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The endothelial progenitor cell (EPC) capture stent is an innovative device that makes use of the ability of bone marrow-derived EPCs to migrate to injured arterial segments to facilitate healing. The EPC antibody surface, consisting of a covalently coupled polysaccharide intermediate coating with anti-human CD34 antibodies, is attached to a stainless steel stent. Upon stent placement, the anti-human CD34 antibodies will attract circulating EPCs, which are expected to develop into mature functional endothelium. This accelerated healing strategy aims to lower the risk of restenosis and stent thrombosis, as well as obviate prolonged dual antiplatelet therapy. Since the first-in-man study in 2003, a number of small-to-medium size registry and postmarketing studies that confirmed the good safety profile of the EPC capture stent have been published. However, due to lack of large-scale randomized trials, its effectiveness, compared with bare metal stents and drug-eluting stents, cannot be ascertained. Based on restudy angiographic data, instent late loss was approximately 0.7-0.9 mm, which compares unfavorably with that of drug-eluting stents. In order to improve the effectiveness of the EPC capture stent in reducing restenosis-while maintaining its pro-healing property-a bioengineered sirolimus-eluting stent known as the Combo stent was recently designed to combine the EPC capture technology with the abluminal elution of sirolimus. Data from animal studies have been encouraging. The first-in-man study of the Combo stent has been completed and results were presented. (J Interven Cardiol 2012;25:493-500). 相似文献
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Nelson Leung Morie Gertz Robert A. Kyle Fernando C. Fervenza Maria V. Irazabal Alfonso Eirin Shaji Kumar Stephen S. Cha S. Vincent Rajkumar Martha Q. Lacy Steve R. Zeldenrust Francis K. Buadi Suzanne R. Hayman Samih H. Nasr Sanjeev Sethi Marina Ramirez-Alvarado Thomas E. Witzig Sandra M. Herrmann Angela Dispenzieri 《Clinical journal of the American Society of Nephrology》2012,7(12):1964-1968
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Devalina Goswami Sweta Singh Ongkila Bhutia Dalim Baidya Chhavi Sawhney 《The Indian journal of surgery》2016,78(6):482-489
Temporomandibular joint ankylosis is a unique disease where fracture of the mandibular condyle or any other cause leading to ankylosis of the joint can lead to multiple problems if not detected and treated early. If affected in early years of life, it may cause facial dysmorphism, restricted mouth opening, and difficulty in eating, speech, and sleep. Early surgery and physiotherapy can restore the joint function to a great extent. Anesthetizing a pediatric patient with this disorder is a definite challenge which needs expertise in difficult airway management. 相似文献
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Monica Sethi Karan Patel Jonathan Zagzag Manish Parikh John Saunders Aku Ude-Welcome Eduardo Somoza Bradley Schwack Marina Kurian George Fielding Christine Ren-Fielding 《Journal of gastrointestinal surgery》2016,20(2):244-252