全文获取类型
收费全文 | 22845篇 |
免费 | 2071篇 |
国内免费 | 66篇 |
专业分类
耳鼻咽喉 | 246篇 |
儿科学 | 742篇 |
妇产科学 | 518篇 |
基础医学 | 3128篇 |
口腔科学 | 377篇 |
临床医学 | 2546篇 |
内科学 | 4776篇 |
皮肤病学 | 221篇 |
神经病学 | 1920篇 |
特种医学 | 945篇 |
外科学 | 3631篇 |
综合类 | 394篇 |
一般理论 | 25篇 |
预防医学 | 2111篇 |
眼科学 | 492篇 |
药学 | 1553篇 |
1篇 | |
中国医学 | 20篇 |
肿瘤学 | 1336篇 |
出版年
2022年 | 135篇 |
2021年 | 401篇 |
2020年 | 265篇 |
2019年 | 408篇 |
2018年 | 518篇 |
2017年 | 364篇 |
2016年 | 387篇 |
2015年 | 451篇 |
2014年 | 658篇 |
2013年 | 875篇 |
2012年 | 1456篇 |
2011年 | 1459篇 |
2010年 | 809篇 |
2009年 | 702篇 |
2008年 | 1276篇 |
2007年 | 1338篇 |
2006年 | 1355篇 |
2005年 | 1318篇 |
2004年 | 1270篇 |
2003年 | 1184篇 |
2002年 | 1154篇 |
2001年 | 453篇 |
2000年 | 445篇 |
1999年 | 394篇 |
1998年 | 269篇 |
1997年 | 260篇 |
1996年 | 228篇 |
1995年 | 186篇 |
1994年 | 180篇 |
1993年 | 198篇 |
1992年 | 285篇 |
1991年 | 282篇 |
1990年 | 252篇 |
1989年 | 248篇 |
1988年 | 233篇 |
1987年 | 216篇 |
1986年 | 219篇 |
1985年 | 197篇 |
1984年 | 173篇 |
1983年 | 181篇 |
1982年 | 139篇 |
1981年 | 160篇 |
1980年 | 127篇 |
1979年 | 183篇 |
1978年 | 152篇 |
1977年 | 116篇 |
1975年 | 117篇 |
1974年 | 116篇 |
1973年 | 135篇 |
1972年 | 117篇 |
排序方式: 共有10000条查询结果,搜索用时 203 毫秒
101.
102.
103.
Lorraine N Clark Eneli Haamer Helen Mejia-Santana Juliette Harris Suzanne Lesage Alexandra Durr Sabine Janin Bs Katja Hedrich Elan D Louis Lucien J Cote Howard Andrews Stanley Fahn Cheryl Waters Blair Ford Steven Frucht William Scott Christine Klein Alexis Brice Hanno Roomere Ruth Ottman Karen Marder 《Movement disorders》2007,22(7):932-937
Parkin mutations account for the majority of familial and sporadic early onset Parkinson's disease (EOPD) cases with a known genetic association. More than 100 mutations have been described in the Parkin gene that includes homozygous, compound heterozygous, and single heterozygous mutations. We have designed a Parkin mutation genotyping array (gene chip) that includes published Parkin sequence variants and allows their simultaneous detection. The chip was validated by screening 85 PD cases and 47 controls previously tested for Parkin mutations. Similar genotyping microarrays have been developed for other genetically heterogeneous diseases including age-related macular degeneration. Here, we show the utility of a genotyping array for Parkinson's disease by analysis of 60 subjects from the Genetic Epidemiology of Parkinson Disease (GEPD) study that includes 15 early-onset PD case probands and 45 relatives. 相似文献
104.
105.
Marc D Moncrieff Stuart A Hamilton George H Lamberty Charles M Malata David G Hardy Robert Macfarlane David A Moffat 《Journal of plastic, reconstructive & aesthetic surgery》2007,60(6):607-614
Squamous cell carcinoma (SCC) of the temporal bone is a rare, aggressive and highly malignant tumour that requires specialised, multidisciplinary surgery for its treatment. Reconstruction of the defect is as crucial as the tumour ablation in terms of mortality and postoperative morbidity. METHODS: The experience of the East Anglian Skull Base Surgery Service from 1982 to 2004 in managing 42 consecutive patients (22 females; age range 37-80 years) undergoing extended and lateral temporal bone resection for SCC is presented. RESULTS: The overall 5-year survival was 31.0% (median follow up: 97 months) when both curative and palliative procedures were included. On multivariate analysis, the favourable prognostic factors were male sex, well-differentiated tumours and stage N(0) neck. The reconstructions in 38 patients were analysed. The majority (24/38) had free tissue transfer reconstructions and most of these were radial forearm free flaps. Later in the series, other free flap types such as anterolateral thigh flaps and lateral arm flaps were employed. Pedicled myocutaneous flaps and local flaps were also used. CONCLUSIONS: This paper analyses the outcomes of the various reconstructions and discusses the evolution of their care in our unit. The information obtained from the review of our data is extrapolated to offer guidance on the choice of reconstructive option in these patients. 相似文献
106.
Ralph Madeb Dragan Golijanin Joy Knopf Craig Nicholson Stuart Cramer Frederick Tonetti Kelly Piccone John R. Valvo Louis Eichel 《Journal of robotic surgery》2007,1(2):145-149
Several recent studies have suggested that thought leaders in radical prostatectomy have decreased their own positive margin
rates by switching from open to robot-assisted radical prostatectomy. Theoretically, this improvement is largely attributed
to enhanced visualization of the deep pelvis and precision of dissection afforded by the instrumentation. To date, it has
not been determined if this phenomenon exists amongst non-fellowship-trained urologists in private practice. Herein, we describe
the positive margin rates of two non-fellowship-trained private-practice urologists who converted from open radical retropubic
prostatectomy to robot-assisted radical prostatectomy. The margin positivity data from two non-fellowship-trained private-practice
urologists (surgeon 1 and surgeon 2) were reviewed retrospectively. The last 50 cases of open radical retropubic prostatectomy
from each surgeon were compared with the first 50 robotic prostatectomy cases of surgeons 1 and 2, respectively. A positive
surgical margin was defined as tumor present at the inked margin of the prostate. There was a significant decrease in the
overall and pT2 positive margin rates for both surgeons. The overall positive margin rate and pT2 positive margin rate for
surgeon 1 dropped from 44 to 20% and from 37 to 5.7%, respectively, after changing from open to robotic prostatectomy. For
surgeon 2, the overall positive margin rate changed from 26 to 18% and the pT2 positive margin rate changed from 27.5 to 7%
after converting. Changing from open to robotic-assisted radical prostatectomy may improve the ability of urologists to obtain
negative surgical margins. With proper training this phenomenon does seem to apply to non-fellowship-trained urologists in
private practice and can be realized within the first 50 cases performed. 相似文献
107.
108.
Mechanoregulation of human articular chondrocyte aggrecan and type II collagen expression by intermittent hydrostatic pressure in vitro. 总被引:6,自引:0,他引:6
109.
110.
Kenneth W. Locke Robert W. Dunn John W. Hubbard Cheri L. Vanselous Michael Cornfeldt Stuart Fielding Joseph T. Strupczewski 《Drug development research》1990,19(3):239-256
HP 818 (1-benzoyl-6-fluoro-3-(1-methyl-4-piperidinyl)-1H-indazole) exhibits the profile of a potent nonnarcotic analgesic with neuroleptic properties. HP 818 blocks the effects of chemical (phenylquinone), pressure (tail clip), and radiant heat (tail flick) painful stimuli in mice (ED50 values of 0.3, 1.2, and 4.1 mg/kg s.c., respectively). This compound displays antinociceptive activity by the subcutaneous, oral, and intravenous routes of administration. It is also effective in the shock titration assay in squirrel monkeys and in a model of surgically induced pain. The rank order of potency of HP 818 and several other standard compounds in these tests for analgesia was Innovar > fentanyl > HP 818 > codeine > droperidol. In addition to its antinociceptive effects, HP 818 possesses neuroleptic properties. It is active in the climbing mouse, pole climb avoidance, and intracranial self-stimulation assays (ED50 values of 1.8, 1.7, and 2.5 mg/kg i.p., respectively). Moreover, HP 818 inhibits amphetamine- and apomorphine-induced stereotypy, indicative of D2-dopaminergic blocking properties. HP 818, unlike typical neuroleptic agents, does not induce supersensitivity to the effects of apomorphine when administered chronically in mice. In contrast to the clinical standard neuroleptanalgesic Innovar, HP 818 (1.0–3.0 mg/kg i.v.) produces no significant cardiovascular or respiratory changes in the anesthetized dog. Thus, HP 818 is potentially an effective presurgical medication due to its nonnarcotic analgesic activity and sedative neuroleptic effects, along with its lack of limiting cardiorespiratory side effects. 相似文献