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排序方式: 共有274条查询结果,搜索用时 15 毫秒
61.
Sudakov SK Rusakova IV Trigub MN Shakhmatov VY Kozel AI Smith GE 《Bulletin of experimental biology and medicine》2004,138(5):479-481
We studied the effect of bilateral laser destruction of rat anterior cingulate gyrus on the analgesic effect of morphine and development of tolerance and physical dependence on morphine. Bilateral laser destruction of the anterior cingulate gyrus did not modulate pain sensitivity, analgesic effect of morphine, and development of morphine tolerance. Destruction of the cingulate gyrus alleviated symptoms of the abstinence syndrome in morphine-dependent animals. We showed that morphine-induced analgesia and morphine tolerance are not associated with activity of the anterior cingulate gyrus. However, this structure plays a key role in the development of physical dependence on morphine and abstinence syndrome.Translated from Byulleten Eksperimentalnoi Biologii i Meditsiny, Vol. 138, No. 11, pp. 540–543, November, 2004 相似文献
62.
Bogolepov NN Popova EN Koplik EV Krivitskaia GN Sudakov KV 《Morfologii?a (Saint Petersburg, Russia)》2003,123(2):15-20
In Wistar rats with different resistance to emotional stress (ES), subjected to stress exposure (SE), the structural organization of neurons in layer V of sensomotor cortex was studied quantitatively in brain sections stained using Nissl's cresyl violet method. One group of animals was injected with delta sleep-inducing peptide (DSIP) 1 hr before SE. In rats of control group predisposed to ES, the amount of normochromatic and moderately hypochromatic neurons was decreased as compared to the rats resistant to ES. After SE, normochromatic neurons were not demonstrated. In rats predisposed to ES, the contents of moderately hypo- and hyperchromatic neurons was found to fall dramatically with a simultaneous increase in the number of extremely hypo- and hyperchromatic neurons, ghost cells and ischemically changed cells. After DSIP infusion before SE, ischemically damaged cells were not found in any group, while the degree of shrinkage of extremely hyperchromatic neurons was lower in rats predisposed to ES as compared to rats resistant to ES. It is suggested that brain hypoxia plays an important role in cortex disorganization during ES, whereas DSIP, possesses both antistress and antihypoxic effects. 相似文献
63.
15 renal transplant recipients were studied for their lipid profile. The patients were on regular post transplant follow up and had non clinical or laboratory evidence of graft dysfunction, intercurrent infection or post transplant diabetes mellitus for at least 3 months prior to the study. The mean duration of transplant was 15 ± 9.5 months (range 3-32 months). Majority (86%) were on triple immunosuppression therapy and received a mean prednisolone dose of 10.5 mg. An equal number of healthy subjects were randomly selected and studied for their lipid profile and served as control for the study group. There was no significant change in the HDL-cholesterol level as compared with controls. However, these patients showed a significantly higher LDL-cholesterol and total cholesterol levels. Further, a significant inverse correlation was observed between triglycerides and total cholesterol levels and transplant duration.Key Words: Lipid profile, Renal transplant 相似文献
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K V Sudakov 《Physiology & behavior》1977,19(2):213-221
The role of experimental emotional stress in the genesis of arterial hypertension was studied. On immobilized rabbits during long-term electrical stimulation of the negative defence emotiogenic centers of the hypothalamus there was treaced development of the arterial hypertension from a transient phase of the struggle between pressor and depressor mechanisms to the phase of a stable dominance of pressor influences and effect on heart activity, including development of a sharp myocardial infarction. The role of different limbic and reticular structures, as well as of adrenal hormones and barocepor depressor mechanisms was revealed in dynamics of the arterial hypertension developmnet under hypothalamic stimulation. A leading role of the adrenergic substratum of the midbrain reticular formation was established in the mechanism of the stable arterial hypothalamic hypertension. 相似文献
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Sudakov KV 《Vestnik Rossi?sko? akademii meditsinskikh nauk / Rossi?skaia akademiia meditsinskikh nauk》2002,(6):8-13
The paper considers informational processes occurring within and between the body's functional systems. Informational demand-supply relations are constructed by the holographic principle. The apparatuses of outcome acceptors act as holographic informational screens in the functional systems. A concept of the non-specific informational syndrome of disintegration of different functional systems upon extreme exposures of human beings is formulated. Principles in non-drug rehabilitation of broken inter- and intrasystemic informational bonds are outlined. 相似文献
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