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101.
102.
EFFECTS OF -GUANIDINE--METHYLQUINAZOLINE ON GASTRIC ACID SECRETION IN RATS 《Pharmacological research》1996,34(5-6)
In this study 2-guanidine-4-methylquinazoline (2-GMQ) appeared to decrease basal and stimulated gastric acid secretion, while structurally related compounds as dimethyl- biguanide, cyanoguanidine and 2-cyanoamino-4-methylpyrymidine did not. Thus, there is an antisecretory effect when the biguanide group is associated with a lipophilic structure. The antisecretive effects exerted by 2-GMQ are associated with anti H2-histamine activity.The anti H2-histamine nature of the effects of 2-GMQ was confirmed by the capacity of this compound of depressing the chronotropic activity of the isolated guinea pig auricle increased by histamine, as well as relaxant activity in rat uterus contracted by histamine, since both preparations are rich in H2-histamine receptors. 相似文献
103.
正常人腰椎间盘的MRI测量及其临床意义 总被引:2,自引:0,他引:2
目的:为国人开展腰椎间盘人工髓核假体(prostheticdicsnucleus,PDN)置换术提供影像解剖学资料。方法:对56例正常人的腰椎间盘(男44例,女12例)MRIT2加权像中髓核矢状径、横径,椎间隙前、中、后高度进行了测量。所选PDN假体为目前统一规格:前后径为12mm,高度分别为5mm、7mm、9mm。结果:髓核矢状径、横径及椎间隙高度均数之间无明显性别差异(P>0.05)。髓核矢状径均大于12mm,但大于24mm在L2/3中为23.2%,L3/4中21.4%,L4/5中21.4%,L5/S1中16.1%。椎间隙后高较低,5mm~9mm者在L2/3中为85.7%,L3/4中82.1%,L4/5中82.1%,L5/S1中58.9%,大于9mm者L2/3中0%,L3/4中1.8%,L4/5中1.8%,L5/S1中3.6%。结论:国人中大多数人腰椎间盘内仅可容纳单枚PDN假体,适合高度为5mm或7mm,可因人而异选择。 相似文献
104.
牙周炎患者基础治疗前后牙周袋内挥发性硫化物水平的变化 总被引:5,自引:1,他引:5
目的 :了解牙周炎患者治疗前后牙周袋内挥发性硫化物水平的变化。方法 :对 8例牙周炎患者的 5 1颗牙进行牙周基础治疗 ,并于治疗前及治疗后 4周用金刚牙科探针记录颊侧近远中牙周袋内共 10 2个位点的挥发性硫化物 (volatilesulfurcompounds,VSC )水平及菌斑指数 (plaqueindex ,PI)、牙周探诊深度 (probingdepth ,PD )、出血指数(bleedingindex ,BI )及临床附着水平 (clinicalattachmentlevel ,CAL )。结果 :牙周基础治疗后 4周 ,牙周袋内VSC水平及牙周各项临床指标均明显下降 (P <0 .0 0 1)。结论 :牙周袋内VSC可能是反映牙周组织状况的一项较为客观的指标。 相似文献
105.
目的探讨回肠代膀胱扩大术治疗氯胺酮导致膀胱挛缩患者围手术期的护理要点。方法选取行回肠代膀胱扩大术治疗的因服用氯胺酮导致膀胱挛缩的患者6例,从术前、术后、并发症的处理及出院指导4个方面总结该类患者的护理要点。结果患者均手术顺利,肝肾功能恢复正常,经过精心护理,患者均治愈出院,临床疗效满意。结论回肠代膀胱扩大术是治疗氯胺酮导致膀胱挛缩的有效手段,精心的护理是患者手术成功及术后恢复的必要手段。 相似文献
106.
目的了解浙江省嘉兴市15岁以上健康成人麻疹保护性抗体水平,为制定成人麻疹防控策略提供科学数据。方法采用分层随机抽样的方法,采集嘉兴市15~74岁之间的569名健康成人血清,采用间接酶联免疫法(ELISA)定量检测麻疹IgG抗体。结果嘉兴市15岁以上健康成人麻疹IgG抗体阳性率为94.38%,保护率为54.31%,麻疹IgG抗体GMC为999.24IU/L。其中20~岁年龄组保护率最低,为45.92%,50~岁年龄组保护率最高,为71.64%,各年龄组麻疹抗体保护率差异有统计学意义(χ^2=14.84,P=0.038),本地人口麻疹抗体保护率为50.94%,外地人口麻疹抗体保护率为57.24%,不同户籍与麻疹抗体保护率差异无统计学意义(χ^2=2.26,P=0.152)。结论嘉兴市15岁以上成人麻疹保护性抗体水平总体较低,建议做好初三学生麻风疫苗的常规接种,同时提高育龄妇女体内麻疹保护性抗体水平。 相似文献
107.
A. SHIRAHATA K. FUKUTAKE S. HIGASA J. MIMAYA T. OKA M. SHIMA J. TAKAMATSU M. TAKI M. TANEICHI A. YOSHIOKA STUDY GROUP ON FACTORS INVOLVED IN FORMATION OF INHIBITORS TO FACTOR VIII IX PREPARATIONS 《Haemophilia》2011,17(5):771-776
Summary. Studies conducted in European and North American countries have demonstrated that various factors including races affect the frequency of inhibitor formation in haemophilia patients. The present study was undertaken to analyse factors affecting the incidence of inhibitor formation in Japanese haemophilia A and B patients. Analytical data were retrospectively collected from haemophilia A and B patients born after 1988, the year when monoclonal antibody‐purified factor VIII products were first marketed in Japan. Various data were collected from 184 patients (153 cases of haemophilia A; 31 cases of haemophilia B). The sample size of haemophilia B cases was too small to reveal any significant differences between the inhibitor formation group and the inhibitor‐free group in any of background variables. For patients with haemophilia A, on the other hand, univariate analysis identified the severity of haemophilia and a positive family history of inhibitor development as risk factors for the formation of inhibitors. In analyses of the clotting factor products used, the incidence of inhibitor formation did not differ significantly between the group treated with plasma‐derived products (29.7%) and the group treated with recombinant products (25.0%). When background variables were compared, age was higher in the group treated with plasma‐derived products but none of the other background variables differed between the two groups. These results suggest that in Japanese haemophilia patients, the type of clotting factor preparations used for therapy has not influenced the incidence of inhibitor formation. 相似文献
108.
109.
110.
JINKWAN KIM SEUNGGWAN LEE KWANGHO IN JEHYEONG KIM SEHWA YOU KYUNGHO KANG JAEJEONG SIM SANGYEUB LEE DAEWUI YOON JUNGBOK LEE CHOL SHIN 《Journal of sleep research》2009,18(3):313-320
Obstructive sleep apnoea (OSA) is a common syndrome, which is associated with a number of medical problems that impact morbidity and mortality. Although the precise mechanisms that underlie these associations are not fully understood, previous studies have suggested that patients with OSA show elevations of several biomarkers that are associated with cardiovascular risk. This study was undertaken to identify serum proteins associated with OSA by using a proteomics technique and to examine changes in identified protein levels after continuous positive airway pressure treatment. The study participants consisted of 40 male patients (aged 40–49 years) with severe OSA and 34 male control subjects matched for age and body mass index. All subjects underwent polysomnography. Using a proteomics approach, we identified nine proteins that were differentially expressed in patients with severe OSA and controls. Three of these nine proteins, haptoglobin, paraoxonase-1 and apolipoprotein M, were quantified by using enzyme-linked immunosorbent assays, kinetic assays and by using Western blotting. Multiple regression analysis showed that haptoglobin and apolipoprotein M levels are independently related to apnoea–hypopnoea index ( P < 0.01). A further study is required to determine the nature of associations between these identified proteins and OSA in a large population. 相似文献