Experimental observations on the effect of amphepramone on the behavior,locomotion, pentetrazol seizures and electroencephalogram

Amphepramone, an anorectic agent, has been found to possess stimulant properties on the C.N.S. in animals, producing hypermotility and stereotyped movements which can be antagonized with neuroleptics.The stimulant activity of amphepramone observed in animals can be correlated with the amphetaminelike psychosis observed in humans.     

Destructive arthritis due to silicone: a foreign-body reaction

The authors report 3 cases of erosive arthritis resulting from a foreign-body reaction to a silicone implant in the wrist. No patient had a history of inflammatory arthritis. Radiographic changes included well-defined lytic lesions with thin, sclerotic margins, normal mineralization, and loss of volume of the implant. Pathologically, a destructive foreign-body reaction was seen, with intra- and extracellular silicone debris.