Physicochemical stability of a preanesthetic mixture of hydroxyzine hydrochloride and atropine sulfate.

The stability of a combination of hydroxyzine hydrochloride and atropine sulfate stored in syringes was studied. Syringes containing the two drugs were stored at 25 C and 3 C for ten days and analyzed at specific time intervals. Absorption spectra, chromatographic characteristics and pH were determined. Results showed the admixture to be stable for ten days at room temperature or under refrigeration. The technique used would probably not detect any significant degradation of atropine sulfate unless the reaction occurred with the hydroxyzine hydrochloride.     

Suppressor pathways in tumor immunity: A requirement for Qa-1 positive tumor-bearer spleen t cells in suppression of the afferent immune response to tumor antigens

Spleen cells from mice bearing large methylcholanthrene (MCA)-induced sarcomas were injected intravenously into mice challenged in the hind footpads with heavily-irradiated cells from the same or a different sarcoma. As measured by [³H]-thymidine incorporation on day 5 or 6, cellular proliferation in the draining popliteal lymph nodes of these mice was significantly depressed as compared to control animals receiving normal spleen cells or medium intravenously. The suppression was found to be mediated by a Qa-1-positive, Thy-1-positive cell. It was relatively resistant to cyclophosphamide treatment (100 mg/kg). Furthermore, it had both antigen-specific and non-specific components. The findings are discussed in relation to a suppressor activator cellsuppressor acceptor cell pathway in the immunoregulation of tumor immunity.     

Spinal arachnoid cysts in children

Five cases of benign spinal arachnoid cysts in children are described with their clinical, neuroradiological, surgical and pathological findings. Intraspinal benign arachnoid cysts may be confidently diagnosed myelographically when there is complete or partial obstruction with multiple oily contrast/cerebrospinal fluid levels as in 3 cases in this series. The multiple fluid levels are probably produced by multiple cysts or a cyst loculated due to partial compression by arachnoid bands either related to the normal septum posticum, congenital or acquired adhesion rather than to trabeculations within the cyst. In this series, the origin of the cysts is considered to be congenital.     

Galactose Metabolism in a Patient with Hereditary Galactokinase Deficiency

Abstract. The ability of a galactokinase deficient patient to metabolize galactose, galactitol and galactonate was quantitated. In galactokinase deficiency, conversion of galactose to CO₂ is minimal. Apparently the defect is extensive, involving all tissues. Galactitol and galactonate, injected intravenously, were not metabolized. The administration of C-1 and C-2 labelled galactose resulted in ¹⁴CO₂ excretory patterns similar to that observed in uridyltransferase deficient mutants. The different fates of C-1 and C-2 observed in this galactokinase deficient patient give support to the existence of a direct oxidative pathway for galactose. Galactonate, although present in urine during the period of observation following injection of radioactive galactose failed to become labelled.