Basal Cell Carcinoma-Signet Ring Type

Light microscopic examination of a basalioma (basal cell carcinoma) revealed unusual keratinizing cells resembling signet ring cells with pink cytoplasmic inclusions. Ultrastructurally the inclusions consisted of filamentous masses encircled by abundant tonofilaments giving a striking picture of abnormal individual tumor cell keratinization.     

EFFECT OF POLICOSANOL SUCCESSIVE DOSE INCREASES ON PLATELET AGGREGATION IN HEALTHY VOLUNTEERS

Policosanol is a cholesterol-lowering drug with hypocholesterolemic effects demonstrated in experimental models, healthy volunteers and type II hypercholesterolemic patients. In addition, antiplatelet effects of policosanol have been shown in experimental models and healthy volunteers. The effect of successively increasing doses of policosanol on platelet aggregation was investigated in a randomized, placebo-controlled, double-blind study conducted in 37 healthy volunteers. The volunteers were on a placebo-baseline period (two tablets per day) for 7 days and thereafter they received randomly, under double-blind conditions, placebo or policosanol (10mgday⁻¹) for 7 days. After this period dosage was doubled to 20mgday⁻¹for the next 7 days and then again doubled to 40mgday⁻¹, while the control group received placebo tablets all the time. Platelet aggregation as well as coagulation time was measured at baseline and after each dosing step. Results showed that antiplatelet effects of policosanol were successfully enhanced throughout the study, thus suggesting a dose-dependent relationship. No significant effect was reached during the first dosing period, but significant reductions of epinephrine and ADP-induced platelet aggregation were observed after the second one. Finally, a significant inhibition of platelet aggregation induced by all the agonists was observed at the last dosing step. Coagulation time remained unchanged during the trial.     

停通气缺氧预处理减轻窒息致心停跳大鼠脑缺血损伤

目的 观察停通气缺氧预处理对窒息致心停跳大鼠脑缺血损伤的影响.方法 成年雄性Wistar大鼠被随机分为:心停跳(ACA)组,大鼠遭受4min窒息心停跳后复苏;预处理加心停跳(HP ACA)组,先给予大鼠1min的停通气缺氧预处理4次,每次间隔5min.24h后给予4min窒息心停跳并复苏;对照(C)组,不进行预处理和心停跳.观察各组大鼠心肺复苏后24h死亡率;心跳停止所需窒息时间(TCA);恢复自主循环所需时间(TROSC);测定心肺复苏后24h脑含水量;心肺复苏后24、48、72h神经功能评分(NDS),包括神智清醒程度,颅神经功能,感觉运动功能以及简单的行为测试等,完全正常为100分,死亡为0分.结果 对照组大鼠全部存活,预处理组大鼠死亡率为5%,心停跳组大鼠死亡率为30%;与心停跳组相比,预处理组TCA明显延长,差异有统计学意义(P＜0.01),而TROSC则明显缩短,差异有统计学意义(P＜0.01);心停跳组与预处理组相比脑水含量也明显增多,差异有统计学意义(P＜0.05);预处理组和心停跳组大鼠NDS显著低于对照组,差异有统计学意义(P＜0.01);心停跳组大鼠NDS较预处理组亦明显降低,差异有统计学意义(P＜0.05).结论 停通气缺氧预处理能明显减轻窒息致心停跳大鼠脑缺血损伤,并改善神经预后功能.     

细胞色素P450 1A1和2D6基因多态性与慢性苯中毒的危险性

目的 探讨细胞色素P450 1A1和2D6基因多态性与慢性苯中毒易感性的关系.方法 采用病例-对照研究,选择152名苯中毒工人为病例组,152名接触苯而无中毒表现的工人为对照组.采用限制性片段聚合酶链反应（PCR-RFLP）技术检测CYP1A1基因3＇端非编码区MspⅠ和CYP2D6第1外显子c.188位点、g.212位点多态性.结果 携带CYP1A1 MspⅠT/T基因型的个体发生苯中毒的危险性是携带有CYP1A1 Msp Ⅰ T/C或C/C基因型的个体的1.32倍（95%CI：1.05～1.65,P=0.02）;在不吸烟的人群中,携带CYP1A1 MspⅠ T/T基因型的个体发生苯中毒的风险性是携带T/C或C/C基因型的个体的1.56倍（95%CI：1.15～2.12,P=0.003）;携带有CYP2D6 c.188 C/C或C/T基因型个体发生苯中毒的危险性是携带有CYP2D6 c.188 T/T基因型的个体的1.23倍（95%CI：1.05～1.42,P=0.01）,在不吸烟的人群中,携带CYP2D6 c.188 C/C或C/T基因型个体发生苯中毒的危险性是携带有CYP2D6 c.188 T/T基因型的个体的1.23倍（95%CI：1.04～1.47,P=0.01）.未发现研究对象的CYP2D6g.212位点存在多态性.结论 携带CYP1A1 Msp ⅠT/T基因型、CYP2D6 c.188 C/C和C/T基因型个体对苯中毒可能易感.     

Recurrent Streptococcus pneumoniae meningitis in a child with traumatic anterior cranial base defect

Acute bacterial meningitis is a potentially life-threatening infection of the cranial and spinal leptomeninges. Recurrent episodes of meningitis are rarely seen, but when they occur, an extensive investigation has to be made to find out responsible factors. A single episode of acute meningitis may result from bacteriemia, but when followed by recurrent meningitis in pediatric patients, other possible routes of the bacteria invasion to the cerebrospinal fluid (CSF) should be considered. Patients with head injury have the highest risk of acquiring recurrent bacterial meningitis, followed by patients with a congenital anatomic lesion of the skull or duramater, such as meningomyelocele. The underlying cause is a transdural communication between the meningeal space and paranasal sinuses or skin. The first attack of meningitis may occur several weeks to 12 years after the head injury. In addition, recurrent bacterial meningitis may be due to disorders of the immune system, such as complement deficiency. We report a 14-year-old boy, who suffered from recurrent Streptococcus pneumoniae meningitis due to a well-defined defect at the ethmoid roof after a head trauma.     

Adenovirus-mediated Transfer of p53 and p16Inhibiting Proliferating Activity of Human Bladder Cancer Cell EJin vitro and in vivo

Previous studies have shown the tumor sup-pressor genes p5 3and p1 6were mutated or defect-ed in70 % and73% of the transurethral resectionbladder tumor( TURBt) specimens respectively[1] .The aim of this study was to evaluate the effects ofadenovirus ( Ad) - mediated transfer of p5 3and p1 6on the proliferating activity of human bladder can-cer cells EJboth in vitro and in vivo.1　 MATERIAL SAND METHODS1 .1　 Cell Lines and Adenoviral VectorsThe human bladder cancer cell line EJwas …     

下呼吸道感染菌的分布及耐药性分析

目的: 研究下呼吸道所感染病原菌的分布以及耐药状况,给临床治疗下呼吸道感染性疾病提供参考
依据,并且可以指导临床合理使用抗菌药物。方法: 对诊断为下呼吸道感染病人的深部痰液进行培养,共培养分
离出3936 株致病菌,对其鉴定及药物敏感试验的结果进行了回顾性分析。结果: 下呼吸道感染病原菌中鲍曼不
动杆菌检出率最高为905 株( 23%) ,其次为肺炎克雷伯菌818 株( 20．8%) 、铜绿假单胞菌768 株( 19．5%) 、金黄
色葡萄球菌405 株( 10．3%) 、大肠埃希菌350 株( 8．9%) ; 对亚胺培南的耐药率: 大肠埃希菌最低为0．1%,肺炎克
雷伯菌为0．3%。鲍曼不动杆菌和铜绿假单胞菌的耐药率较高,未发现耐万古霉素金黄色葡萄球菌。结论: 下呼
吸道感染主要病原菌为鲍曼不动杆菌和肺炎克雷伯菌,对头孢类和喹诺酮类药物的耐药率明显较高,临床应依
据药敏报告结果合理选用抗菌药物。     

2008年昆山市部分肺结核患者心理状况调查

[目的]探讨肺结核患者心理状况。[方法]使用Zung焦虑自评量表（SAS）、抑郁自评量表（SDS）对120例肺结核患者进行测评,并与120名健康者对照。[结果]肺结核患者两量表评分均显著高于健康者,SAS总分均值病例组为53．79,对照组为35．25,SDS总分均值病例组为51．42,对照组为34．08。[结论]肺结核患者有肯定的焦虑和抑郁,在治疗躯体疾病的同时,也要注重心理治疗。     

农药多菌灵对大青叶有效成分靛蓝、靛玉红含量的影响

目的:探讨农药多菌灵对大青叶有效成分靛蓝、靛玉红含量的影响。方法:通过田间试验设计3个试验组,在9个不同时间段内采集样品,采用高效液相色谱法测定大青叶中靛蓝、靛玉红的含量。结果:施用高、低浓度多菌灵后大青叶的有效成分均低于空白对照组。结论:施用一定浓度的多菌灵可降低大青叶中有效成分的含量。