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排序方式: 共有422条查询结果,搜索用时 78 毫秒
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Ayako Nagai Ning Zou Masaru Kubota Chiaki Kojima Souichi Adachi Ikuya Usami Masayuki Okada Akihiko Tanizawa Keigo Hamahata Kousaku Matsubara Manryoku Higuchi Masue Imaizumi 《Pediatrics international》2012,54(2):272-276
Background: Fatigue in cancer survivors is a serious problem in pediatric oncology, but reports on this issue are limited, especially in Asian countries. Methods: Sixty‐three patients with acute lymphoblastic leukemia and 18 patients with acute myeloid leukemia who attended a follow‐up outpatient clinic were enrolled. Participants were required to be >8 years of age, in remission, and without any cancer treatment for at least the previous 1 year. A control group consisted of 243 subjects whose age and gender were matched with the patient group. A questionnaire consisting of 12 items was devised for fatigue measurement. Results: Principal factor analysis identified three dimensions, defined as physical fatigue, decreased function, and altered mood. The mean total and the three fatigue dimension scores tended to be higher in the control group, but significant differences between the scores were seen only in the total and physical fatigue scores. Multiple regression analysis indicated an association of present older age or shorter duration after completion of treatment with total and physical fatigue, and an association of presence of total body irradiation with decreased function. Conclusion: Pediatric leukemia survivors in Japan experience equal or less fatigue compared with that of controls in different fatigue dimensions. Elucidation of underlying mechanisms of cancer‐related fatigue including the differences of cultural background among different countries is necessary for future study of this issue. 相似文献
65.
Oomizu S Arikawa T Niki T Kadowaki T Ueno M Nishi N Yamauchi A Hirashima M 《Clinical immunology (Orlando, Fla.)》2012,143(1):51-58
Galectin-9 (Gal-9) ameliorates autoimmune reactions by suppressing Th17 cells while augmenting Foxp3+ regulatory T cells (Tregs). However, the exact mechanism of Gal-9-mediated immune modulation has been elusive. In a MOG-induced experimental allergic encephalomyelitis model using Gal-9−/− mice, we observed exacerbated inflammation and an increase in IL-17-producing Th17 cells balanced by a decrease in Foxp3+ Tregs. During in vitro Th17 skewing using TGF-β1 and IL-6, exogenous Gal-9 suppressed Th17 cell development and expanded Foxp3+ Tregs from naïve CD4 T cells in an IL-2-dependent manner. Although Gal-9 induced cell death in Tim3-expressing differentiated Th17 cells, Gal-9 suppressed Th17 development in a Tim-3-independent. Benzyl-α-GalNAc (an O-glycan biosynthesis inhibitor), but not swainsonine (a complex-type N-glycan biosynthesis inhibitor) abrogated Gal-9-mediated inhibition of Th17 development indicating that there is a linkage between Gal-9 and an unidentified glycoprotein(s) with O-linked β-galactosides that suppress Th17 development. 相似文献
66.
Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis 总被引:1,自引:0,他引:1
Seki M Oomizu S Sakata KM Sakata A Arikawa T Watanabe K Ito K Takeshita K Niki T Saita N Nishi N Yamauchi A Katoh S Matsukawa A Kuchroo V Hirashima M 《Clinical immunology (Orlando, Fla.)》2008,127(1):78-88
The effects of galectin-9 on a mouse collagen-induced arthritis (CIA) model were assessed to clarify whether galectin-9 suppresses CIA by regulating T cell immune responses. Galectin-9 suppressed CIA in a dose-dependent manner, and such suppression was observed even when treatment was started on 7 days after the booster, indicating its preventive and therapeutic effects. Galectin-9 induced the decreased levels of pro-inflammatory cytokines, IL-17, IL-12, and IFNgamma in the joint. Galectin-9 induced the decreased number of CD4(+) TIM-3(+) T cells in peripheral blood. Galectin-9-deficient mice became susceptible to CIA may be by increased number of CD4(+) TIM-3(+) T cells and decreased number of Treg cells. We further found that galectin-9 induces differentiation of naive T cells to Treg cells, and it suppresses differentiation to Th17 cells in vitro. The present results suggested that galectin-9 ameliorates CIA by suppressing the generation of Th17, promoting the induction of regulatory T cells. 相似文献
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Sae Ishimaru Yasuhiro Okamoto Chihaya Imai Hirotoshi Sakaguchi Tomohiko Taki Daisuke Hasegawa Yuko Cho Harumi Kakuda Hideki Sano Atsushi Manabe Toshihiko Imamura Motohiro Kato Yuki Arakawa Hidemi Shimonodan Atsushi Sato Souichi Suenobu Takeshi Inukai Arata Watanabe Yoshifumi Kawano Atsushi Kikuta Keizo Horibe Akira Ohara Katsuyoshi Koh 《Pediatrics international》2019,61(11):1103-1108
69.
Whole brain radiotherapy with volumetric‐modulated arc therapy for pediatric intracranial embryonic carcinoma prevents permanent alopecia
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70.
Fludarabine,cytarabine, granulocyte colony‐stimulating factor and idarubicin for relapsed childhood acute myeloid leukemia
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Hideki Nakayama Daisuke Tomizawa Shiro Tanaka Shotaro Iwamoto Akira Shimada Akiko M Saito Yuka Yamashita Hiroshi Moritake Kiminori Terui Takashi Taga Hidemasa Matsuo Yoshiyuki Kosaka Katsuyoshi Koh Hajime Hosoi Hidemitsu Kurosawa Keiichi Isoyama Keizo Horibe Shuki Mizutani Souichi Adachi 《Pediatrics international》2017,59(10):1046-1052