H. Takeda H. Kishikawa M. Shinohara T. Miyata K. Suzaki H. Fukushima K. Ichinose M. Shichiri 《Diabetologia》1988,31(9):657-663
Summary The role of epinephrine in platelet activation and the effect of an 2-adrenoceptor antagonist, midaglizole, during insulin-induced hypoglycaemia in Type 2 (noninsulin-dependent) diabetes mellitus were examined. The action of midaglizole as a platelet 2-antagonist was confirmed by in vitro studies using platelet-rich plasma and washed platelet suspension. Hypoglycaemia was induced by a bolus injection of short-acting insulin in 24 diabetic patients. They were divided into two groups, a control group (n=12) and an 2-group (n=12), and midaglizole was administered orally 60 min before insulin injection in the latter. Blood glucose and plasma C-peptide levels were significantly decreased (p<0.005) by insulin injection in both groups. Counter-regulatory hormones, including epinephrine, and arginine vasopressin were similarly increased at the hypoglycaemic nadir compared with the levels at 0 min in both groups. Plasma -thromboglobulin was increased at the hypoglycaemic nadir (165.5±12.6ng/ml) compared with the level at 0 min (121.0±11.5, p<0.005) in the control group, whereas no significant increase was demonstrated in the 2 group. These results suggest that plasma epinephrine plays an important role in platelet activation during hypoglycaemia in Type 2 diabetes mellitus, and that the platelet activation is prevented by 2-adrenoceptor antagonist. 相似文献
43.
Katsutoshi Obara Ken Haruma Atsushi Irisawa Mitsuru Kaise Takuji Gotoda Masanori Sugiyama Satoshi Tanabe Akira Horiuchi Naotaka Fujita Makoto Ozaki Masahiro Yoshida Toshiyuki Matsui Masao Ichinose Michio Kaminishi 《Digestive endoscopy》2015,27(4):435-449
Recently, the need for sedation in gastrointestinal endoscopy has been increasing. However, the National Health Insurance Drug Price list in Japan does not include any drug specifically used for the sedation. Although benzodiazepines are the main medication, their use in cases of gastrointestinal endoscopy has not been approved. This has led the Japan Gastrointestinal Endoscopy Society to develop the first set of guidelines for sedation in gastrointestinal endoscopy on the basis of evidence‐based medicine in collaboration with the Japanese Society for Anesthesiologists. The present guidelines comprise 14 statements, five of which were judged to be valid on the highest evidence level and three on the second highest level. The guidelines are not intended to strongly recommend the use of sedation for gastrointestinal endoscopy, but rather to indicate the policy as to the choice of appropriate procedures when such sedation is deemed necessary. In clinical practice, the final decision as to the use of sedation should be made by physicians considering patient willingness and physical condition. 相似文献
44.
Yasunobu Yamashita MD Jun Kato MD PhD Kazuki Ueda MD PhD Yasushi Nakamura MD PhD Hiroko Abe MD Takashi Tamura MD Masahiro Itonaga MD Takeichi Yoshida MD PhD Hiroki Maeda MD Kosaku Moribata MD PhD Toru Niwa MD PhD Takao Maekita MD PhD Mikitaka Iguchi MD PhD Hideyuki Tamai MD PhD Masao Ichinose MD PhD 《Journal of clinical ultrasound : JCU》2015,43(2):89-97
45.
Nakasone N Tran HH Nguyen MB Higa N Toma C Song T Ichinose Y Iwanaga M 《The American journal of tropical medicine and hygiene》2005,73(3):586-587
Enterohemorrhagic Escherichia coli O157:H7 was isolated for the first time in Vietnam. Shiga toxin-producing E. coli were isolated from 8 of 100 cows examined. The two strains showing serotype O157:H7 carried the eae, ehxA, and stx2c genes, but the other six were negative for the eae gene. 相似文献
46.
Yohei Kawaguchi Masayuki Nakao Kenshiro Omura Naoya Iwamoto Hiroki Ozawa Yasuto Kondo Junji Ichinose Yosuke Matsuura Sakae Okumura Mingyon Mun 《Journal of thoracic disease》2020,12(12):7218
BackgroundIt is critical to have an accurate measurement of solid tumor size in order to predict the invasiveness of small lung adenocarcinomas. Some lesions cannot be measured accurately via High-resolution computed tomography (HRCT) due to their irregular shape and unclear borders. For this reason, we evaluated the relative efficacy of three-dimensional (3D) CT for predicting invasive adenocarcinoma.MethodsWe evaluated 195 patients with clinical stage IA adenocarcinomas, including 109 with lesions documented as invasive that were surgically resected at our institute during 2017. All lesions were categorized as either (I) lesions that were difficult to evaluate (i.e., hazy lesions; HL) or (II) more typical lesions (TL). The relationships between solid tumor size as determined by HRCT, solid tumor volume as determined by 3D CT and pathologic diagnosis were evaluated.ResultsFifty-seven patients (29%) were diagnosed with HL. We set the cut-off value for the solid volume at 225 mm3 as predictive for invasive adenocarcinoma. When evaluating all 195 patients as a group, the accuracy, sensitivity, and specificity based on the solid tumor volume were similar to those based on the solid tumor size. When we limit our analysis to the HL group, the specificity based on solid tumor volume (65.5%) was higher than that based on solid tumor size (44.8%) with a difference that approached statistical significance (P=0.070).Conclusions3D CT was equivalent to HRCT for predicting invasive adenocarcinoma and may be particularly useful for diagnosing lesions that are difficult to evaluate on HRCT. 相似文献
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49.
Ichinose K Origuchi T Kawashiri SY Iwamoto N Fujikawa K Aramaki T Kamachi M Arima K Tamai M Nakamura H Ida H Kawakami A Eguchi K 《Rheumatology international》2012,32(2):483-487
We present six cases of patients with Japanese rheumatoid arthritis (RA) treated with a tumor necrosis factor (TNF)-alpha blocking agent, adalimumab as monotherapy for 220?weeks. All six patients were women, and the median age was 54.0?±?7.07?years old. The median duration of the disease was 7.43?±?11.1?years, and the median disease activity score (DAS28-CRP) was 5.35?±?0.69. Three of six patients were able to continue to receive this treatment for 220?weeks successfully, and the DAS28-CRP decreased to 1.89?±?0.75. Two patients withdrew because of lack of efficacy, and one patient withdrew because of adverse events (non-Hodgkin lymphoma). Adalimumab resulted in a sustained clinical response in RA patients during 220-week follow-up. 相似文献
50.
Yamanaka K Hatano E Kitamura K Iida T Ishii T Machimito T Taura K Yasuchika K Isoda H Shibata T Uemoto S 《Journal of gastroenterology》2012,47(3):343-346