微小染色体维持蛋白与肿瘤的研究进展

微小染色体维持(MCM)蛋白家族是一类从太古代生物到高等真核生物广泛存在的高度保守的蛋白质。MCM蛋白与其他相关因子相互影响,共同在DNA复制、延长、转录及修复过程中发挥作用。MCM蛋白在细胞周期中异常高表达意味着细胞非典型增生甚至肿瘤的发生,提示MCM蛋白可作为增殖细胞的特殊标志物,在肿瘤的诊断、预后评价、临床治疗等方面具有广泛的应用前景。     

多媒体技术在医学影像教学实践中的应用

医学影像学是一门实践性很强的形象思维学科,如何合理应用多媒体技术手段开展现代医学影像学教学,本文就多媒体技术与传统板书教学的有机结合进行了有益的探讨。强调做好现代多媒体技术手段教学与传统教学的重要性是医学影像学教学一个值得重视和思考的问题。     

Quantifying the relationship of HIV infection with clinicopathological spectrum and outcome among patients with colorectal cancer in a South African population

IntroductionLiterature is limited on HIV and colorectal cancer (CRC) in sub-Saharan Africa despite it being the epicentre of the HIV epidemic,PurposeTo compare clinicopathological features and outcome of CRC in HIV-negative and HIV-positive patients.MethodsRetrospective analysis of a prospective CRC database. Demographic details, HIV status, anatomical site, disease stage, treatment and follow-up were documented.ResultsOf 715 patients with CRC, 145 and 570 tested positive and negative respectively for HIV. Median age was 45 (IQR 36–53 and 57 (IQR 45–66) years among HIV-positive and HIV-negative patients respectively (p<0.0001). Tumour differentiation differed between the two groups (p=0.003) but staging was not different (p=0.6). Surgical resection rate was 52% for HIV-positive patients versus 59% for HIV-negative patients (p=0.07). Median follow-up was 9 (IQR 2–20.5) months for HIV-positive patients and 12 (IQR 6–29) months for HIV-negative patients (p=0.154). Recurrence rate was 14.7% among HIV positive patients and 6.8% in HIV negative patients (p=0.089).ConclusionWhen compared with HIV-negative patients, HIV-positive patients with CRC presented at a younger age and tended to have lower surgical resection rates. There was no difference between the two groups with CRC in terms of anatomical sub-site distribution, disease staging and recurrence rates.