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191.
Dental material artifacts on MR images 总被引:2,自引:0,他引:2
Hinshaw DB Jr; Holshouser BA; Engstrom HI; Tjan AH; Christiansen EL; Catelli WF 《Radiology》1988,166(3):777-779
Magnetic resonance (MR) imaging of the head and neck is becoming an important aid in evaluating pathologic conditions of the brain, midface, and pharynx. Certain dental materials cause artifacts during MR imaging of the lower midface. These artifacts can obscure the normal anatomy. This study describes the degree of artifact production caused by various materials commonly used in dental restorations. Of the materials tested, those causing artifacts were made of stainless steel, such as orthodontic bands used for braces, and pins or posts that are commonly drilled into teeth to provide structure or stability before filling. Materials used as temporary or permanent fillings or crowns--such as amalgam, gold alloy, aluminum, microfilled resin, and polyvinyl acrylics--did not cause artifacts in the images. 相似文献
192.
193.
Effects of surgery on the cell kinetics of residual tumor. 总被引:2,自引:0,他引:2
Noncurative excision of a primary sc Lewis lung tumor performed on Day 7 or later results in an increase in the thymidine index and growth rate with minimal changes in the cell cycle parameters of the lung metastases. The stimulation of the lung nodules is accompanied by a small but consistent decrease in median lifespan. Sham surgery performed on Day 3 or later also results in a decrease in median lifespan and an increase in the thymidine index of the undisturbed primary tumor. Artifical metastases (10(6) cells iv) are inhibited by the presence of a second (sc) implant and the median lifespan of the doubly implanted mice exceeds that of mice bearing iv implants only. In mice bearing widely metastasized Lewis lung carcinoma, surgery alone may have a detrimental effect on life expectancy, but the residual tumor foci, stimulated to more rapid growth, should be appropriate targets for adjuvant chemotherapy. 相似文献
194.
Proliferation of early human myeloid precursors induced by interleukin- 1 and recombinant soluble CD23 总被引:8,自引:0,他引:8
Mossalayi MD; Arock M; Bertho JM; Blanc C; Dalloul AH; Hofstetter H; Sarfati M; Delespesse G; Debre P 《Blood》1990,75(10):1924-1927
Low affinity Fc epsilon receptors (Fc epsilon RII/CD23) or their soluble fragments have various biologic effects on B- and T-cell lineages. In this study, we have assessed the effect of recombinant soluble CD23 (rsCD23) on the proliferation of human bone marrow (BM)- derived myeloid precursors with or without recombinant interleukin-1 (rIL-1) addition. Non-adherent CD2- or CD34+ BM cell subsets were used as target cells. Our results show that rsCD23 in synergy with rIL-1 displays an interleukin-3-like activity as it promotes the proliferation of multipotential marrow precursors. This effect was abolished by anti-CD23 addition to these cultures, but was not affected by anti-IL-3 monoclonal antibody. Furthermore, sequential study indicates that rIL-1 induces bone marrow cell responsiveness to rsCD23. 相似文献
195.
Biallelic expression of the IGF2 gene in human breast disease 总被引:5,自引:1,他引:4
McCann AH; Miller N; O'Meara A; Pedersen I; Keogh K; Gorey T; Dervan PA 《Human molecular genetics》1996,5(8):1123-1127
We examined the imprinting status of the insulin-like growth factor II gene
(IGF2) in a series of 20 human breast disease samples to determine if
disrupted imprinting (as evidenced by biallelic expression), was a
demonstrable mechanism of altered gene expression. These samples included
benign (n = 7) and malignant breast lesions (n = 13). Biallelic expression
of IGF2 was detectable in 67% of benign and 60% of malignant informative
breast lesions. Three informative reduction mastectomies displayed normal
IGF2 imprinting. The presence of this alteration in human breast tissue is
a novel finding, and may contribute to tumorigenesis, possibly by favouring
an enhanced proliferative milieu, during which additional mutations could
occur.
相似文献
196.
Wagner TM; Hirtenlehner K; Shen P; Moeslinger R; Muhr D; Fleischmann E; Concin H; Doeller W; Haid A; Lang AH; Mayer P; Petru E; Ropp E; Langbauer G; Kubista E; Scheiner O; Underhill P; Mountain J; Stierer M; Zielinski C; Oefner P 《Human molecular genetics》1999,8(3):413-423
The aim of this study was to evaluate the prevalence of simple sequence
variation in the BRCA2 gene. To this end, 71 breast and breast-ovarian
cancer (HBC/HBOC) families along with 95 control individuals from a wide
range of ethnicities were analyzed by means of denaturing high- performance
liquid chromatography (DHPLC) and direct sequence analysis. In the coding
(10 257 bp) and non-coding (2799 bp) sequences of BRCA2, 82 sequence
variants were identified. Three different, apparently disease-associated
BRCA2 mutations were found in six HBC/HBOC families (8%): two splice site
mutations in introns 5 and 21, and one frameshift mutation in exon 11. In
the coding region, 53 simple sequence variants were found: 35 missense
mutations, one 2 bp deletion (CT) resulting in a stop at codon 3364, one
nonsense mutation with a stop at codon 3326, one deletion of a complete
codon (AAA) resulting in the loss of leucine, and 15 silent mutations. In
the non-coding region, 26 polymorphisms were detected. Of the 79 sequence
variants that were not obviously disease-associated, eight were detected
only in HBC/HBOC families. The remaining 71 variants were identified in
both HBC/HBOC families and control individuals. Sixty three sequence
variants (80%) were specific for a continent. Forty two percent (33 out of
79) of the sequence variants were detected exclusively in Africa, though
only 13% of the 332 chromosomes screened were of African origin. Our data
indicate that, in BRCA2, simple sequence variation is frequent [in the
coding region 1 in 194 bp (straight theta = 2.2 x 10(-4)), and in the
non-coding region 1 in 108 bp (straight theta = 4.4 x 10(-4)),
respectively].
相似文献
197.
Ros PR; Goodman ZD; Ishak KG; Dachman AH; Olmsted WW; Hartman DS; Lichtenstein JE 《Radiology》1986,158(3):619-624
Mesenchymal hamartoma of the liver (MHL) is an uncommon cystic mass of infancy that is a developmental anomaly rather than a neoplasm. Fourteen cases of MHL were retrospectively reviewed. Grossly, MHL is a solitary mass with cystic spaces of variable size. Patients are seen initially with painless progressive abdominal enlargement. On plain films, MHL appears as a large, noncalcified mass in the right upper quadrant. Scintigraphy is helpful in confirming its hepatic origin. Ultrasonography and computed tomography demonstrate a large multiloculated mass with considerable variation in the size of septa and cystic spaces. Angiographically, MHL is avascular or hypovascular. Recognition of these radiographic findings allows a correct diagnosis to be made in many cases. With resection, the prognosis is excellent. 相似文献
198.
Neural crest tumors: I-123 MIBG imaging in children 总被引:3,自引:0,他引:3
Paltiel HJ; Gelfand MJ; Elgazzar AH; Washburn LC; Harris RE; Masters PR; Golsch GJ 《Radiology》1994,190(1):117
199.
200.