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91.
Norbert Weiss Stefanie A. G. Black Chris Bladen Lina Chen Gerald W. Zamponi 《Pflügers Archiv : European journal of physiology》2013,465(8):1159-1170
Low-voltage-activated T-type calcium channels play important roles in neuronal physiology where they control cellular excitability and synaptic transmission. Alteration in T-type channel expression has been linked to various pathophysiological conditions such as pain arising from diabetic neuropathy. In the present study, we looked at the role of asparagine (N)-linked glycosylation on human Cav3.2 T-type channel expression and function. Manipulation of N-glycans on cells expressing a recombinant Cav3.2 channel revealed that N-linked glycosylation is critical for proper functional expression of the channel. Using site-directed mutagenesis to disrupt the canonical N-linked glycosylation sites of Cav3.2 channel, we show that glycosylation at asparagine N192 is critical for channel expression at the surface, whereas glycosylation at asparagine N1466 controls channel activity. Moreover, we demonstrate that N-linked glycosylation of Cav3.2 not only controls surface expression and activity of the channel but also underlies glucose-dependent potentiation of T-type Ca2+ current. Our data suggest that N-linked glycosylation of T-type channels may play an important role in aberrant upregulation of T-type channel activity in response to glucose elevations. 相似文献
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93.
Thomas Helbing Eva‐Maria Herold Alexandra Hornstein Stefanie Wintrich Jennifer Heinke Sebastian Grundmann Cam Patterson Christoph Bode Martin Moser 《The Journal of pathology》2013,231(1):105-116
Epithelial injury is a central finding in pulmonary disease and is accompanied by disruption of epithelial barrier function, leading to pulmonary oedema and inflammation. Injured epithelial cells lose their properties and gain mesenchymal characteristics, a phenotypic switch that contributes to lung remodelling after injury. Here we studied bone morphogenetic protein (BMP) signalling and, in particular, the role of BMP2 and the BMP modulator BMPER in injured lung epithelium. Increased BMP activity, reflected by up‐regulation of the Smad1/5–Id1 axis, is detected after injury of lung epithelium in vitro and in vivo. Two members of the BMP family, BMP2 and BMPER, have opposing effects. BMP2 is up‐regulated after epithelial injury and causes epithelial dysfunction and hyperpermeability, mediated by the Smad1/5–Id1‐dependent down‐regulation of E‐cadherin. In contrast, BMPER expression is decreased following injury, which in turn impairs epithelial integrity, characterized by reduction of E‐cadherin and epithelial leakage in vitro and in vivo. High levels of BMPER antagonized BMP2‐Smad5–Id1 signalling and prevented BMP2‐mediated decrease of E‐cadherin and hyperpermeability, suggesting that BMPER restores epithelial homeostasis. Supporting this notion, pharmacological inhibition of BMP signalling by LDN193189 prevented reduction of E‐cadherin and disruption of epithelial barrier function. Inhibition of excessive BMP activation could be a new approach to restore epithelial integrity and prevent disruption of epithelial barrier function after lung injury. Copyright © 2013 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. 相似文献
94.
Carla Palleis MD Julia Sauerbeck Leonie Beyer MD Stefanie Harris Julia Schmitt Estrella Morenas-Rodriguez PhD Anika Finze Alexander Nitschmann Francois Ruch-Rubinstein Florian Eckenweber Gloria Biechele Tanja Blume MSc Yuan Shi PhD Endy Weidinger MD Catharina Prix MD Kai Bötzel MD Adrian Danek MD Boris-Stephan Rauchmann MD Sophia Stöcklein MD Simon Lindner PhD Marcus Unterrainer MD Nathalie L. Albert MD Christian Wetzel PhD Rainer Rupprecht MD Axel Rominger MD Peter Bartenstein MD Jochen Herms MD Robert Perneczky MD Christian Haass PhD Johannes Levin MD Günter U. Höglinger MD Matthias Brendel MD 《Movement disorders》2021,36(4):883-894
95.
Stefanie J.G. Veenhuis MD Nienke J.H. van Os MD PhD Anjo J.W.M. Janssen PhD Marjo H.J.C. van Gerven MSc Karlien L.M. Coene PhD Udo. F.H. Engelke PhD Ron A. Wevers PhD Gerjen H. Tinnevelt PhD Rob ter Heine PhD Bart P.C. van de Warrenburg MD PhD Corry M.R. Weemaes MD PhD Nel Roeleveld PhD Michèl A.A.P. Willemsen MD PhD 《Movement disorders》2021,36(12):2951-2957
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97.
Koop Barbara Elisabeth Mayer Felix Gündüz Tanju Blum Jacqueline Becker Julia Schaffrath Judith Wagner Wolfgang Han Yang Boehme Petra Ritz-Timme Stefanie 《International journal of legal medicine》2021,135(1):167-173
International Journal of Legal Medicine - Age estimation based on the analysis of DNA methylation patterns has become a focus of forensic research within the past few years. However, there is... 相似文献
98.
Bohnert Simone Reinert Christoph Trella Stefanie Schmitz Werner Ondruschka Benjamin Bohnert Michael 《International journal of legal medicine》2021,135(1):183-191
International Journal of Legal Medicine - In the last few years, quantitative analysis of metabolites in body fluids using LC/MS has become an established method in laboratory medicine and... 相似文献
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100.
Rues Stefan Schmitter Marc Kappel Stefanie Sonntag Robert Kretzer Jan Philippe Nadorf Jan 《Clinical oral investigations》2021,25(3):1265-1272
Clinical Oral Investigations - Conventional dental implants inserted in the molar region of the maxilla will reach into the sinus maxillaris when alveolar ridge height is limited. When surgery is... 相似文献