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91.
J. P. Pfammatter J. W. Weber F. P. Stocker M. Gertsch H. Moser L. Kappenberger 《Clinical cardiology》1993,16(6):517-520
Two brothers, 10 and 9 years old, are reported who were treated for years with antiepileptic drugs until the cardiac origin of their syncopal attacks was discovered. Our findings are consistent with the diagnosis of long QT syndrome, although no other family members are affected and only intermittent and mostly borderline QT prolongation could be found. Diagnostic difficulties and genetic implications are discussed. 相似文献
92.
93.
94.
W. Ertel M. Keel D. Marty R. Hoop A. Safret R. Stocker O. Trentz 《Der Unfallchirurg》1998,101(7):520-526
Summary
The association between the increasing severity of systemic inflammatory response syndrome (SIRS) and the incidence of posttraumatic
complications and mortality was retrospectively investigated in 1278 injured patients. Patients were divided into three groups
according to their Injury Severity Score (ISS) (group A: ISS L 9 K16 points (n = 626); group B: ISS > 16 < 40 points (n = 589); group C: ISS L 40 points (n = 63)). SIRS was defined according to the criteria of the American Consensus Conference. The number of fulfilled criteria
determined its severity: moderate SIRS: 2 criteria fulfilled, intermediate SIRS: 3 criteria fulfilled, severe SIRS: 4 criteria
fulfilled. Additionally, acute respiratory distress syndrome (ARDS) was defined according to the Murray-Score and the multiple
organ dysfunction syndrome (MODS) according to the Goris-Score. The incidence of SIRS was 42 % in group A, 70 % in group B
and 100 % in group C (p < 0.05). The severity of SIRS increased with severity of trauma. Moreover, 178 of all injured patients (14 %) developed septic
complications. In parallel to SIRS, the incidence of these septic complications correlated with the severity of trauma. The
occurrence and severity of ARDS and MODS correlated with increased severity of SIRS and septic complications. Among patients
without SIRS 15 % developed ARDS and 21 % MODS. In contrast, patients with severe SIRS and septic complications demonstrated
ARDS in 99 % and MODS in 97 %. In these patients, no correlation was found between the ISS and the incidence of ARDS or MODS.
There were also stepwise increases in mortality rates in the hierarchy from SIRS to septic shock. While 13 of patients with
modest SIRS (5 %) and 32 of patients with intermediate SIRS (13 %) died, the mortality rate of patients with severe SIRS was
19 % (p < 0.05). In addition, a significant correlation between the incidence of septic complications and mortality was found. Injured
patients with sepsis died in 13 %, those with severe sepsis in 23 %, and patients with septic shock in 33 % (p < 0.05). Thus, the increasing severity of SIRS was associated with the occurrence of posttraumatic ARDS, MODS, and mortality.
Using the number of fulfilled SIRS criteria for classifying systemic inflammation, its severity may be predictive for posttraumatic
complications and outcome of injured patients.
相似文献
95.
96.
J. Thomas Stocker 《Fetal and pediatric pathology》1983,1(3):367-368
Hoidal JR, Niewoehner DF: Pathogenesis of emphysema. Chest 83:679-685, 1983. 相似文献
97.
98.
The isoelectric point of Protac was recently estimated to be at pH 3. However, further investigations using different experimental procedures revealed that Protac, due to its particular binding properties, is able to form complexes with carrier ampholytes. Thus, the actual isoelectric point of Protac was found to be in the basic region. 相似文献
99.
100.
Proteinase activities have been determined photometrically in 25 different Crotalidae and Viperidae snake venoms by using five different chromogenic proteinase substrates. The activity profiles obtained by listing the identity numbers of substrates hydrolyzed by the venoms in a decreasing potency order remained quite stable within a given snake population. Submission of a venom to various physical and chemical treatments did not alter its activity profile. It is therefore concluded that this simple method of determining proteinase activities could be of help in snake venom characterization, as well as in studying the influence of metallic ions and inhibitors of snake venom proteinases. 相似文献