渔用麻醉剂使用现状和检测技术研究进展

对高效液相色谱串联质谱法（HPLC⁃MS/MS）测定水产品中5种卡因类（cacaines）麻醉剂及其代谢物残留量的不确定度进行评定。

建立不确定度评定的数学模型,分析影响测定结果的各不确定度来源,并对各分量加以量化和合成,探讨各不确定度分量对测定结果的影响。

分析评定不确定度各分量,结果表明不确定度贡献主要来自标准曲线拟合、样品溶液制备、样品加标回收率、标准溶液配制和测量的重复性。当河虾中3⁃氨基苯甲酸乙酯甲基磺酸盐（MS⁃222）含量为8.68 μg‧kg^-1时,其扩展不确定度为1.18 μg‧kg^-1（k=2）;苯佐卡因含量为9.11 μg‧kg^-1时,其扩展不确定度为1.28 μg‧kg^-1（k=2）;4⁃氨基苯甲酸含量为91.4 μg‧kg^-1时,其扩展不确定度为13.5 μg‧kg^-1（k=2）;对乙酰氨基苯甲酸含量为91.0 μg‧kg^-1时,其扩展不确定度为12.2 μg‧kg^-1（k=2）;间氨基苯甲酸含量为95.3 μg‧kg^-1时,其扩展不确定度为11.3 μg‧kg^-1（k=2）。

该方法适用于HPLC⁃MS/MS测定卡因类麻醉剂及其代谢残留量的不确定度分析,可为水产品中卡因类麻醉剂及其代谢测量结果的准确性提供科学可靠的依据。

     

两种鼓室硬化造模方法的比较

目的 应用鼓膜切开法和鼓室接种细菌法构建鼓室硬化动物模型,观察两种方法造模后其鼓膜和鼓室粘膜的组织形态学变化.方法 40只SD大鼠分为4组,每组10只:A1组双耳鼓膜不作处理,作为正常对照;A2组双耳鼓膜紧张部后下象限作2 mm的切口;B1组双侧鼓室不作处理,作为正常对照;B2组双侧鼓室接种1×108 CFU/ml肺炎链球菌0.1 ml.分别于鼓膜切开后第2周及鼓室接种肺炎链球菌后第1、2、4、6、8周时观察各组大鼠鼓膜情况,比较鼓室硬化发生率;分别于造模后第2周和第8周取材行听泡连续切片HE染色,观察鼓膜及鼓室粘膜的组织形态学变化.结果 A2组14耳发生鼓膜钙化(14/20,70%);B2组死亡一只,6耳发生鼓膜钙化(6/18,33.33%),两组的鼓膜及鼓室粘膜均可观察到炎症细胞浸润及纤维组织增生,但B2组的改变更显著.两对照组(A1和B1组)既未发生鼓膜钙化,也未出现组织形态学改变.结论 两种鼓室硬化造模方法均切实可行,但鼓膜切开法操作更简单,成模周期更短,成模率更高.     

Therapy-related acute myeloid leukemia in a primary pulmonary leiomyosarcoma patient with skin metastasis

Primary pulmonary leiomyosarcoma (LMS) is a very unusual tumor.Although LMS has well-known metastatic potential,cutaneous metastasis is a remarkably uncommon.Exposure to cytotoxic agents could lead to "therapy-related myeloid neoplasm" (t-MN).Starting from 2008,the World Health Organization (WHO) has adopted the term to cover the spectrum of malignant diseases previously known as therapy-related acute myeloid leukemia (t-AML),therapy-related myelodysplastic syndrome (t-MDS) and therapy-related myelodysplastic/myelo-proliferative neoplasm (t-MDS/MPN).We described the onset of t-MDS and progression to t-AML in one case diagnosed as primary pulmonary LMS with cutaneous metastasis.This patient achieved complete remission (CR) after three courses of IA regimen chemotherapy (idarubicin 5 mg/d,d 1-3;cytarabine 100 mg/d,d 1-5) and 1 course of HA chemotherapy regimen (homoharringtonine 3 mg/d,d 1-3;cytarabine 100 mg/d,d 1-7).This case presents the natural course of therapy-related neoplasm and provides therapeutic experience for t-AML.     

Ⅱ型糖尿病患者并发男性性功能障碍71例临床分析

Ⅱ型糖尿病引发男性性功能障碍患者经正规治疗,治疗组的性功能障碍改善显著优于对照组(P<0．05),说明积极控制血糖对糖尿病所并发的性功能障碍有较好疗效。     

从民国时期舌诊著作看中医舌诊学术的发展

以舌诊著作为切入点,探讨民国时期中医舌诊学术传承与发展。归纳出9大特点及创新:辑录诸家,博采众长;形式多样,内容丰富;图文并茂,绘图精致;设立学科,编写讲义;分门别类,提纲挈领;借助实验,研究舌诊;衷中参西,中西并用;参以己验,知常达变;阐幽发微,勇于创新。民国时期中医舌诊在困境中寻求发展,理论与实践均有显著创新,许多思想及观点至今仍有现实意义。     

玉液汤对2型糖尿病合并颈动脉粥样硬化的影响

目的:观察玉液汤对2型糖尿病合并颈动脉粥样硬化疗效及其对外周血T淋巴细胞和相关细胞因子影响性.方法:选取2017年4月至2019年4月德州市中医院收治的2型糖尿病合并颈动脉粥样硬化患者98例作为研究对象,按照随机数字表法分为对照组和观察组,每组49例.对照组常规西医降糖、降脂等治疗,观察组在对照组基础上加用汤剂玉液汤口...     

Prevalence and risk factors of hypertension among Hui population in China: A systematic review and meta-analysis based on 30,565 study participants

Background:Hypertension (HTN) has been considered as a health concern in developing countries. And Hui is a minority group with a large population in China. Its genetic background, inadequate access to health services, eating habits, religious belief, ethnic customs, and other factors differ from that of other ethnic groups, which may influence the prevalence of HTN. However, there is no current meta-analysis on the prevalence and risk factors of HTN among Hui population. Thus we conducted a systematic review aiming to estimate the pooled prevalence and risk factors of HTN among Hui population.Methods:PubMed, The Cochrane library, Web of science, CINAHL Complete, Weipu Database (VIP), China Knowledge Resource Integrated Database (CNKI), Wanfang Database, and SinoMed were systematically searched from inception to February 28, 2020 with publication language restricted to English and Chinese. We included cross-sectional, case–control, or cohort studies that focused on prevalence and risk factors of HTN among Hui population. Two investigators independently assessed the risk of bias of the studies included in the review using tools developed by JBI. Meta-analysis was conducted using Stata 12.0 software package.Results:Twenty-three studies were identified with a total of 30,565 study participants. The overall pooled prevalence of HTN was 28% (95% confidence interval [CI]: 24%–32%, I² = 98.8%, P < .001). Stratified by gender, the pooled prevalence of HTN in Hui was 26% (95%CI: 20%–33%, I² = 97.6%, P < .001) for males and 30% (95%CI: 23%–37%, I² = 98.3%, P < .001) for females. Pooled prevalence of HTN in Hui was 2% (95%CI: 2%–6%, I² = 70.6%, P = .065), 10% (95%CI: 3%–17%, I² = 83.7%, P < .001), 22% (95%CI: 12%–32%, I² = 87.9%, P < .001), 37% (95%CI: 20%–53%, I² = 94.0%, P < .001), 39% (95%CI: 24%–54%, I² = 97.7%, P < .001) and 42% (95%CI: 29%–56%, I² = 95.6%, P < .001) for those aged 18 to 29, 30 to 39, 40 to 49, 50 to 59, 60 to 69, and ≥70 years, respectively. Pooled prevalence of HTN in Hui was 22% (95%CI: 14%–29%, I² = 97.9%, P < .001) in urban areas and 23% (95%CI: 16%–30%, I² = 95.8%, P < .001) in rural areas. Daily salt intake (odd ratio [OR] = 3.94, 95%CI: 3.03–5.13, I² = 90.2%, P < 001), family history (OR = 3.50, 95%CI: 2.60–4.71, I² = 95.3%, P < .001), smoking (OR = 1.84, 95%CI: 1.61–2.09, I² = 59.6%, P < .001), drinking (OR = 1.74, 95%CI: 1.26–2.39, I² = 95.3%, P = .001), weekly meat intake (OR = 1.92, 95%CI: 1.04–3.54, I² = 96.5%, P = .036), body mass index (OR = 2.20, 95%CI: 1.81–2.66, I² = 91.3%, P < .001), and areas (OR = 1.29, 95%CI: 1.10–1.51, I² = 81.5%, P = .001) were risk factors of HTN in Hui, while physical exercise (OR = 0.76, 95%CI: 0.66–0.88, I² = 62.7%, P < .001) was protective factor.Conclusions:The pooled prevalence of HTN among Hui people was 28%, daily salt intake, family history, drinking, smoking, weekly meat intake, body mass index, areas, and physical exercise were all risk factors for HTN among Hui population. Early screening and treatment of HTN among Hui population should be given due attention.     

宫内节育器异常的超声检测

目的 评估B超诊断宫内节育器异常的价值。材料与方法 对781倒置节育器的育龄妇女作超声检查,观察了各种节育器异常与子宫位置、节育器类型、合并子宫肌瘤的关系。结果 中位子宫、金属单环、合并子宫肌瘤者节育器异常率较高、结论 B声是监测宫内节育器发挥避孕效果的一种有效方法。     

原发性输尿管癌的早期诊断与治疗(附26例报告)

目的：提高原发性输尿管癌的诊治水平。方法：回顾性分析26例原发性输尿管癌临床资料，比较各种检查方法，总结诊治经验。结果：26例术后均行病理检查证实为移性细胞癌。术前经B超、IVU、膀胱镜及逆行肾盂输尿管造影、CT、MRU等确诊24例(92．3％)。结论：联合应用B超、IVU、膀胱镜、逆行肾盂输尿管造影和CT、MRU检查方法，可提高原发性输尿管癌的诊断符合率。膀胱镜、逆行肾盂输尿管造影是原发性输尿管癌的最基本的检查手段。治疗以手术为主。     

基于CMR评价生脉散颗粒抑制慢性心力衰竭气阴两虚证患者心肌纤维化的临床疗效

目的：通过心脏核磁共振(CMR)成像及血清学指标评价生脉散颗粒对慢性心力衰竭气阴两虚证患者心肌纤维化的影响。方法：选择2021年10月至2023年1月于南京中医药大学附属中西医结合医院就诊的慢性心力衰竭气阴两虚证患者66例,采用最小化随机方法分为对照组和观察组各33例,两组均给予心力衰竭西医标准化治疗,对照组加予安慰剂颗粒治疗,观察组加予生脉散颗粒治疗,疗程6个月。比较两组患者基线资料、中医临床疗效、中医证候积分、炎症及纤维化指标[超敏C反应蛋白(hs-CRP)、可溶性生长刺激表达基因2蛋白(sST2)、Ⅲ型前胶原氨基末端肽(PⅢNP)、白细胞介素-6(IL-6)、白细胞介素-11(IL-11)、转化生长因子-β₁(TGF-β₁)]、超声心动图[左心房内径(LAD)、左室收缩末期内径(LVEDs)左室舒张末期内径(LVEDd)]、CMR指标[左心室射血分数(LVEF)、心肌细胞外容积分数(ECV)和纵向弛豫时间(T1值)]。结果：最终,对照组纳入31例患者,治疗组纳入30例患者。两组患者基线资料、治疗前观察指标差异无统计学意义。与本组治疗前比...