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71.
Shunsuke Ohshima 《Journal of hepato-biliary-pancreatic sciences》2014,21(4):235-238
In recent years, there has been an active movement to ensure the greater safety of actual surgeries, by simulating it preoperatively with the use of three‐dimensional image visualization technologies. Along with this movement, the Ministry of Health, Labour and Welfare has named “Image‐supported navigation in hepatectomy” as part of advanced medical techniques. This method aims to improve the safety during a surgery by calculating the volume of the liver dominated by each blood vessel or simulating, prior to surgery, the volume of resection zone or the remaining liver volume. These calculations and simulations are carried out using the three‐dimensional images produced by extractions of the liver, vascular and tumor regions from the computed tomography images, which were collected using the tomography apparatus prior to hepatectomy. In order to facilitate the achievement of such preoperative simulations, the volume analyzer SYNAPSE VINCENT (VINCENT, hereafter) by Fujifilm, in its Liver Analysis Application, comes equipped with unique features. This paper will introduce the technologies behind those unique features and provide a direction for future research and developments. 相似文献
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Takashi Saeki Motoaki Nakamura Nobuhide Hirai Yoshihiro Noda Shunsuke Hayasaka Hideo Iwanari Yoshio Hirayasu 《Brain stimulation》2013,6(3):390-396
BackgroundThe effects of repetitive transcranial magnetic stimulation (rTMS) on sleep structure in major depression are currently unknown.ObjectiveTo determine the effects of prefrontal rTMS on sleep electroencephalography (EEG) in major depression.MethodsIn this open-label pilot study, twelve male patients with relatively mild depression, who had been medication-resistant, underwent 10 daily rTMS sessions over the left dorsolateral prefrontal cortex (DLPFC). Polysomnographic (PSG) data were recorded over four nights: Adaptation, Baseline, Post-1 (after the fifth rTMS session), and Post-2 (after the tenth rTMS session). Discrete Fourier Transform (DFT) band power analyses were performed to quantify delta and sigma band activities during Stages II–IV, and determine time courses of these activities between Baseline and Post-1 (first five sessions) and between Post-1 and Post-2 (last five sessions).ResultsPost-hoc tests based on a three-way ANOVA model indicated significant delta power increase at F3 (t11 = ?2.762, P = 0.018) during the first five sessions; however, sigma power was unchanged. No significant band power changes were observed during the second half. Stages II–IV (percent total sleep time) increased significantly during the first half (t12 = ?2.43, P = 0.033). No other significant changes in sleep parameters or clinical correlations were observed.ConclusionsThe first five sessions of high frequency rTMS to the left DLPFC increase slow-wave activity (SWA) at F3, possibly reflecting locally enhanced synaptic plasticity induced by rTMS. This increased activity was not observed during the last half, possibly due to a homeostatic regulation mechanism intrinsic to SWA. 相似文献
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Tomoko Katsui Taniyama Chigusa Morizane Kohei Nakachi Satoshi Nara Hideki Ueno Shunsuke Kondo Tomoo Kosuge Kazuaki Shimada Minoru Esaki Masafumi Ikeda Shuichi Mitsunaga Taira Kinoshita Masaru Konishi Shinichiro Takahashi Takuji Okusaka 《Pancreatology》2012,12(5):428-433
ObjectivesA global consensus on how to treat recurrent pancreatic cancer after adjuvant chemotherapy with gemcitabine (ADJ-GEM) does not exist.MethodsWe retrospectively reviewed the clinical data of 41 patients with recurrences who were subsequently treated with chemotherapy.ResultsThe patients were divided into two groups according to the time until recurrence after the completion of ADJ-GEM (ADJ-Rec): patients with an ADJ-Rec < 6 months (n = 25) and those with an ADJ-Rec ≥ 6 months (n = 16). The disease control rate, the progression-free survival after treatment for recurrence and the overall survival after recurrence for these two groups were 68 and 94% (P = 0.066), 5.5 and 8.2 months (P = 0.186), and 13.7 and 19.8 months (P = 0.009), respectively. Furthermore, we divided the patients with an ADJ-Rec < 6 months into two groups: patients treated with gemcitabine (n = 6) and those treated with alternative regimens including fluoropyrimidine-containing regimens (n = 19) for recurrent disease. Patients treated with the alternative regimens had a better outcome than those treated with gemcitabine.ConclusionsFluoropyrimidine-containing regimens may be a reasonable strategy for recurrent disease after ADJ-GEM and an ADJ-Rec < 6 months. 相似文献
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Hiroaki Nakashima Yasutsugu Yukawa Shiro Imagama Keigo Ito Testuro Hida Masaaki Machino Shunsuke Kanbara Daigo Morita Nobuyuki Hamajima Naoki Ishiguro Fumihiko Kato 《European spine journal》2013,22(7):1526-1532