Microsurgical study of the interpeduncular cistern and its communication with adjoining cisterns

Objective  Investigating the structure, contents, location, and borders of interpeduncular cistern and its communications with adjoining cisterns. Materials and methods  Microsurgical anatomy of the interpeduncular cistern was studied in 14 adult cadaver brains, using a surgical microscope(×3 to ×40 magnification). Results  The interpeduncular cistern was divided into two portions: superficial (free) and deep (vascular). The superior wall of interpeduncular cistern was separated into the hypothalamic and mesencephalic part. It has communication with ambient, prepontine, carotid, cerebellopontine, oculomotor, and crural cisterns. Conclusion  The interpeduncular cistern is a compound bulk structure. This classification is necessary for the quantitative and qualitative study of the interpeduncular anatomy. Also, it is necessary to neurosurgeons for the guiding line in this region.     

3-甲基芬太尼衍生物的合成及镇痛活性

本文合成了6个1-取代-3-甲基芬太尼衍生物。初步的药理实验结果表明,它们均具有典型的吗啡样作用。某些1位β-取代乙烯基乙基衍生物有强镇痛活性。简要地讨论了其结构—活性关系。     

维生素B2和B6的同步荧光分析法及其在维生素复合制剂中的应用

本文建立了维生素B₂和B₆的同步荧光分析法。以△λ=58nm进行同步扫描所得的两个同步荧光峰(以发射波长表示,分别位于526nm和389nm)可用以同时分别定量维生素B₂和B₆。方法快速、灵敏。维生素B₂和B₆的工作曲线线性范围分别为0～1μg/ml和0～1.5μg/ml,检出限分别为0.5ng/ml和1ng/ml。方法已应用于三种复合维生素B制剂中维生素B₂和B₆的分析。     

国产檀香中α-反式香柠烯醇化学结构研究

从国产檀香木Santalum ablum L.分得一个新倍半萜醇,根据光谱(IR,MS,¹H-¹H COSY,¹³C-¹H COSY和¹H-¹H NOESY)解析,确定了它的化学结构和相对立体化学为9(10)-顺,α-反式香柠烯醇[9(10)Z,α-trans-bergamotenol](Ia)。     

Protective effect of adenosine receptor agonists in a model of spinal cord injury in rats

Possibilities of the neuroprotector therapy using adenosine and cyclopentyladenosine (CPA), an adenosine receptor agonist, were studied on a model of spinal cord injury by compression in rats (most closely reproducing the analogous clinical pathological process in humans). The model was induced by slow, graded compression of the spinal cord at the thoracic level. Adenosine and CPA were introduced 60 min before injury by subcutaneous injections in a dose of 300 and 2.5 micrograms/kg, respectively. The protective effect was judged by comparing the neurological, electromyographic, and histopathological changes in animals with the model injury and in the control group (adenosine and CPA background). The A1-agonist CPA injections produced a pronounced, statistically significant neuroprotector effect on the given spinal cord injury model in rats. The neuroprotective effect of adenosine was significant but not as strong. It is concluded that it is expedient to use A-agonists in clinics.