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101.
The metabolism of an essential amino acid, isoleucine, by human leukemic and gradient-separated normal human leukocytes of various types and maturity was studied. Blood leukocytes were isolated and incubated with (U-14C) isoleucine. Separation of metabolic intermediates was accomplished by sequential extraction. The rate of isoleucine incorporation into protein by immature cells from untreated patients with acute leukemia (15.9 plus or minus 2.4 nmoles/hr per 10-8 leukocytes) was considerably higher than the rates of incorporation by mature neutrophils (3.2 plus or minus 0.5 nmoles/hr per 10-8 leukocytes), lymphocytes (7.7 plus or minus 1.2 nmoles/hr per 10-8 leukocytes), and eosinophils (6.2 plus or minus 1.3 nmoles/hr per 10-8 leukocytes). Those cell preparations with more blast cells had higher rates of protein synthesis. In addition, those cells with greater thymidine incorporation had higher rates of protein synthesis. The leukocytes both oxidized isoleucine and incorporated it into cell isoleucine and incorporated it into cell lipid. The rates of these metabolic processes were characteristic for various types and maturity of leukocytes. This study demonstrates a relationship of rate of protein synthesis to leukocyte immaturity. This relationship is maintained in neoplastic leukocytes. It suggests that the requirement of the mitotic process for newly synthesized protein is greater than that for the elaboration of the protein products of the mature leukocyte. 相似文献
102.
Multiple sclerosis with clinical and radiological features of cerebral tumour 总被引:5,自引:2,他引:3 下载免费PDF全文
HJ Sagar CP Warlow PWE Sheldon MM Esiri 《Journal of neurology, neurosurgery, and psychiatry》1982,45(9):802-808
Three cases of multiple sclerosis, all confirmed pathologically, are described in whom both the unusual clinical features and the CT scan appearances suggested cerebral tumours. The failure of mass effect reliably to differentiate plaques and tumours on a CT scan is stressed and the literature relating to CT scanning in multiple sclerosis is reviewed. 相似文献
103.
Proctalgia Fugax in Patients with the Irritable Bowel, Peptic Ulcer, or Inflammatory Bowel Disease 总被引:2,自引:0,他引:2
W. Grant Thompson M.D. F.A.CP. F.A.CG. F.R.C.P. 《The American journal of gastroenterology》1984,79(6):450-452
One hundred forty-eight patients with gastrointestinal disease, 50 patients with the irritable bowel syndrome (IBS) and 49 each with peptic ulcer and inflammatory bowel disease, were interviewed to determine if they had proctalgia fugax (PF) and if the symptom was associated with the IBS. One-third of the patients had PF. It occurred in 51% of females and 12% of males (p less than 0.001). When corrected for sex, PF was no more prevalent in IBS than in peptic ulcer or inflammatory bowel disease. Only two of six previously described IBS symptoms were more prevalent in the PF patients. Attacks occurred in the day in 94%, and one-third of sufferers related them to defecation. The pain was localized in the anus in 90%, occurred less than five times a year in 51%, and lasted less than 1 min in 57%. In most, activity was not interrupted by this pain and only 20% had ever reported it to a physician. PF is very common among patients with abdominal symptoms, but is not related to the IBS. Since it is infrequent, benign, and transient, PF is usually not mentioned to the physician. 相似文献
104.
105.
106.
The onset of cardiac cachexia is characterized by a defined severe weight loss in patients with advanced chronic heart failure
and it predicts an increased mortality in these patients. Recent studies with potential therapeutics investigated the effects
and efficiency of beta-blockers, ghrelin, or ghrelin-agonists in cachexia. These and other new studies, like the influence
of heart transplantation on cardiac cachexia, give prospect into potential therapeutic options in the future. General aim
of the treatment strategy is to prevent the onset and retard the progress of cachexia. This could be achieved by modifying
the metabolic, neurohormonal and immune system abnormalities, e.g. with beta-blockers and angiotensin-converting enzyme inhibitors.
However, these alterations interact in a complex pathophysiological process, which is supposed to end in a vicious circle
and thereby the wasting process is further promoted. To interrupt this, an early start of therapy is important to decelerate
the development of cardiac cachexia. Many further investigations are needed to find out more about the pathophysiological
pathways, to confirm the previous results, and to evaluate new therapeutics. 相似文献
107.
Robert Hörster Detlef Kirsten Karoline Iris Gaede Claudia Jafari Alan Strassburg Ulf Greinert Barbara Kalsdorf Martin Ernst Christoph Lange 《The clinical respiratory journal》2009,3(4):229-238
Introduction: Sarcoidosis is a multisystem granulomatous disease of unknown origin. Pathogenetic involvement of Mycobacterium tuberculosis has frequently been discussed in the aetiology of sarcoidosis; however, studies still remain contradictory. Objective: We addressed the question of mycobacterial involvement in the pathogenesis of sarcoidosis by analysing cellular immune responses to mycobacterial antigens. Methods: We examined the interferon (IFN)‐γ production by enzyme‐linked immunospot in response to purified protein derivate (PPD) mycobacterial‐specific antigen early secretory antigenic target (ESAT)‐6 and culture filtrate protein (CFP)‐10 by peripheral blood mononuclear cells (PBMCs) and bronchoalveolar‐lavage mononuclear cells (BALMCs) of patients with pulmonary sarcoidosis, smear‐negative tuberculosis and controls. Results: Release of IFN‐γ in response to ex vivo contact with PPD, ESAT‐6 or CFP‐10 by BALMC and PBMC were comparable among patients with sarcoidosis and controls (PBMC P = 0.2326; BALMC P = 0.1767) and were less frequently observed in both groups compared to patients with tuberculosis (BALMC P < 0.05; PBMC P < 0.0001). Within PBMC, the immunophenotype of sarcoidosis patients differed from that of patients with tuberculosis, as well as from that of controls, while within BALMC it resembled that of patients with tuberculosis. Conclusion: In contrast to patients with tuberculosis, the frequency of mycobacteria‐specific local and systemic immune responses is not elevated in patients with sarcoidosis when compared to controls. The immunophenotype represents the local resemblance of the granulomatous reaction underlying tuberculosis and sarcoidosis while showing systemical difference. These observations do not support a role of an infection with M. tuberculosis in the pathogenesis of sarcoidosis. Please cite this paper as: Hörster R, Kirsten D, Gaede KI, Jafari C, Strassburg A, Greinert U, Kalsdorf B, Ernst M and Lange C. Antimycobacterial immune responses in patients with pulmonary sarcoidosis. The Clinical Respiratory Journal 2009; 3: 229–238. 相似文献
108.
PD Dr. O. Guckelberger U.P. Neumann P. Neuhaus M. Manns C.P. Strassburg 《Der Gastroenterologe》2009,4(5):419-426
The survival of patients with primary sclerosing cholangitis (PSC) is reduced in part because of an increased incidence of cholangiocellular carcinoma. However, the timing of liver transplantation represents a considerable clinical challenge. The clinical course of PSC is frequently slowly progressive and can develop acutely with the occurrence of septic cholangitis. In most cases this situation is not adequately reflected by established prognostic models, including the Model for End-Stage Liver Disease (MELD) score, which is the basis for donor organ allocation in liver transplantation candidates. Therefore, an exceptional-case status has been defined for certain transplantation candidates with PSC (?Exceptional MELD“). The increased risk of cholangiocarcinoma alone does not warrant prophylactic liver transplantation. The overall results after liver transplantation for PSC are generally better than for other indications, although up to 40% develop recurrent PSC or a PSC-like syndrome. In PSC patients with cholangiocarcinoma, liver transplantation should not be performed outside of clinical studies. The prevalence of chronic inflammatory bowel disease after liver transplantation in patients with PSC is reported to exceed 65% (up to 100%) and is usually classified as ulcerative colitis. Proctocolectomy can be safely performed after transplantation. However, the extent to which patients have an improved course of recurrent PSC after proctocolectomy has yet to be established. 相似文献
109.
We report on 4 boys from 3 families presenting initially in infancy with an acute onset of flaccid tetraparesis and areflexia, resembling Guillain-Barré syndrome (GBS). However, the cerebrospinal fluid (CSF) protein was normal, while serum and CSF lactate were elevated. All patients had recurrent similar episodes, usually associated with infections. Brain MRI showed T (2) hyperintensities in the basal ganglia in two boys, in one of them at the first clinical presentation; the other one had a normal brain MRI during the first episode. A third boy had a normal MRI twice but an increased lactate peak in the basal ganglia in (1)H-MR spectroscopy. Motor nerve conduction velocities (NCV) were normal in all patients. Biochemical analyses of muscle tissue, performed in two patients, revealed a deficiency of the pyruvate dehydrogenase (PDH). Molecular genetic analysis of the X-chromosomal E1alpha subunit of PDH showed three new mutations in phylogenetically conserved areas of the protein: Glu358Lys in patient 1; Arg88Lys in patient 2 and 3 (brothers); and Leu216Ser in patient 4. In conclusion, children with "atypical GBS" should be evaluated for a mitochondrial disorder, including pyruvate dehydrogenase deficiency, even after a first episode. 相似文献
110.
Christine A. Elnitsky PhD RN Gail A. Latlief DO Erin E. Andrews PsyD Laurel B. Adams‐Koss MOT OTR/L Samuel L. Phillips PhD CP 《Rehabilitation nursing》2013,38(1):32-36