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991.
Bergström I Parini P Gustafsson SA Andersson G Brinck J 《Journal of bone and mineral metabolism》2012,30(2):202-207
The purpose of this study was to explore whether mechanical loading by exercise over a 1–year period in postmenopausal women
had an effect on the receptor activator for nuclear factor kappa B ligand/osteoprotegerin (RANKL/OPG) system or the levels
of the Wnt-signaling antagonist sclerostin. A total of 112 postmenopausal were randomized to either sedentary life (controls)
or physical activity (training group). Ninety-two women fulfilled the study protocol. The training program consisted of three
fast 30-min walks and one or two 1-h aerobic training sessions per week. The effect on the bone mineral density of the hip
assessed with dual X-ray absorptiometry was positive as reported earlier. Blood samples were taken from participants at baseline
and after 1 year and serum levels of OPG, RANKL and sclerostin were quantified together with the bone metabolism markers C-terminal
telopeptide of collagen type I (CTX) and bone-specific alkaline phosphatase (BALP). The results were analyzed using an analysis
of covariance model using baseline values as the covariate. The training group displayed a clear mean increase of OPG +7.55 pg/ml
compared to controls (p = 0.007). The mean changes for RANKL +0.19 pg/ml (square-root transformed data) and sclerostin +0.62 pmol/l were non-significant
(p = 0.13 and p = 0.34). The changes in bone turnover markers CTX and BALP showed a tendency to decrease in the training group versus controls
but the changes were small and non-significant. Although our study is limited in number of participating women, we have been
able to show an OPG-associated, and RANKL- and sclerostin-independent, training-induced inhibition of postmenopausal bone
loss. 相似文献
992.
993.
David Montani Marie-Camille Chaumais Christophe Guignabert Sven Günther Barbara Girerd Xavier Jaïs Vincent Algalarrondo Laura C. Price Laurent Savale Olivier Sitbon Gérald Simonneau Marc Humbert 《Pharmacology & therapeutics》2014
Pulmonary arterial hypertension (PAH) is a rare disorder characterized by progressive obliteration of small pulmonary arteries that leads to elevated pulmonary arterial pressure and right heart failure. During the last decades, an improved understanding of the pathophysiology of the disease has resulted in the development of effective therapies targeting endothelial dysfunction (epoprostenol and derivatives, endothelin receptor antagonists and phosphodiesterase type 5 inhibitors). These drugs allow clinical, functional and hemodynamic improvement. Even though, no cure exists for PAH and prognosis remains poor. Recently, several additional pathways have been suggested to be involved in the pathogenesis of PAH, and may represent innovative therapies. In this summary, we review conventional therapy, pharmacological agents currently available for the treatment of PAH and the benefit/risk ratio of potential future therapies. 相似文献
994.
Jim Werngren Maria Wijkander Nasrin Perskvist V. Balasubramanian Vasan K. Sambandamurthy Camilla Rodrigues Sven Hoffner 《Antimicrobial agents and chemotherapy》2014,58(7):4222-4223
The MIC of the novel antituberculosis (anti-TB) drug AZD5847 was determined against 146 clinical isolates from diverse geographical regions, including eastern Europe, North America, Africa, and Asia, using the automated Bactec Mycobacterial Growth Indicator Tube (MGIT) 960 system. These isolates originated from specimen sources such as sputum, bronchial alveolar lavage fluid, pleural fluid, abscess material, lung biopsies, and feces. The overall MIC90 was 1.0 mg/liter (range, 0.125 to 4 mg/liter). The MICs of AZD5847 for isolates of Mycobacterium tuberculosis were similar among drug-sensitive strains, multidrug-resistant (MDR) strains, and extensively drug resistant (XDR) strains. The good in vitro activity of AZD5847 against M. tuberculosis and the lack of cross-resistance make this agent a promising anti-TB drug candidate. 相似文献
995.
George Zhang Wei Katherine A. Martin Peter Yuli Xing Ruchi Agrawal Luke Whiley Thomas K. Wood Sophia Hejndorf Yong Zhi Ng Jeremy Zhi Yan Low Janet Rossant Robert Nechanitzky Elaine Holmes Jeremy K. Nicholson Eng-King Tan Paul M. Matthews Sven Pettersson 《Proceedings of the National Academy of Sciences of the United States of America》2021,118(27)
996.
Stephan Goetze Pascal Defaye Alexander Bauer Matthias Merkel Olivier Bizeau Sven Treusch Klaus Contzen Claus Juenger Joachim Winter 《Journal of interventional cardiac electrophysiology》2013,38(1):1-9
Purpose
Despite novel left ventricular (LV) lead technologies, phrenic nerve stimulation (PNS) remains an adverse effect observed in many patients with cardiac resynchronization therapy (CRT). Beyond anatomic repositioning, modern CRT devices allow avoidance of PNS also by software-based adaption of the pacing configuration. The Electronic Repositioning With Acuity and Easytrak Leads study evaluated the incidence of PNS in a CRT population and examined how often LV lead relocation can be avoided by “electronic repositioning” (ER).Methods
Patients who had an indication for implantation of a first CRT defibrillator with the option of ER were enrolled. Primary endpoint was the efficiency of ER determined by the frequency of PNS with the standard pacing configuration (LV tip to RV coil) avoidable by ER. PNS and pacing parameters were evaluated during implant, predischarge, and first routine follow-up (FU) using four different pacing configurations available by ER.Results
In total, 292 patients were enrolled and provided with a transvenous LV lead (82.2 % male, 65.5?±?9.2 years old). The majority of the population was in NYHA III (84.2 %) with a LV ejection fraction of 25.3?±?6.8 % and mean QRS width of 155?±?27 ms, ischemic cardiomyopathy was present in 43.6 %. Median FU was 116 days. In the standard pacing configuration, PNS was inducible in 19.0/25.6/24.6 % at implant/predischarge/FU, respectively, resulting in 32.2 % of the patients presenting at least once with PNS. The safety margin for the standard pacing configuration between LV and PNS threshold was <1.0 V at 0.5 ms in 5.6/7.0/5.0 % of the patients, corresponding with a total rate of 11.6 % during the FU. In the finally chosen configuration, clinically relevant PNS occurred in 1.0/2.2/1.3 %. The four vector configurations allowed all but 6 of 292 (2 %) patients to be reprogrammed using ER without reoperation.Conclusions
The incidence of inducible PNS in CRT patients is considerable. In this study, PNS could be avoided in the majority of the patients by means of electronic repositioning. Thus, the use of ER should be considered for CRT patients. 相似文献997.
998.
999.
1000.
Matej Orešič Tuulia Hyötyläinen Anna Kotronen Peddinti Gopalacharyulu Heli Nygren Johanna Arola Sandra Castillo Ismo Mattila Antti Hakkarainen Ronald J. H. Borra Miikka-Juhani Honka An Verrijken Sven Francque Patricia Iozzo Marja Leivonen Nabil Jaser Anne Juuti Thorkild I. A. Sørensen Pirjo Nuutila Luc Van Gaal Hannele Yki-Järvinen 《Diabetologia》2013,56(10):2266-2274