全文获取类型
收费全文 | 9302篇 |
免费 | 654篇 |
国内免费 | 24篇 |
专业分类
耳鼻咽喉 | 73篇 |
儿科学 | 413篇 |
妇产科学 | 213篇 |
基础医学 | 1214篇 |
口腔科学 | 242篇 |
临床医学 | 923篇 |
内科学 | 2052篇 |
皮肤病学 | 127篇 |
神经病学 | 824篇 |
特种医学 | 190篇 |
外科学 | 1152篇 |
综合类 | 159篇 |
一般理论 | 6篇 |
预防医学 | 986篇 |
眼科学 | 163篇 |
药学 | 655篇 |
2篇 | |
中国医学 | 39篇 |
肿瘤学 | 547篇 |
出版年
2023年 | 100篇 |
2022年 | 166篇 |
2021年 | 361篇 |
2020年 | 222篇 |
2019年 | 291篇 |
2018年 | 316篇 |
2017年 | 230篇 |
2016年 | 198篇 |
2015年 | 220篇 |
2014年 | 320篇 |
2013年 | 441篇 |
2012年 | 647篇 |
2011年 | 637篇 |
2010年 | 373篇 |
2009年 | 324篇 |
2008年 | 508篇 |
2007年 | 542篇 |
2006年 | 475篇 |
2005年 | 411篇 |
2004年 | 429篇 |
2003年 | 391篇 |
2002年 | 337篇 |
2001年 | 142篇 |
2000年 | 142篇 |
1999年 | 133篇 |
1998年 | 78篇 |
1997年 | 61篇 |
1996年 | 48篇 |
1995年 | 44篇 |
1994年 | 51篇 |
1993年 | 43篇 |
1992年 | 80篇 |
1991年 | 82篇 |
1990年 | 76篇 |
1989年 | 70篇 |
1988年 | 67篇 |
1987年 | 79篇 |
1986年 | 57篇 |
1985年 | 58篇 |
1984年 | 45篇 |
1983年 | 71篇 |
1982年 | 39篇 |
1981年 | 30篇 |
1980年 | 32篇 |
1979年 | 36篇 |
1978年 | 32篇 |
1976年 | 35篇 |
1974年 | 35篇 |
1970年 | 35篇 |
1969年 | 31篇 |
排序方式: 共有9980条查询结果,搜索用时 140 毫秒
111.
112.
Grace M 《Hospital pharmacy》1980,15(12):594-598
In recent years a great deal of attention has been paid to motivation and job satisfaction among hospital pharmacy practitioners. Institutional pharmacy managers should become more aware of ways in which they can motivate members of their staff. Specifically, Frederick Herzberg's Two-Factor Theory is discussed in reference to its origination, major tenets, and practical applications in institutional pharmacy practice settings. Principally, Herzberg's theory explains needs of workers in terms of extrinsic factors called "hygienes" and intrinsic factors called "motivators." The theory suggests that job satisfaction and dissatisfaction are not opposites but two separate dimensions. According to this theory, an employee will be motivated if the task allows for the following: 1)actual achievement, 2) recognition for achievement, 3) increased responsibility, 4) opportunity for growth (professionally), and 5) chance for advancement. It is concluded that some of these suggested applications can be useful to managers who are faced with low morale among the members of their staff. 相似文献
113.
114.
Double-stem silicone implants have been used to reconstruct destroyed hallux metatarsophalangeal joints (MTPJ) for many years. When smaller implants became available, they were used to reconstruct the lateral four MTPJ. An arthroplasty of all MTPJ was performed using these implants in 44 patients (72 feet) with rheumatoid arthritis (RA). The mean age of patients was 46 years (range, 21 to 66) and 84% were female. Previous surgery had been performed on 28% of the feet. All patients were followed prospectively for an average of 67 months (range, 36 to 111). The patients were evaluated clinically and radiographically; results were recorded on a standardized foot form that allowed computer analysis of the data. The results showed improvement in the hallux valgus angle from 41.6 degrees to 16.1 degrees postoperatively, with no loss of correction over time. Similarly, other forefoot deformities, such as plantar callus and lateral toe abnormalities, all improved both clinically and radiographically. The pain, walking, and function scores all improved, with the greatest improvement being pain relief. Radiographic analysis showed some evidence of fracture in seven hallux (9.7%) and nine lateral toe (3%) implants. Only three toes with implant fracture had some pain at follow-up examination. Three other lateral toe implants were removed for pain. There was no evidence of deep infection or silicone synovitis. Other complications included superficial infection, delayed wound healing, and second surgery for heterotopic bone excision.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
115.
116.
Cherian RA Haddaway MJ Davie MW McCall IW Cassar-Pullicino VN 《The British journal of radiology》2000,73(871):720-726
Although bone density may be increased in bone that is affected by Paget's disease, density changes in cortical and trabecular bone and the effect on bone that is apparently unaffected by Paget's disease are relatively unexplored. We have investigated 81 vertebrae (28 affected, 53 unaffected) in 27 patients with Paget's disease, by dual X-ray absorptiometry (DXA) and by quantitative CT (QCT) bone density measurements of trabecular and cortical bone. DXA bone density was high (mean z-score = 1.62, p < 0.001) in vertebrae affected by Paget's disease, but not significantly different from normal in unaffected vertebrae (mean z-score = 0.07, ns). Mean QCT z-score in Paget's vertebrae was 2.07 (p = 0.009) for cortical bone and 1.37 (p = 0.008) for trabecular bone. DXA correlated with QCT cortical values in affected and unaffected bone (r = 0.8 and 0.56, respectively), and with QCT trabecular values (r = 0.72 and 0.48, respectively). There was no significant difference in the slopes for the correlations in affected or unaffected bone. Cortical QCT values are underestimated in Paget's disease compared with physical measurements of density, owing to the computer algorithm used. High DXA values may alert to the possibility of Paget's disease, especially if the value deviates from the expected normal sequence in lumbar vertebrae. Osteoporotic vertebrae may be overlooked if the average value of bone mineral density is taken in the lumbar spine without reviewing each vertebra. 相似文献
117.
118.
Janet Martin Stephen M. Stribbling Grace K. Poon Richard H. J. Begent Mark Napier Surinder K. Sharma C. J. Springer 《Cancer chemotherapy and pharmacology》1997,40(3):189-201
Antibody-directed enzyme prodrug therapy (ADEPT) was administered to ten patients in a phase I clinical trial. The aim was
to measure plasma levels of the prodrug 4-[(2-chloroethyl)(2-mesyloxyethyl) amino] benzoyl-l-glutamic acid (CMDA) and the bifunctional alkylating drug (CJS11) released from it by the action of tumour-localised carboxypeptidase
G2 (CPG2) enzyme. New techniques were developed to extract the prodrug and drug from plasma by solid-phase adsorbtion and
elution and to measure CPG2 activity in plasma and tissue. All extracts were analysed by high-performance liquid chromatography
(HPLC) and liquid chromatography-mass spectrometry (LC-MS). CPG2 activity was found in metastatic tumour biopsies but not
in normal tissue, indicating that localisation had been successful. The clearing agent SB43-gal, given at 46.5 mg/m2, achieved the aim of clearing non-tumour-localised enzyme in the circulation, indicating that conversion of prodrug to drug
could take place only at the site of localised conjugate. Plasma prodrug did not always remain above its required threshold
of 3 μM for the “therapeutic window” of 120 min after dosing, but the presence of residual prodrug after the first administration
of each day indicated that this could be achieved during the remaining four doses over the following 8 h. Despite considerable
inter-patient prodrug plasma concentration variability, the elimination half-life of the prodrug was remarkably reproducible
at 18 ± 8 min. Rapid appearance of the drug in plasma indicated that successful conversion from the prodrug had taken place,
but also undesirable leakback from the site of localisation into the bloodstream. However, drug plasma levels fell rapidly
by at least 50% at between 10 and 60 min with a half-life of 36 ± 14 min. Analysis of the plasma extracts by LC/MS indicated
that this technique might be used to confirm qualitatively the presence of prodrug, drug and their metabolites.
Received: 21 July 1996 / Accepted: 20 January 1997 相似文献
119.
Kiely PD Tierney S Barry M Delaney PV Drumm J Grace PA 《Irish journal of medical science》2000,169(2):100-102
Background
It has been suggested that only specialist paediatric surgeons should manage infantile hypertrophic pyloric stenosis (IMPS). 相似文献120.
A growing body of evidence suggests that structural changes in the cortex may disrupt dopaminergic transmission in circuits involving the prefrontal cortex (PFC) and may contribute to the etiology of schizophrenia. In this study, we utilize a rodent model of neonatal disruption of cortical development using prenatal administration of the mitotoxin methylazoxymethanol acetate (MAM). Using intracellular recordings in vivo, we compare the physiology of prefrontal cortical neurons and their responses to topical administration of dopamine (DA) in intact animals and adult rats treated prenatally with MAM. Topical administration of DA hyperpolarized the membrane potential (MP) and decreased the firing rate of neurons recorded in deep layers of the PFC in intact animals. Furthermore, electrical stimulation of the VTA evoked fast onset epsps or long-lasting depolarizations in PFC neurons. In comparison, PFC neurons recorded in MAM-treated animals had significantly faster baseline firing rates. Moreover, topical administration of DA did not affect the MP or firing rate of the neurons in MAM-treated animals. However, MAM-treated animals exhibited an increase in the percentage of neurons responding with long-lasting depolarizations to stimulation of the VTA. The results of this study indicate that PFC neurons in the MAM-treated rats are not responsive to DA administered superficially, while at the same time exhibit greater responsiveness to VTA stimulation. These results are consistent with a rewiring of the corticolimbic system in response to neurodevelopmental insults. 相似文献