全文获取类型
收费全文 | 3266篇 |
免费 | 157篇 |
国内免费 | 15篇 |
专业分类
耳鼻咽喉 | 20篇 |
儿科学 | 69篇 |
妇产科学 | 44篇 |
基础医学 | 452篇 |
口腔科学 | 73篇 |
临床医学 | 301篇 |
内科学 | 551篇 |
皮肤病学 | 117篇 |
神经病学 | 454篇 |
特种医学 | 219篇 |
外科学 | 446篇 |
综合类 | 14篇 |
预防医学 | 114篇 |
眼科学 | 120篇 |
药学 | 239篇 |
中国医学 | 6篇 |
肿瘤学 | 199篇 |
出版年
2023年 | 12篇 |
2022年 | 12篇 |
2021年 | 47篇 |
2020年 | 40篇 |
2019年 | 63篇 |
2018年 | 54篇 |
2017年 | 59篇 |
2016年 | 61篇 |
2015年 | 85篇 |
2014年 | 102篇 |
2013年 | 119篇 |
2012年 | 171篇 |
2011年 | 144篇 |
2010年 | 91篇 |
2009年 | 83篇 |
2008年 | 191篇 |
2007年 | 186篇 |
2006年 | 193篇 |
2005年 | 189篇 |
2004年 | 191篇 |
2003年 | 192篇 |
2002年 | 178篇 |
2001年 | 84篇 |
2000年 | 47篇 |
1999年 | 73篇 |
1998年 | 42篇 |
1997年 | 35篇 |
1996年 | 27篇 |
1995年 | 29篇 |
1994年 | 28篇 |
1993年 | 25篇 |
1992年 | 33篇 |
1991年 | 16篇 |
1990年 | 23篇 |
1989年 | 24篇 |
1988年 | 29篇 |
1987年 | 22篇 |
1986年 | 14篇 |
1985年 | 17篇 |
1984年 | 17篇 |
1983年 | 12篇 |
1980年 | 13篇 |
1979年 | 12篇 |
1978年 | 16篇 |
1977年 | 9篇 |
1972年 | 9篇 |
1967年 | 10篇 |
1933年 | 9篇 |
1931年 | 8篇 |
1928年 | 9篇 |
排序方式: 共有3438条查询结果,搜索用时 125 毫秒
71.
72.
73.
74.
Sensory perceptions of individuals exposed to the static field of a 7T MRI: A controlled blinded study 下载免费PDF全文
75.
Pre‐clinical heterotopic intrathoracic heart xenotransplantation: a possibly useful clinical technique 下载免费PDF全文
Bruno Reichart Stefan Buchholz Fabian Werner Isabelle Lutzmann Michael Schmoeckel Andreas Bauer Michael Thormann Martin Langenmayer Nadja Herbach Heike Pohla Rudolf Herzog Christopher G. A. McGregor David Ayares Eckhard Wolf Nikolai Klymiuk Andrea Baehr Alexander Kind Christian Hagl Ute Ganswindt Claus Belka Paolo Brenner 《Xenotransplantation》2015,22(6):427-442
76.
Schütt P Ebeling P Buttkereit U Brandhorst D Opalka B Poser M Müller S Flasshove M Moritz T Seeber S Nowrousian MR 《Annals of hematology》2005,84(9):594-600
The aim of this study was to assess the side effects and the efficacy of thalidomide alone or in combination with dexamethasone in relapsed multiple myeloma (MM) and to evaluate possible predictive factors for response rate and survival. Twenty-nine pretreated patients were enrolled, including 13 patients with a relapse after high-dose chemotherapy. The median number of relapses was 3 (range: 1–7). Twenty-two patients received thalidomide in combination with dexamethasone and seven patients thalidomide alone. The dosage of thalidomide was 400 mg/day and the dosage of dexamethasone 20 mg/m2 daily for 4 consecutive days every 3 weeks. Cycles of dexamethasone were given until maximal decline of myeloma protein was achieved, whereas therapy with thalidomide was maintained until disease progression. Responses occurred in 62% of patients, including 5 (17%) complete remissions and 13 (45%) partial remissions. The median event-free survival (EFS) was 7.2 months and the median overall survival (OS) 26.1 months. In multivariate analysis, pretreatment serum levels of soluble interleukin-2 receptor (sIL-2R) were a significant prognostic factor for EFS, and those of 2-microglobulin (2M) and sIL-2R for OS. Serum levels of sIL-2R significantly increased after 3 weeks of treatment in 89% of patients, possibly representing lymphocyte activation induced by thalidomide. Two patients died of septic complications within 3 months after starting treatment with thalidomide and dexamethasone and one patient of herpes encephalitis after 26 months of treatment with thalidomide alone. Also, one case of pneumonia and one case of deep venous thrombosis of the lower limb occurred. Other side effects were somnolence, peripheral neuropathy, and bradycardia occurring in 35, 55, 38 and 55% of patients, respectively. The combination of thalidomide and dexamethasone is an effective therapy in heavily pretreated myeloma patients with a high response rate and acceptable toxicities. A powerful predictive factor both for EFS and OS was the pretreatment serum level of sIL-2R. 相似文献
77.
Fate of goblet cells in experimental colitis 总被引:3,自引:0,他引:3
Makkink MK Schwerbrock NM Mähler M Boshuizen JA Renes IB Cornberg M Hedrich HJ Einerhand AW Büller HA Wagner S Enss ML Dekker J 《Digestive diseases and sciences》2002,47(10):2286-2297
We sought to correlate the characteristic changes in goblet cell morphology in the chronically inflamed large intestine of IL10
–/– mice to specific changes in goblet cell gene expression. In healthy as well as IL10
–/– mice, marked differences were found among the large intestinal regions in goblet cell morphology and gene expression. The mucin Muc2, which is a major determinant of goblet cell morphology, was expressed in most goblet cells, yet only in cells staining positive for both Alcian blue and high iron diamine. TFF3 was expressed in only a small subset of goblet cells. Inflamed colon of IL10
–/– mice still contained high numbers of small, hypotrophic goblet cells with similar histochemical staining and Muc2 and TFF3 expression patterns, contradicting the often reported goblet cell depletion in colitis. Quantitatively, the Muc2 and TFF3 levels remained relatively stabile in IL10
–/– mice. Muc2 in distal IL10
–/– colon contained significantly less sulfate residues than in controls, which may compromise its protective properties. 相似文献
78.
79.
80.
Expression of bone sialoprotein and bone morphogenetic protein-2 in calcific aortic stenosis 总被引:1,自引:0,他引:1
Kaden JJ Bickelhaupt S Grobholz R Vahl CF Hagl S Brueckmann M Haase KK Dempfle CE Borggrefe M 《The Journal of heart valve disease》2004,13(4):560-566
BACKGROUND AND AIM OF THE STUDY: Calcific aortic stenosis, the major heart valve disease encountered in the elderly, leads to massive calcium deposition in the valve leaflets that morphologically resembles bone formation. Recent studies have demonstrated the expression of various bone-associated proteins in stenotic valves, suggesting that valvular calcification may be an actively regulated process. Bone sialoprotein (BSP), a non-collagenous bone matrix protein, and bone morphogenetic protein-2 (BMP-2), a member of the transforming growth factor cytokine superfamily, are known to participate in the regulation of bone development and maturation. Their pathogenetic role in calcific aortic stenosis is unknown. METHODS: Using an immunoperoxidase technique and antibodies against BSP and BMP-2, the expression of BSP and BMP-2 was examined in 16 human aortic valves with calcific aortic stenosis obtained at valve replacement, and in seven normal autopsy controls without signs of aortic stenosis. RESULTS: By semiquantitative scoring, stenotic valves showed a significantly increased staining of BSP in cells and extracellular matrix as compared to control valves (2.7 +/- 0.1 versus 0.6 +/- 0.2 score units, p <0.001). Marked BMP-2 expression was detected in stenotic valves, mostly in cell-rich areas associated with focal calcium deposits, but no specific staining for BMP-2 was detected in control valves (1.5 +/- 0.2 versus 0.0 +/- 0.0 score units, p <0.001). CONCLUSION: These results demonstrate for the first time that BSP and BMP-2 are differentially expressed in normal aortic valves and in aortic stenosis, thereby supporting the concept that valvular calcification might be based on an actively regulated process involving BSP and BMP-2. 相似文献