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961.
Fiona J Clay Stuart V Newstead Wendy L Watson Joan Ozanne-Smith Roderick J McClure 《BMC musculoskeletal disorders》2010,11(1):6
Background
To determine factors predicting the duration of time away from work following acute orthopaedic non life threatening trauma 相似文献962.
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965.
We report a case of acute bilateral central serous chorioretinopathy in a patient who received a local injection of triamcinolone for the treatment of plantar fasciitis. Central serous chorioretinopathy is a serious, though rare, ocular complication of steroid treatment and it may occur even when the steroid is administered at a site as remote from the eye as the foot. This case report highlights the need for greater awareness of this complication amongst all medical personnel who prescribe steroids. It is advisable that patients, undergoing steroid treatment for any cause, be alerted to the risk of sudden visual impairment. 相似文献
966.
Daniel R. Toms Leander Cannick Robert K. Stuart Joseph M. Jenrette Lacy Terwiliger 《Japanese journal of radiology》2010,28(6):476-478
Extramedullary hematopoiesis (EMH) refers to the development of foci of hematopoiesis outside its normal location in the bone
marrow. This occurs normally during fetal development but is abnormal postpartum. The most common sites of EMH are the spleen
and liver. The phenomenon occurs in a number of disease states, notably in myelofibrosis, thalassemia, immune thrombocytopenic
purpura, sickle cell anemia, polycythemia vera, and myelodysplastic syndrome. Affected patients often develop symptoms related
to the location of the EMH. Reported treatments include red blood cell transfusions, surgical excision, decompressive laminectomy
in cases of cord compression, chemotherapy, and irradiation. Radiation therapy is highly effective for treating hematopoietic
tissue because such tissues are extremely radiosensitive. Megavoltage helical tomotherapy is a technical advance in the delivery
of radiation therapy, allowing more conformal and precise treatments. The present case report describes a patient with the
diagnosis of atypical chronic myeloid leukemia and myelofibrosis who subsequently developed EMH of the pericardium with effusion
and tamponade. By utilizing tomotherapy we were able to treat the pericardium while sparing much of the myocardium. The patient
tolerated treatment well without acute adverse effects. His symptoms were alleviated, but he died approximately 1 year later. 相似文献
967.
968.
The mechanisms by which stress contributes to CTH are not clearly understood. The commonly accepted notion of muscle hyper-reactivity to stress in CTH sufferers is not supported in the research data. We propose a neural model whereby stress acts supra-spinally to aggravate already increased pain sensitivity in CTH sufferers. Indirect support for the model comes from emerging research elucidating complex supra-spinal networks through which psychological stress may contribute to and even cause pain. Similarly, emerging research demonstrates supra-spinal pain processing abnormalities in CTH sufferers. While research with CTH sufferers offering direct support for the model is lacking at present, initial work by our group is consistent with the models predictions, particularly, that stress aggravates already increased pain sensitivity in CTH sufferers. 相似文献
969.
Stuart Marcovitch Janet Leigh Susan D. Calkins Esther M. Leerks Marion O'Brien A. Nayena Blankson 《Developmental psychobiology》2010,52(6):603-608
Vagal tone (measured via respiratory sinus arrhythmia, RSA) and vagal withdrawal (measured by decreases in RSA) have been identified as physiological measures of self‐regulation, but little is known how they may relate to the regulation of cognitive activity as measured through executive function (EF) tasks. We expected that baseline measures of vagal tone, thought to be an indicator of attention, would correlate with EF performance. We also predicted that vagal withdrawal would allow for the reorientation of attention that is needed to succeed on EF tasks, but too much withdrawal would be detrimental. RSA measured at baseline was indeed related to EF performance in 220 3.5‐year‐old children, and those who exhibited a moderate decrease in RSA during the EF tasks outperformed children whose RSA decreased by too little or too much. These findings implicate vagal tone withdrawal as a psychophysiological measure of higher cognitive processes, most likely substantiated through increases in the levels of focused attention. © 2010 Wiley Periodicals, Inc. Dev Psychobiol 52: 603–608, 2010. 相似文献
970.
Stuart J. Knechtle Jean Kwun Neal Iwakoshi 《The Journal of clinical investigation》2010,120(4):1036-1039
Belying the spectacular success of solid organ transplantation and improvements in immunosuppressive therapy is the reality that long-term graft survival rates remain relatively unchanged, in large part due to chronic and insidious alloantibody-mediated graft injury. Half of heart transplant recipients develop chronic rejection within 10 years — a daunting statistic, particularly for young patients expecting to achieve longevity by enduring the rigors of a transplant. The current immunosuppressive pharmacopeia is relatively ineffective in preventing late alloantibody-associated chronic rejection. In this issue of the JCI, Kelishadi et al. report that preemptive deletion of B cells prior to heart transplantation in cynomolgus monkeys, in addition to conventional posttransplant immunosuppressive therapy with cyclosporine, markedly attenuated not only acute graft rejection but also alloantibody elaboration and chronic graft rejection. The success of this preemptive strike implies a central role for B cells in graft rejection, and this approach may help to delay or prevent chronic rejection after solid organ transplantation. 相似文献