全文获取类型
收费全文 | 50607篇 |
免费 | 2598篇 |
国内免费 | 178篇 |
专业分类
耳鼻咽喉 | 622篇 |
儿科学 | 1084篇 |
妇产科学 | 748篇 |
基础医学 | 7716篇 |
口腔科学 | 1351篇 |
临床医学 | 4385篇 |
内科学 | 10976篇 |
皮肤病学 | 1214篇 |
神经病学 | 5234篇 |
特种医学 | 2893篇 |
外国民族医学 | 23篇 |
外科学 | 7053篇 |
综合类 | 237篇 |
一般理论 | 20篇 |
预防医学 | 2364篇 |
眼科学 | 941篇 |
药学 | 3287篇 |
中国医学 | 69篇 |
肿瘤学 | 3166篇 |
出版年
2023年 | 345篇 |
2022年 | 493篇 |
2021年 | 930篇 |
2020年 | 604篇 |
2019年 | 845篇 |
2018年 | 1072篇 |
2017年 | 854篇 |
2016年 | 1214篇 |
2015年 | 1383篇 |
2014年 | 1617篇 |
2013年 | 2089篇 |
2012年 | 3337篇 |
2011年 | 3364篇 |
2010年 | 1985篇 |
2009年 | 1727篇 |
2008年 | 2962篇 |
2007年 | 3055篇 |
2006年 | 3001篇 |
2005年 | 2849篇 |
2004年 | 2525篇 |
2003年 | 2407篇 |
2002年 | 2288篇 |
2001年 | 1019篇 |
2000年 | 1050篇 |
1999年 | 972篇 |
1998年 | 502篇 |
1997年 | 367篇 |
1996年 | 289篇 |
1995年 | 247篇 |
1994年 | 216篇 |
1993年 | 172篇 |
1992年 | 395篇 |
1991年 | 415篇 |
1990年 | 389篇 |
1989年 | 366篇 |
1988年 | 297篇 |
1987年 | 299篇 |
1986年 | 259篇 |
1985年 | 264篇 |
1984年 | 207篇 |
1983年 | 150篇 |
1982年 | 151篇 |
1979年 | 199篇 |
1978年 | 149篇 |
1977年 | 139篇 |
1975年 | 171篇 |
1974年 | 151篇 |
1973年 | 164篇 |
1972年 | 154篇 |
1971年 | 137篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
Stefan Sobaniec Piotr Bernaczyk Jan Pietruski Magdalena Cholewa Anna Skurska Ewa Dolińska Ewa Duraj Grażyna Tokajuk Agnieszka Paniczko Ewa Olszewska Małgorzata Pietruska 《Lasers in medical science》2013,28(1):311-316
The study objective was clinical assessment of the efficacy of photodynamic therapy (PDT) in the treatment of oral lichen planus (OLP). There were 23 patients aged 31–82 included in the study with oral lichen planus diagnosed clinically and histopathologically. In all patients photodynamic therapy was performed with the use of chlorin e6 (Photolon®), containing 20 % chlorin e6 and 10 % dimethyl sulfoxide as a photosensitizer. PDT was performed using a semiconductor laser, with power up to 300 mW and a wavelength of 660 nm. A series of illumination sessions was conducted with the use of superficial light energy density of 90 J/cm2. Changes of lesion size were monitored at one, two, five, and ten PDT appointments from the series of ten according to the authors' own method. The sizes of clinical OLP lesions exposed to PDT were reduced significantly (on average by 55 %). The best effects were observed for the lesions on the lining mucosa (57.6 %). The therapy was statistically significantly less effective when masticatory mucosa was affected (reduction, 30.0 %). Due to substantial efficacy and noninvasiveness, PDT can be useful in the treatment of OLP lesions. 相似文献
992.
Roos M Schuster T Ndrepepa G Baumann M Lutz J Braun S Martinof S Schömig A Heemann U Kastrati A Hausleiter J 《Heart and vessels》2012,27(4):352-359
Midregional proadrenomedullin (MR-proADM) is elevated in patients with heart failure and myocardial infarction. The aim of this study was to evaluate the association of MR-proADM with the grade of coronary artery stenosis, presence of coronary artery soft plaques and coronary artery calcification score (CACS), determined by 64-multislice computed tomography (MSCT) in patients without known prior cardiovascular disease. This retrospective study included 107 patients undergoing MSCT for confirmation (or exclusion) of coronary artery disease. MR-proADM levels were measured in all patients. The assessment of coronary artery stenoses, CACS and soft coronary plaques was made by MSCT using known criteria. The MR-proADM [median (25th–75th percentiles)] level was 0.33 (0.21–0.43)?nmol/l. The MR-proADM level was 0.28 (0.22–0.40)?nmol/l in patients with coronary stenoses ≥50% (n?=?23) versus 0.33 (0.27–0.40)?nmol/l in patients with coronary stenoses <50% (n?=?83, P?=?0.59), 0.33 (0.26–0.40)?nmol/l in patients with soft plaques (n?=?56) versus 0.33 (0.25–0.41)?nmol/l in patients without soft plaques (n?=?50, P?=?0.73) and 0.33 (0.25–0.39)?nmol/l in patients with CACS?<200 (n?=?81) versus 0.32 (0.26–0.44)?nmol/l in patients with CACS?≥200 (n?=?26, P?=?0.77). In multivariate analysis, the MR-proADM level was a significant correlate of coronary artery stenoses [odds ratio (OR)?=?0.93; 95% confidence interval (CI) 0.86–0.99; P?=?0.026] and soft plaques (OR?=?0.94; 95% CI 0.90–0.99; P?=?0.015) but not of CACS (OR?=?0.98; 95% CI 0.93–1.03; P?=?0.36). A decreased MR-proADM level is an independent correlate of the presence of coronary artery disease and of soft atherosclerotic plaques. Patients with decreased MR-proADM levels may need invasive examinations to diagnose more severe forms of coronary artery disease. 相似文献
993.
994.
995.
996.
997.
998.
M Lee AC Choh EW Demerath B Towne RM Siervogel SA Czerwinski 《American journal of hypertension》2012,25(10):1131-1137
BackgroundObesity and arterial stiffness are associated, but fat distribution patterns may be more strongly related to arterial stiffness than general obesity because of the possible increased inflammation associated with increased abdominal adiposity. The aims of this study were to examine whether fat patterning is associated with arterial stiffness, and determine whether these associations are mediated by low-grade inflammation.MethodsAdult participants from the Fels Longitudinal Study (228 males and 254 females) were assessed for brachial-ankle pulse wave velocity (BaPWV) to determine arterial stiffness. Dual energy X-ray absorptiometry was used to estimate fat percentage of the trunk and legs (e.g., TRUNKFAT% and LEGFAT%). High-sensitivity C-reactive protein (hs-CRP) levels were assayed as a general marker of inflammation. General linear regression analyses were used.ResultsBaPWV was positively associated with TRUNKFAT% (r = 0.44 in men and r = 0.38 in women), whereas it was inversely related to LEGFAT% (r = -0.40 in men and r = -0.39 in women). In multiple regression analyses, each SD increase in TRUNKFAT% was associated with an ~1.03 m/s increase in BaPWV in both men and women. Each SD increase in LEGFAT% was related to a similar magnitude of decrease (1.03 m/s) in BaPWV in both sexes. The relationships of TRUNKFAT% and LEGFAT% with BaPWV were attenuated slightly when including hs-CRP in the models, but remained significant.ConclusionsWe found that trunk and leg fat are related to BaPWV in opposite directions when total body adiposity was accounted for. However, the associations between regional fat patterning and arterial stiffness did not appear to be mediated by low-grade inflammation.American Journal of Hypertension, 2012; doi:10.1038/ajh.2012.92. 相似文献
999.
Petter Brodin Stefan Gilg Lars Lundell Jonas Mattsson 《International journal of hematology》2012,96(6):798-800
Certain homeostatic functions are particularly important to the success of extensive surgery. For example metabolic homeostasis, inflammation and tissue repair, coagulation and immune defense against infection are all of great importance. In patients undergoing allogeneic hematopoietic stem cell transplantation (ASCT), the ability to mount adequate inflammatory responses is severely impaired. Thrombocytopenia is common making coagulation inadequate for any kind of invasive procedure, let alone extensive surgery. For this reason, abdominal surgery in neutropenic patients is associated with very high mortality rates of between 50 and 70 % [1]. Here, we describe a patient with high-risk myelofibrosis who required extensive abdominal surgery during the aplastic phase only 7 days after ASCT due to severe abdominal hemorrhage. This patient’s successful recovery shows that extensive surgery is possible even during the aplastic phase after ASCT. Interestingly, we also found that radical splenectomy 7 days after stem cell transplantation did not lead to any significant loss of infused stem cells. 相似文献
1000.
Rasche L Bernard C Topp MS Kapp M Duell J Wesemeier C Haralambieva E Maeder U Einsele H Knop S 《Annals of hematology》2012,91(7):1031-1037
Extramedullary (e) relapse in multiple myeloma(MM) has an adverse prognosis, but knowledge concerning biological features and preferred treatment is scarce. We screened the myeloma registry of our institution for eMM relapses and identified 24 cases among 357 patients (pts).Only 8% of eMM relapses occurred after initial therapy, but 54% occurred after third-line or subsequent therapy. Baseline molecular cytogenetics revealed high-risk features in 10 of 19 evaluable patients. Most frequently, eMM presented as soft tissue (67%) and organ involvement (25%) or malignant effusion (12.5%). Incidence of leptomeningeal/CNS involvement was 21%. At eMM relapse, bone marrow infiltration was absent in 46% and low in 21%. Ten eMM biopsies were available showing increased proliferation, i.e., Ki-67 of 67%(range, 30–90%) of all cancer cells. Pts received radiation therapy, dose-intense chemotherapy, novel agents, and allogeneic SCT resulting in an overall response rate of 54%. Median progression-free survival was 2 (95% CI 0.08–3.92) and median overall survival 7 months (95% CI 3.56–10.43), respectively,with only three patients being alive at 12 months from diagnosis. EMM relapse may present at any anatomical site with frequent CNS involvement. Biological features include increased proliferation and low rate of marrow involvement.Prognosis remains poor despite intensive treatment. 相似文献