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排序方式: 共有183条查询结果,搜索用时 15 毫秒
71.
72.
Gated cardiac magnetic resonance structural imaging: optimization by electronic axial rotation 总被引:1,自引:0,他引:1
Feiglin DH; George CR; MacIntyre WJ; O'Donnell JK; Go RT; Pavlicek W; Meaney TF 《Radiology》1985,154(1):129-132
Most magnetic resonance imaging has used body orthogonal axes with the Z axis placed along the length of the body and the X and Y axes at right angles to the body. This orientation is not optimum for the heart; visualization of sections along the short and long cardiac axes would best define cardiac structural detail and functional status. The new orientation was accomplished by selection of electronic angulation of the magnetic fields for each subject rather than by attempting to approximate the cardiac axes by altering the position of the patient. This technique improved visualization of comparative wall segments, valvular structures, and the true four-chamber view of the heart, and also gave the best visualization of the pericardium. In addition, more accurate estimates of chamber size and myocardial mass can be made from the short-axis orientation, since the sections are orthogonal to the myocardium. 相似文献
73.
74.
75.
Three dimensional imaging of the myocardium with radionuclides 总被引:1,自引:0,他引:1
76.
Syntenic organization of the mouse distal chromosome 7 imprinting cluster and the Beckwith-Wiedemann syndrome region in chromosome 11p15.5 总被引:8,自引:2,他引:8
Paulsen M; Davies KR; Bowden LM; Villar AJ; Franck O; Fuermann M; Dean WL; Moore TF; Rodrigues N; Davies KE; Hu RJ; Feinberg AP; Maher ER; Reik W; Walter J 《Human molecular genetics》1998,7(7):1149-1159
In human and mouse, most imprinted genes are arranged in chromosomal
clusters. Their linked organization suggests co-ordinated mechanisms
controlling imprinting and gene expression. The identification of local and
regional elements responsible for the epigenetic control of imprinted gene
expression will be important in understanding the molecular basis of
diseases associated with imprinting such as Beckwith- Wiedemann syndrome.
We have established a complete contig of clones along the murine imprinting
cluster on distal chromosome 7 syntenic with the human imprinting region at
11p15.5 associated with Beckwith- Wiedemann syndrome. The cluster comprises
approximately 1 Mb of DNA, contains at least eight imprinted genes and is
demarcated by the two maternally expressed genes Tssc3 (Ipl) and H19 which
are directly flanked by the non-imprinted genes Nap1l4 (Nap2) and Rpl23l
(L23mrp), respectively. We also localized Kcnq1 (Kvlqt1) and Cd81 (Tapa-1)
between Cdkn1c (p57(Kip2)) and Mash2. The mouse Kcnq1 gene is maternally
expressed in most fetal but biallelically transcribed in most neonatal
tissues, suggesting relaxation of imprinting during development. Our
findings indicate conserved control mechanisms between mouse and human, but
also reveal some structural and functional differences. Our study opens the
way for a systematic analysis of the cluster by genetic manipulation in the
mouse which will lead to animal models of Beckwith-Wiedemann syndrome and
childhood tumours.
相似文献
77.
Hepatitis B virus (HBV) infection may lead to acute or chronic hepatitis, cirrhosis and hepatocellular carcinoma. The incidence rate of paediatric hepatitis B is 0.2/100,000 to 1.8/100,000 in Canada. Hepatitis B virus infection is acquired largely through mother-to-infant (vertical) or community-based (horizontal) transmission in early childhood, whereas older children are susceptible to HBV infection through exposure to contaminated blood during intravenous drug use or through sexual transmission. Immigrants from endemic areas and some Native Canadian populations are also at a higher risk for HBV infection. Infection with HBV may manifest in three forms: acute self-limited hepatitis, chronic hepatitis or massive hepatic necrosis causing acute liver failure. The identification of HBV infection and the characterization of the disease relies on serological and virological tests. The course of chronic hepatitis B may be classified into three phases: an immunotolerant phase, an active phase and an inactive phase. Current treatment options include interferon-alpha and lamivudine for individuals with elevated serum alanine aminotransferase levels and markers of persistent viral replication. Children with chronic hepatitis B require regular monitoring and age-appropriate lifestyle counselling. Paediatricians are well-positioned to promote vaccination and encourage testing of those who are at risk for hepatitis B. With effective universal vaccination against hepatitis B, this infection could be essentially eliminated in Canada. 相似文献
78.
DAVID STANLEY NursD MSc BA Ng Dip HE RN RM TF AMANDA SHERRATT RGN RM RNP MNNP BHSc PG Dip – ANP Dip Ed PGCert 《Journal of nursing management》2010,18(2):115-121
stanley d. & sherratt a. (2010) Journal of Nursing Management 18, 115–121
Lamp light on leadership: clinical leadership and Florence Nightingale Aims The purpose of the present study was to use the example of Florence Nightingales’ nursing experience to highlight the differences between nursing leadership and clinical leadership with a focus on Miss Nightingales’ clinical leadership attributes. Background 2010 marks the centenary of the death of Florence Nightingale. As this significant date approaches this paper reflects on her contribution to nursing in relation to more recent insights into clinical leadership. Evaluation Literature has been used to explore issues related to nursing leadership, clinical leadership and the life and characteristics of Florence Nightingale. Key issues There are a few parts of Florence’s character which fit the profile of a clinical leader. However, Miss Nightingale was not a clinical leader she was a powerful and successful role model for the academic, political and managerial domains of nursing. Conclusion There are other ways to lead and other types of leaders and leadership that nursing and the health service needs to foster, discover and recognize. Implications for nursing management Clinical leaders should be celebrated and recognized in their own right. Both clinical leaders and nursing leaders are important and need to work collaboratively to enhance patient care and to positively enhance the profession of nursing. 相似文献
Lamp light on leadership: clinical leadership and Florence Nightingale Aims The purpose of the present study was to use the example of Florence Nightingales’ nursing experience to highlight the differences between nursing leadership and clinical leadership with a focus on Miss Nightingales’ clinical leadership attributes. Background 2010 marks the centenary of the death of Florence Nightingale. As this significant date approaches this paper reflects on her contribution to nursing in relation to more recent insights into clinical leadership. Evaluation Literature has been used to explore issues related to nursing leadership, clinical leadership and the life and characteristics of Florence Nightingale. Key issues There are a few parts of Florence’s character which fit the profile of a clinical leader. However, Miss Nightingale was not a clinical leader she was a powerful and successful role model for the academic, political and managerial domains of nursing. Conclusion There are other ways to lead and other types of leaders and leadership that nursing and the health service needs to foster, discover and recognize. Implications for nursing management Clinical leaders should be celebrated and recognized in their own right. Both clinical leaders and nursing leaders are important and need to work collaboratively to enhance patient care and to positively enhance the profession of nursing. 相似文献
79.
Chunqing Lin Joseph TF Lau King-Man Ho Man-Chun Lau Hi-Yi Tsui Kuen-Kong Lo 《BMC infectious diseases》2010,10(1):272
Background
The objective of this study is to estimate the incidence of genital warts in Hong Kong and explore a way to establish a surveillance system for genital warts among the Hong Kong general population. 相似文献80.