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Clinical features, complications and prognosis of 431 consecutivelyregistered Ethiopian Type 1 (insulin-dependent) diabetic patientsseen in the Diabetic Clinic in Yekatit 12 Hospital in AddisAbaba, Ethiopia, from 19761990 are reported. Male:femaleratio was 1.4:1; mean age at diagnosis was 18.1 years (confidenceinterval (CI) 1.6) in women and 21.4 (CI 1.2) in men. A historyof ketoacidosis at some time was present in 38 per cent, in11 per cent at diagnosis of diabetes. Tuberculosis was the mostcommon complicating illness, occurring at some time in 16.5per cent of patients. In addition, 9.5 per cent (CI 4 per cent)were known to have diabetic retinopathy, 6.0 per cent (CI 2per cent) nephropathy and 7.9 per cent (CI 2 per cent) neuropathyat their last clinic visit. During the 15 years of the study,9.7 per cent of the patients have died, with a mean durationof diabetes at death of 9.2 years (CI 1.8), and an overall mortalityrate of 15.5/1000 person-years of diabetes. Five-year survivalwas 96 per cent (CI 3 per cent), 15-year survival 82 per cent(CI 9 per cent), and 20-year survival 63 per cent (CI 17 percent), calculated using the Cox proportional hazards model;prognosis was better in those diagnosed at a younger age (p=0.029)and in those with a body mass index of > 19 kg/m2 on treatment(p=0.096). 相似文献
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X Sanjuan PL Fernandez A Castells V Castronovo F van den Brule FT Liu A Cardesa E Campo 《Gastroenterology》1997,113(6):1906-1915
BACKGROUND & AIMS: Galectins are beta-galactoside-binding proteins possibly involved in tumor progression. The aim of this study was to determine the pattern of galectin 3 and galectin 1 expression and involvement in colorectal cancer progression. METHODS: Galectin 3 expression was examined immunohistochemically in 39 samples of normal mucosae, 25 adenomas, 87 carcinomas, and 39 lymph node metastases. Galectin 1 was analyzed in 25 samples of mucosae, 15 adenomas, 25 carcinomas, and 11 metastases. Western blot analysis was also performed. RESULTS: All normal mucosae showed strong nuclear galectin 3 expression, which was down-regulated in the neoplastic progression, because only 60% of adenomas, 48% of carcinomas, and 44% of metastases were strongly positive (P < 0.0001). Cytoplasmic expression was down- regulated in adenomas (16%) but increased again in carcinomas (64%) (P < 0.0001). Galectin 1 expression was mainly detected in stromal cells and correlated with tumor progression from normal mucosae to adenomas and carcinomas (P < 0.0001). CONCLUSIONS: Galectin 3 expression is down- regulated in the initial stages of neoplastic progression, whereas a dissociated cytoplasmic expression increases in later phases of tumor progression. Galectin 1 in colorectal mucosa is predominantly a stromal product whose overexpression is associated with the neoplastic progression of colorectal cancer. (Gastroenterology 1997 Dec;113(6):1906-15) 相似文献
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Incidence and outcome of subarachnoid haemorrhage in the general and emergency department populations in Queensland from 2010 to 2014 下载免费PDF全文
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Danique RM Vlaskamp Steven FT Thijsen Johan Reimerink Pieter Hilkens Willem H Bouvy Sabine E Bantjes Bart JM Vlaminckx Hans Zaaijer Hans HTC van den Kerkhof Stijn FH Raven Chantal BEM Reusken 《Euro surveillance : bulletin européen sur les maladies transmissibles = European communicable disease bulletin》2020,25(46)
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Alexandra Markwell Rob Mitchell April L Wright Anthony FT Brown 《Emergency medicine Australasia : EMA》2020,32(3):520-524
EDs fulfil a frontline function during public health emergencies (PHEs) and will play a pivotal role during the COVID‐19 pandemic. This perspective article draws on qualitative data from a longitudinal, ethnographic study of an Australian tertiary ED to illustrate the clinical and ethical challenges faced by EDs during PHEs. Interview data collected during the 2014 Ebola Virus Disease PHE of International Concern suggest that ED clinicians have a strong sense of professional responsibility, but this can be compromised by increased visibility of risk and sub‐optimal engagement from hospital managers and public health authorities. The study exposes the tension between a healthcare worker's right to protection and a duty to provide treatment. Given the narrow window of opportunity to prepare for a surge of COVID‐19 presentations, there is an immediate need to reflect and learn from previous experiences. To maintain the confidence of ED clinicians, and minimise the risk of moral injury, hospital and public health authorities must urgently develop processes to support ethical healthcare delivery and ensure adequate resourcing of EDs. 相似文献