全文获取类型
收费全文 | 2850篇 |
免费 | 214篇 |
国内免费 | 8篇 |
专业分类
耳鼻咽喉 | 27篇 |
儿科学 | 116篇 |
妇产科学 | 81篇 |
基础医学 | 397篇 |
口腔科学 | 203篇 |
临床医学 | 273篇 |
内科学 | 582篇 |
皮肤病学 | 40篇 |
神经病学 | 104篇 |
特种医学 | 452篇 |
外科学 | 250篇 |
综合类 | 97篇 |
一般理论 | 1篇 |
预防医学 | 135篇 |
眼科学 | 9篇 |
药学 | 141篇 |
1篇 | |
中国医学 | 1篇 |
肿瘤学 | 162篇 |
出版年
2022年 | 15篇 |
2021年 | 33篇 |
2020年 | 30篇 |
2019年 | 35篇 |
2018年 | 38篇 |
2017年 | 38篇 |
2016年 | 28篇 |
2015年 | 39篇 |
2014年 | 69篇 |
2013年 | 91篇 |
2012年 | 108篇 |
2011年 | 123篇 |
2010年 | 93篇 |
2009年 | 95篇 |
2008年 | 104篇 |
2007年 | 108篇 |
2006年 | 115篇 |
2005年 | 95篇 |
2004年 | 105篇 |
2003年 | 81篇 |
2002年 | 55篇 |
2001年 | 57篇 |
2000年 | 50篇 |
1999年 | 53篇 |
1998年 | 90篇 |
1997年 | 95篇 |
1996年 | 90篇 |
1995年 | 73篇 |
1994年 | 50篇 |
1993年 | 68篇 |
1992年 | 45篇 |
1991年 | 40篇 |
1990年 | 46篇 |
1989年 | 88篇 |
1988年 | 61篇 |
1987年 | 68篇 |
1986年 | 63篇 |
1985年 | 90篇 |
1984年 | 49篇 |
1983年 | 49篇 |
1982年 | 36篇 |
1981年 | 42篇 |
1980年 | 46篇 |
1979年 | 14篇 |
1978年 | 20篇 |
1977年 | 32篇 |
1976年 | 25篇 |
1975年 | 25篇 |
1973年 | 8篇 |
1972年 | 12篇 |
排序方式: 共有3072条查询结果,搜索用时 15 毫秒
101.
Brian Cox James Duffy Victor Zdorichenko Corentin Bellanger Jessica Hurcum Benoît Laleu Kevin I. Booker-Milburn Luke D. Elliott Michael Robertson-Ralph Christopher J. Swain Stephen J. Bishop Irene Hallyburton Mark Anderson 《ACS medicinal chemistry letters》2020,11(12):2497
We utilized synthetic photochemistry to generate novel sp3-rich scaffolds and report the design, synthesis, and biological testing of a diverse series of amides based on the 1-(amino-methyl)-2-benzyl-2-aza-bicyclo[2.1.1]hexane scaffold. Preliminary antimalarial screening of the library provided promising compounds with activity in the 1–5 μM range with an enhanced hit rate. Further evaluation (solubility, drug metabolism and pharmacokinetics (DMPK), and toxicity) of a selected compound (9) suggested that this series represents an excellent opportunity for further optimization with the framework offering multiple opportunities for the addition of uniquely vectorally positioned extra functionality. 相似文献
102.
NA Hanchard DR Murdock PL Magoulas M Bainbridge D Muzny YQ Wu M Wang AL McGuire JR Lupski RA Gibbs CW Brown 《Clinical genetics》2013,83(5):457-461
The advent of whole‐exome next‐generation sequencing (WES) has been pivotal for the molecular characterization of Mendelian disease; however, the clinical applicability of WES has remained relatively unexplored. We describe our exploration of WES as a diagnostic tool in a 3½‐year old female patient with a 2‐year history of episodic muscle weakness and paroxysmal dystonia who presented following a previous extensive but unrevealing diagnostic work‐up. WES was performed on the proband and her two parents. Parental exome data was used to filter potential de novo genomic events in the proband and suspected variants were confirmed using di‐deoxy sequencing. WES revealed a de novo non‐synonymous mutation in exon 21 of the calcium channel gene CACNA1S that has been previously reported in a single patient as a rare cause of atypical hypokalemic periodic paralysis. This was unexpected, as the proband's original differential diagnosis had included hypokalemic periodic paralysis, but clinical and laboratory features were equivocal, and standard clinical molecular testing for hypokalemic periodic paralysis and related disorders was negative. This report highlights the potential diagnostic utility of WES in clinical practice, with implications for the approach to similar diagnostic dilemmas in the future. 相似文献
103.
104.
An alternative extrinsic pathway of human blood coagulation 总被引:7,自引:0,他引:7
To study the interrelationships of the major human coagulation pathways, factor X activation in normal and various deficient human plasmas was evaluated when clotting was triggered by dilute rabbit or human thromboplastin. Various dilutions of thromboplastin were added to plasma samples containing 3H-labeled factor X, and the time course of factor X activation was determined. At a 1/250 dilution of rabbit brain thromboplastin the rate of factor X activation in factor VIII or factor IX deficient plasma was only 10% of the activation rate seen for normal or factor XI deficient plasma. Reconstitution of the deficient plasmas with factors VIII or IX, respectively, restored normal factor X activation. Similar results were obtained when various dilutions of human thromboplastin replaced the rabbit thromboplastin. From these experiments, it is inferred that normal activation of factor X in plasma due to dilute thromboplastin requires factors VII, IX and VIII. An alternative extrinsic pathway that involves factors VII, IX, and VIII may be a major physiologic extrinsic pathway, and this pathway may help to explain the clinical observations of bleeding diatheses in patients deficient in factors IX or VIII. 相似文献
105.
Judith L. Swain Kenneth G. Morris Frederick P. Bruno Frederick R. Cobb 《The American journal of cardiology》1980,46(6):976-982
This study compared the noninvasive assessment of left ventricular function with radionuclide angiography with that obtained with ultrasonic sonomicrometry. Left ventricular ejection fraction and rate of ventricular ejection (dV/dt) were measured with both techniques over a wide range of ventricular function. Six dogs were prepared with epicardlal crystals across the major and minor axes of the left ventricle, paired transmural wall thickness crystals and a left ventricular catheter. The animals were studied while awake after they had recovered from operation. Left ventricular volume was calculated from the ultrasonic sonomicrometric dimension measurements and the equation for a prolate ellipsoid; dV/dt was calculated from the stroke volume and ejection time. Radionuclide angiograms were performed using technetium-99m-labeled red blood cells and an Anger camera with a converging collimator interfaced to a computer programmed for multigated acquisition.A wide range of ventricular function was produced with sequential infusion of isoproterenol, propranolol, phenylepnrine and sodium thiamylal. Ejection fraction and dV/dt were measured simultaneously during each intervention using the time-activity curves of the multigated radionuclide anglogram and ultrasonic sonomicrometric dimensions. Regression analyses demonstrated a close correlation between the simultaneous measurements of ejection fraction (r values ranged from 0.95 to 0.99) and dV/dt (r values ranged from 0.87 to 0.99). these data indicate that noninvasive multigated radionuclide angiography accurately assesses changes in ejection fraction and dV/dt over a wide range of ventricular function. 相似文献
106.
Reddy PK Dharmapuram AK Swain SK Ramdoss N Raghavan SS Murthy KS 《Asian cardiovascular & thoracic annals》2008,16(2):129-133
Valve repair in children is technically demanding but more desirable than valve replacement. From April 2004 to September 2005, 1 boy and 8 girls with rheumatic heart disease, aged 2-13 years (median, 9 years), underwent valve repair for isolated mitral regurgitation in 5, combined mitral and aortic regurgitation in 2, mitral stenosis in 1, and mitral regurgitation associated with atrial septal defect in 1. Chordal shortening in 7, annular plication in 6, commissurotomy in 1, reconstruction of commissural leaflets in 7 were performed for mitral valve disease. Plication and reattachment of the aortic cusps was carried out in 2 patients. Annuloplasty rings were not used. All patients survived the operation, 8 had trivial or mild residual mitral regurgitation, and 1 had trivial aortic regurgitation. Mean left atrial pressure decreased from 14 to 7 mm Hg postoperatively. During follow-up of 3-18 months, all children were asymptomatic and enjoyed normal activity. None required reoperation. In addition to chordal shortening and annular plication, reconstruction of the commissural leaflets is considered the most important aspect of valve repair. It can be achieved without annuloplasty rings, giving good early and midterm results. 相似文献
107.
RD Vaithilingam SH Safii NA Baharuddin LP Karen‐Ng R Saub F Ariffin H Ramli A Sharifuddin MFH Hidayat R Raman YK Chan NA Rani RA Rahim N Shahruddin SC Cheong PM Bartold RB Zain 《Oral diseases》2015,21(1):e62-e69
Periodontal bio‐repositories, which allow banking of clinically validated human data and biological samples, provide an opportunity to derive biomarkers for periodontal diagnosis, prognosis and therapeutic activities which are expected to improve patient management. This article presents the establishing of the Malaysian Periodontal Database and Biobank System (MPDBS) which was initiated in 2011 with the aim to facilitate periodontal research. Partnerships were established with collaborating centres. Policies on specimen access, authorship and acknowledgement policies were agreed upon by all participating centres before the initiation of the periodontal biobank. Ethical approval for the collection of samples and data were obtained from institutional ethics review boards. A broad‐based approach for informed consent was used, which covered areas related to quality of life impacts, genetics and molecular aspects of periodontal disease. Sample collection and processing was performed using a standardized protocol. Biobanking resources such as equipment and freezers were shared with the Malaysian Oral Cancer Database and Tissue Bank System (MOCDTBS). In the development of the MPDBS, challenges that were previously faced by the MOCDTBS were considered. Future challenges in terms of ethical and legal issues will be faced when international collaborations necessitate the transportation of specimens across borders. 相似文献
108.
109.
110.
Dhariwal R Ray JG Pattanayak SM Swain N 《Journal of the Indian Society of Pedodontics and Preventive Dentistry》2012,30(1):85-88
Oral submucous fibrosis is a chronic debilitating disorder which is usually seen in adults with areca nut chewing habit. A rapid upsurge in the popularity of commercial areca nut products, especially among the younger generation, is a cause of grave concern, as satisfactory management is still lacking. Hereby, two pediatric cases of oral submucous fibrosis are reported. 相似文献