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61.
62.
In situ hybridisation study of type I, II, X collagens and aggrecan mRNAs in the developing condylar cartilage of fetal mouse mandible 总被引:1,自引:1,他引:0
KENJI FUKADA SHUNICHI SHIBATA SHOICHI SUZUKI KEIICHI OHYA TAKAYUKI KURODA 《Journal of anatomy》1999,195(3):321-329
The aim of this study was to investigate the developmental characteristics of the mandibular condyle in sequential phases at the gene level using in situ hybridisation. At d 14.5 of gestation, although no expression of type II collagen mRNA was observed, aggrecan mRNA was detected with type I collagen mRNA in the posterior region of the mesenchymal cell aggregation continuous with the ossifying mandibular bone anlage prior to chondrogenesis. At d 15.0 of gestation, the first cartilaginous tissue appeared at the posterior edge of the ossifying mandibular bone anlage. The primarily formed chondrocytes in the cartilage matrix had already shown the appearance of hypertrophy and expressed types I, II and X collagens and aggrecan mRNAs simultaneously. At d 16.0 of gestation, the condylar cartilage increased in size due to accumulation of hypertrophic chondrocytes characterised by the expression of type X collagen mRNA, whereas the expression of type I collagen mRNA had been reduced in the hypertrophic chondrocytes and was confined to the periosteal osteogenic cells surrounding the cartilaginous tissue. At d 18.0 of gestation before birth, cartilage-characteristic gene expression had been reduced in the chondrocytes of the lower half of the hypertrophic cell layer. The present findings demonstrate that the initial chondrogenesis for the mandibular condyle starts continuous with the posterior edge of the mandibular periosteum and that chondroprogenitor cells for the condylar cartilage rapidly differentiate into hypertrophic chondrocytes. Further, it is indicated that sequential rapid changes and reductions of each mRNA might be closely related to the construction of the temporal mandibular ramus in the fetal stage. 相似文献
63.
Akiyoshi KITAJIMA Nobuto SHIBATA Tohru OHNUMA Shinji HIGASHI Taku OHKUBO Chie USUI Tomoko WATANABE Ritsuko KAWASHIMA Mieko OHTSUKA Akira UEKI Masatsugu NAGAO Heii ARAI 《Psychogeriatrics》2006,6(4):150-153
Background: Cholesteryl ester transfer protein regulates the plasma high density lipoprotein cholesterol level, which is considered to play an antiatherogenic role in humans. The presence of apolipoprotein E epsilon4 allele is a strong risk factor for developing Alzheimer’s disease (AD). Since apolipoprotein E is a regulator of lipid metabolism, it is reasonable to assume that lipids play important roles in the pathogenesis of AD. Methods: We studied the relationship between polymorphisms of the cholesteryl ester transfer protein gene and risk for AD, analyzing two common polymorphisms of the gene and the relationship between them and plasma cholesterol level control samples. Results: These polymorphisms showed no association with risk for AD. In rs5882, there was no significant difference in the mean plasma cholesterol concentrations found between patients with the A/A, A/G and G/G genotype. For rs2303790, no significant difference in the mean baseline cholesterol concentrations was found between patients with the A/A genotype and carriers of the G allele. Conclusion: Our study indicates that these polymorphisms, rs5882 and rs2303790 were not associated with risk for AD. We also pointed out that these two polymorphisms do not affect plasma cholesterol levels in our Japanese AD samples. 相似文献
64.
Nobuyoshi MUTO Harumichi SHIBATA Yasubumi SHIINA Hiroyuki TAKAYASU Minoru KONAGAYA Jun AOKI Sohtaro SUZUKI Takeshi MIWA 《Digestive endoscopy》1989,1(1):56-63
Abstract : A 52 year-old female was admitted to our hospital for lung cancer. We performed upper gastrointestinal endoscopy for her complaint of epigastralgia, and diagnosed Borrmann 2 type gastric cancer on the posterior wall of the angle. Chemotherapy with CDDP and VDS was commenced for lung cancer, and endoscopic Nd- YAG laser local hyperthermia (Laserthermia) was carried out for gastric cancer. Nd- YAG laser provided computer-controlled thermo-monitering system was irradiated in 3W, intermittently. Laserthermia could be applied safely to the clinical endoscopy. Conclusions were as follows; 1) Borrmann 2 type gastric cancer complicated with lung cancer was treated with laserthermia without severe complication. 2) This is the first report that the Laserthermia controlled by computer thermo-system was put in to clinical use. 3) Laserthermia with chemotherapy was more effective than laserthermia alone. 相似文献
65.
T. HAYAKAWA T. KONDO T. SHIBATA M. KITAGAWA S. NARUSE 《Journal of gastroenterology and hepatology》1992,7(5):527-532
Homologous and heterologous (human) pure pancreatic juice was infused into dogs to compare the behaviour of pancreatic enzymes in the circulation. This was achieved by estimating the magnitude of elevation and speed of disappearance of pancreatic enzymes in plasma. The half-lives of the plasma enzymes did not differ significantly between dogs and humans. However the half-lives of other enzymes (longest for amylase and shortest for trypsinogen) did differ. The magnitude of elevation expressed as a ratio of peak (5 min) to basal level was greatest for trypsinogen (28 times) and least for amylase (1.4 times). However, 289% and 410% of the initial lipase enzyme activity was recovered 5 min after infusion of dog and human pure pancreatic juice, respectively (44% when measured by immunoreactive human lipase activity). The excess recovery requires re-evaluation of diagnostic value of turbidimetric activity of plasma pancreatic lipase. 相似文献
66.
Hiroyuki MAGUCHI Takeshi OBARA Kiyoshi OKAMURA Satoshi ARISATO Akinori ITOH Yusuke SAITOH Mitsuhiro SOHMA Shigeru KITAMORI Yoshimi SHIBATA Masayoshi NAMIKI Yutaka ORII Hiromasa MINEMOTO 《Digestive endoscopy》1991,3(3):308-319
Abstract: We have developed a new method called the “Selective Endoscopic Retrograde Pancreatograpy (Selective ERP)” which uses a Radifocus guidewire to obtain a more precise pancreatogram than a standard ERP. The deep cannulation of a catheter guided by a Radifocus guidewire following standard ERP was easily and rapidly accomplished and precise pancreatograms were successfully obtained. The Selective ERP was very useful not only for obtaining detailed pancreatograms beyond severe stenosis of the main pancreatic duct in ductal cell carcinoma of the pancreas but also in revealing whether mucinous cystadenoma/cystadenocarcinoma communicated with the pancreatic duct or not. In the case of a mucin producing pancreatic tumor, Selective ERP successfully enabled us to obtain a whole pancreatogram and the location and extent of a tumor that standard ERP often fails to reveal because of an abundant accumulation of mucin in the duct. A Selective ERP is a simple and useful method for diagnosing pancreatic tumors and can provide precise and whole pancreatograms. We recommend Selective ERP as it enables us to obtain more complete diagnostic pancreatograms following standard ERP. 相似文献
67.
BACKGROUND: It has been shown that acute hypoxia induces the transient elevation of blood hemoglobin concentration ([Hb]) as a consequence of sympathetic-mediated splenic contraction to maintain the supply of oxygen, and splenectomy abolishes this phenomenon. The purpose of the present paper was to determine, retrospectively, whether the ability of transient elevation of [Hb] against acute hypoxia would be impaired in neonates with asplenia. METHOD: Eleven neonates who underwent surgery from 1998 to 2003 were enrolled in this retrospective study. They were divided into two groups: (i) five patients with asplenia syndrome with cyanotic congenital heart disease (asplenia group); and (ii) six patients with hypoplastic left heart syndrome who needed nitrogen gas inhalation therapy (HLHS group). In the asplenia group simultaneous data of arterial oxygen saturation (Sao(2)) and [Hb] were obtained before and after the temporary unexpected decrease of percutaneous arterial oxygen saturation. In the HLHS group they were obtained before and after nitrogen gas administration therapy. The arterial oxygen content (Cao(2)) changes and the ratio of Cao(2) change (Cao(2) after hypoxia divided by Cao(2) before hypoxia) were also calculated. RESULTS: In the asplenia group [Hb] was unchanged (12.9 +/- 1.6 g/dL to 12.8 +/- 1.4, n.s.) and Cao(2) was decreased (14.5 +/- 1.6 mL/dL to 11.9 +/- 1.1, P = 0.018). In the HLHS group [Hb] was increased (14.6 +/- 1.3 g/dL to 15.4 +/- 1.5, P = 0.028), but Cao(2) was changed (18.2 +/- 2.2 mL/dL to 16.7 +/- 3.0, P = 0.043). The ratio of Cao(2) change for the HLHS group was significantly different from that of the asplenia group (0.92 +/- 0.10, 0.83 +/- 0.10, respectively, P = 0.02). CONCLUSIONS: Patients with asplenia syndrome have some disadvantage regarding this protective mechanism against acute hypoxia. 相似文献
68.
TOSHIAKI FURUKAWA MD PhD HIROSHI TAKEUCHI MD TOSHIYUKI HIRAI MD SHIGEKI FUJIHARA MD PhD TOSHINORI KITAMURA MD PhD KIYOHISA TAKAHASHI MD PhD 《Psychiatry and clinical neurosciences》1998,52(6):577-579
Abstract Ancestral longevity is sometimes thought to contribute to psychosocial well-being in late life. The resent paper aims to examine if parental longevity is associated with mental health among the elderly. The age at death of the parents was compared between 68 patients with major depression who were aged 65 or over and 40 subjects of the same age range without any history of psychiatric disorder. Cox regression revealed that the fathers of the elderly men with unipolar depression died at a significantly younger age than those of the control group. Several hypotheses are advanced to explain this unexpected and intriguing association. 相似文献
69.
TOSHIYUKI AOKI TAMIO HORIKO TAKAMICHI AKIMOTO 《Clinical and experimental dermatology》1982,7(4):377-386
An 11–year-old girl presented with generalized weal formation of 8 months' duration which occurred when she was cooled at rest or after physical effort. The ice cube test was only slightly positive. Injection of the patient's serum into her arm skin and into the skin of two volunteers produced immediate weals. This passive transfer reaction occurred most strongly at skin temperatures around 30 °C but not at 40 °C. The weal producing substance was provisionally identified as an unusual immunoglobulin M(IgM) by gel filtration, immunoadsorption and physicochemical treatments. 相似文献
70.
SUMIO NAKAJIMA M.D. SATOSHI NAKANO M.D. †YUJI HORIGUCHI M.D. ‡TOSHIYUKI SUZUKI M.D. 《The American journal of gastroenterology》1976,65(2):142-147
One hundred and thirty-nine patients were examined for possible chronic pancreatitis by means of both pancreozymin-secretin test and endoscopic pancreatography of pancreatocholangiography. Pancreatic function as assessed by the pancreozymin-secretin test was impaired in 89 (64%) of the entire group. No significant relationship was demonstrated between pancreatic secretion of fluid, bicarbonate and amylase and the diameter of main pancreatic duct in both the entire group of the subgroup of patients with pancreatic dysfunction. On pancreatogram no gross morphological abnormalities were found in a high proportion of patients whose pancreatic function was impaired in minimal to moderate degree. There was a significant linear correlation between the diameters of the main pancreatic duct and common bile duct. These data question the value of endoscopic pancreatography in the diagnosis of low to moderate grade chronic pancreatitis. 相似文献