全文获取类型
收费全文 | 8947篇 |
免费 | 455篇 |
国内免费 | 81篇 |
专业分类
耳鼻咽喉 | 39篇 |
儿科学 | 158篇 |
妇产科学 | 192篇 |
基础医学 | 1420篇 |
口腔科学 | 215篇 |
临床医学 | 541篇 |
内科学 | 2137篇 |
皮肤病学 | 285篇 |
神经病学 | 668篇 |
特种医学 | 320篇 |
外科学 | 1354篇 |
综合类 | 36篇 |
一般理论 | 1篇 |
预防医学 | 229篇 |
眼科学 | 105篇 |
药学 | 644篇 |
中国医学 | 18篇 |
肿瘤学 | 1121篇 |
出版年
2023年 | 38篇 |
2022年 | 116篇 |
2021年 | 176篇 |
2020年 | 92篇 |
2019年 | 145篇 |
2018年 | 185篇 |
2017年 | 178篇 |
2016年 | 200篇 |
2015年 | 197篇 |
2014年 | 282篇 |
2013年 | 319篇 |
2012年 | 522篇 |
2011年 | 587篇 |
2010年 | 356篇 |
2009年 | 282篇 |
2008年 | 486篇 |
2007年 | 567篇 |
2006年 | 568篇 |
2005年 | 579篇 |
2004年 | 552篇 |
2003年 | 571篇 |
2002年 | 548篇 |
2001年 | 147篇 |
2000年 | 128篇 |
1999年 | 158篇 |
1998年 | 142篇 |
1997年 | 92篇 |
1996年 | 84篇 |
1995年 | 85篇 |
1994年 | 80篇 |
1993年 | 70篇 |
1992年 | 91篇 |
1991年 | 101篇 |
1990年 | 87篇 |
1989年 | 93篇 |
1988年 | 75篇 |
1987年 | 65篇 |
1986年 | 56篇 |
1985年 | 52篇 |
1984年 | 43篇 |
1983年 | 27篇 |
1982年 | 36篇 |
1981年 | 15篇 |
1980年 | 23篇 |
1979年 | 30篇 |
1978年 | 18篇 |
1977年 | 14篇 |
1976年 | 13篇 |
1974年 | 14篇 |
1973年 | 15篇 |
排序方式: 共有9483条查询结果,搜索用时 0 毫秒
11.
Q-Switched Alexandrite Laser Therapy for Pigmentation of the Lips Owing to Laugier-Hunziker Syndrome 总被引:2,自引:0,他引:2
Ozawa Toshiyuki MD Fujiwara Masao MD † Harada Teruichi MD Muraoka Michinari MD Ishii Masamitsu MD 《Dermatologic surgery》2005,31(6):709-712
BACKGROUND: Laugier-Hunziker (LH) syndrome is a rare benign condition in which hyperpigmentation of the lips and buccal mucosa occurs with no systemic associations. OBJECTIVE: We report the response to treatment with the Q-switched alexandrite laser (QSAL) because there are few reports on therapy for LH syndrome. METHODS: The QSAL was used for pigmentation of the lips in a 63-year-old woman with LH syndrome. Laser irradiation was done at 5.0 J/cm2 with a 3 mm spot size. RESULTS: There was 100% clearance of pigmentation of the lips with a single laser treatment, and recurrence was not observed after 6 months. CONCLUSION: The QSAL is very effective for pigmentation owing to LH syndrome. 相似文献
12.
Yoshihiro Kokubo Hitonobu Tomoike Chihiro Tanaka Mariko Banno Tomohiko Okuda Nozomu Inamoto Kei Kamide Yuhei Kawano Toshiyuki Miyata 《Hypertension research》2006,29(8):611-619
We previously selected a group of hypertension candidate genes by a key word search using the OMIM database of NCBI and validated 525 coding single nucleotide polymorphisms (SNPs) in 179 hypertension candidate genes by DNA sequencing in a Japanese population. In the present study, we examined the association between 61 non-synonymous SNPs and blood pressure variations and hypertension. We used DNA samples taken from 1,880 subjects in the Suita study, a population-based study using randomly selected subjects. Analyses of covariance adjusting for age, body mass index, hyperlipidemia, diabetes, smoking, drinking, and antihypertensive medication revealed that 17 polymorphisms in 16 genes (APOB, CAST, CLCNKB, CTNS, GHR, GYS1, HF1, IKBKAP, KCNJ11, LIPC, LPL, P2RY2, PON2, SLC4A1, TRH, VWF) were significantly associated with blood pressure variations. Multivariate logistic regression analysis with adjustment for the same factors revealed that 11 polymorphisms in 11 genes (CAST, CTLA4, F5, GC, GHR, LIPC, PLA2G7, SLC4A1, SLCI8A1, TRH, VWF) showed significant associations with hypertension. Five polymorphisms in five genes, CAST(calpastatin), LIPC (hepatic lipase), SLC4A1 (band 3 anion transporter), TRH (thyrotropin-releasing hormone), and VWF (von Willebrand factor), were significantly associated with both blood pressure variation and hypertension. Thus, our study suggests that these five genes were susceptibility genes for essential hypertension in this Japanese population. 相似文献
13.
14.
Hironari Takaishi Osamu Nemoto Masanobu Shiota Toshiyuki Kikuchi Harumoto Yamada Masaaki Yamagishi Yutaka Yabe 《Journal of orthopaedic research》1997,15(4):528-538
To clarify phenotypic alterations of intervertebral disc cells during the repair process, we cloned partial type-II collagen cDNA from rabbits and analyzed the level of expression of type-II collagen mRNA in disc degeneration. An animal model was created by surgical denucleation of rabbit intervertebral discs through, an extraperitoneal approach. Eight animals each from an experimental and a control group were killed at 2, 4, 8, or 16 weeks postoperatively, and the disc samples were used for this study. Round chondrorcyte-like cells that filled the herniated space showed intense signal of type-II collagen mRNA and significant pericellular immunostaining of type-II collagen but no clear staining of type-I collagen. Northern. blot analysis revealed that the expression of type-II collagen mRNA of the repair disc cells was transiently increased at 4 weeks postoperatively. The cells were able to change their morphology in response to mechanical stimulation by surgical denucleation and to induce a significant increase in the gene expression of type-II collagen at an early phase of disc degeneration. The present results indicate the transient enhancement of repair activity in the degenerative process of injured fibrocartilage. 相似文献
15.
Kousaku Matsubara M.D. Kei Suzuki M.D. Ying Wei Lin M.D. Toshiyuki Yamamoto M.D. Shigeru Ohta M.D. 《Pediatrics international》1991,33(4):482-487
We present two female siblings with familial juvenile nephronophthisis (FJN) which was diagnosed at the early stage of renal failure. Diagnosis was made during the investigation of anemia in case 1 and by a subsequent family survey in case 2. Most patients with FJN are not identified until the terminal stage of renal failure and such cases have rarely been reported in Japan. Case 2 had a reduction in the maximum urinary concentration ability but no azotemia, and among the FJN patients reported in Japan so far she has the least advanced renal disease. Histological examination of the renal biopsy in case 1 showed typical findings of FJN, such as thickening and lamination of the tubular basement membrane (TBM), interstitial fibrosis, and round cell infiltration of the interstitium. In case 2, renal biopsy revealed an irregular marked thickening of the TBM with trivial interstitial changes and a normal glomerular appearance. The histology of these two cases suggests that the TBM may be the primary site affected in FJN. 相似文献
16.
Extracardiac Direct Total Cavopulmonary Connection 总被引:2,自引:0,他引:2
Masaaki Yamagishi MD Yuzuru Nakamura MD Toshiyuki Kanazawa MD Noriyasu Kawada MD 《The Annals of thoracic surgery》1997,64(6):1817-1819
We report a successful extracardiac direct total cavopulmonary connection without prosthetic materials performed in a 3-year-old boy with tricuspid atresia, infundibular pulmonary stenosis, and normally positioned great arteries. The transected pulmonary trunk was bought down posterolaterally with respect to the right atrium and was anastomosed end-to-end with the inferior vena cava. 相似文献
17.
Radiotherapy was applied to 14 esophageal carcinomas with respiratory tract fistulas using various treatment regimens. Closure of the fistulas was observed in four cases after irradiation at a daily dose of 1.5 Gy. The period of closure was transient in two cases but long-term in the other two. One long-term closure case underwent low-dose rate telecobalt therapy (LDRT)(1 Gy per hour, 7 Gy per day; a total dose of 28 Gy) as a boost. His cancer has been well controlled and he is still alive without recurrence at 74 months after fistula formation. 相似文献
18.
19.
Toshiyuki Matsui Sumio Tsuda Hiroaki Matake Keisuke Ikeda Tsuneyoshi Yao 《Digestive endoscopy》2004,16(Z1):S27-S30
Background: Gastrointestinal strictures are the most often and serious complication in Crohn's disease. Because of the frequent postoperative recurrence in Crohn's disease, endoscopic therapy of gastrointestinal stricture is one of the best therapeutic options. Method: The present study sets out the results from a prospective study of endoscopic dilation therapy on 48 Crohn's disease patients with severe gastrointestinal stenoses. All patients who could not undergo endoscopic balloon dilation therapy (EBD) were operated on. Results: Long‐term success was attained in 32 of the 48 patients; cumulative avoidance of surgery after EBD was 86% at one year and 71% at three. Second, the most hazardous factor was recurrent inflammation causing restenosis. Patients who had strictures with oral luminal dilatation and patients with frequent recurrence had a tendency to be operated on. As a complication, perforation occurred in two cases (3.3%). Conclusions: EBD therapy for Crohn's stricture in the gastrointestinal tract is recommended before surgical intervention. 相似文献
20.