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971.
Endoscopic Removal of Gastric Lipoma: Diagnostic Value of Endoscopic Ultrasonography 总被引:1,自引:0,他引:1
Shotaro Nakamura M.D. Mitsuo Iida M.D. Hiroshi Suekane M.D. Toshiyuki Matsui M.D. Takashi Yao M.D. Masatoshi Fujishima M.D. 《The American journal of gastroenterology》1991,86(5):619-621
A 47-yr-old male with gastric lipoma is presented. X-ray and endoscopic examinations revealed a submucosal tumor on the posterior wall of the gastric antrum. Endoscopic ultrasonography demonstrated the hyperechoic mass in the submucosa without continuity to the muscularis propria, by which the lesion was diagnosed as lipoma. The lesion was successfully removed by endoscopic polypectomy without complications. The cross-sections of the removed specimens were quite consistent with the ultrasonographic findings. Endoscopic ultrasonography is valuable in assessing the exact extent of the tumor and in determining whether or not endoscopic polypectomy is called for. 相似文献
972.
Hiroki Ikeda Tsunamasa Watanabe Masanori Atsukawa Hidenori Toyoda Koichi Takaguchi Makoto Nakamuta Nobuyuki Matsumoto Chiaki Okuse Toshifumi Tada Akemi Tsutsui Naoki Yamashita Chisa Kondo Korenobu Hayama Keizo Kato Norio Itokawa Taeang Arai Noritomo Shimada Toru Asano Haruki Uojima Chikara Ogawa Shigeru Mikami Tadashi Ikegami Shinya Fukunishi Akira Asai Etsuko Iio Akihito Tsubota Atsushi Hiraoka Akito Nozaki Hironao Okubo Yoshihiko Tachi Akio Moriya Tsunekazu Oikawa Yoshihiro Matsumoto Shuichi Tsuruoka Joji Tani Kan Kikuchi Katsuhiko Iwakiri Yasuhito Tanaka Takashi Kumada 《Journal of viral hepatitis》2019,26(11):1266-1275
Based on high efficacy and safety demonstrated in clinical trials, treatment with glecaprevir/pibrentasvir (G/P) for 8 weeks is recommended for hepatitis C virus (HCV)–infected patients who are direct‐acting antiviral (DAA) naïve, genotype 1 or 2, and noncirrhotic. The aim of this study was to validate real‐world experience with 8‐week G/P treatment in Japan. We conducted a prospective observational cohort study in 554 patients who underwent 8‐week treatment from among 1,022 patients who initiated G/P therapy. The majority (54.5%) were male, with a median age of 66 years, and HCV genotype distribution was genotype 1, 43.8%; genotype 2, 55.3%; and mixed subtype, 0.9%. Overall, the sustained virologic response rate at 12 weeks (SVR12) was 92.8% (530/571) in the intention‐to‐treat population and 99.3% (526/530) in the per‐protocol population. The SVR12 rates by subgroups were as follows: subtype 1a, 100% (6/6); 1b, 100% (189/189); 2a, 99.3% (150/151); 2b, 99.0% (103/104); and mixed subtype, 50% (2/4). Among four patients with virologic failure following 8‐week treatment with G/P, none had baseline polymorphisms or treatment‐emergent amino acid substitutions in NS3. However, 2 of 4 patients with virologic failure had treatment‐emergent amino acid substitutions in NS5A. Adverse events (AEs) were reported in 21.5% of patients and 1.2% of patients discontinued due to drug‐related AEs. In conclusion, G/P treatment for 8 weeks was safe and effective for DAA‐naïve noncirrhotic genotype 1 or 2 patients in a real‐world clinical setting in Japan. 相似文献
973.
Muraki Y Enomoto S Iguchi M Fujishiro M Yahagi N Ichinose M 《World journal of gastrointestinal endoscopy》2012,4(1):1-8
Endoscopic submucosal dissection (ESD), an endoscopic procedure for the treatment of gastric epithelial neoplasia without lymph node metastases, spread rapidly, primarily in Japan, starting in the late 1990s. ESD enables en bloc resection of lesions that are difficult to resect using conventional endoscopic mucosal resection (EMR). However, in comparison to EMR, ESD requires a high level of endoscopic competence and a longer resection time. Thus, ESD is associated with a higher risk of adverse events, including intraoperative and postoperative bleeding and gastrointestinal perforation. In particular, because of a higher incidence of intraoperative bleeding with mucosal incision and submucosal dissection, which are distinctive endoscopic procedures in ESD, a strategy for endoscopic hemostasis, mainly by thermo-coagulation hemostasis using hemostatic forceps, is important. In addition, because of iatrogenic artificial ulcers that always form after ESD, endoscopic hemostasis and appropriate pharma-cotherapy during the healing process are essential. 相似文献
974.
975.
Takayoshi Kaida Hiromitsu Hayashi Hiroki Sato Shotaro Kinoshita Takashi Matsumoto Yuta Shiraishi Yuki Kitano Takaaki Higashi Katsunori Imai Yo-ichi Yamashita Hideo Baba 《World journal of hepatology》2022,14(1):234-243
BACKGROUNDLaparoscopic surgery has been introduced as a minimally invasive technique for the treatment of various field. However, there are few reports that have scientifically investigated the minimally invasive nature of laparoscopic liver resection (LLR).AIMTo investigate whether LLR is scientifically less invasive than open liver resection.METHODSDuring December 2011 to April 2015, blood samples were obtained from 30 patients who treated with laparoscopic (n = 10, 33%) or open (n = 20, 67%) partial liver resection for liver tumor. The levels of serum interleukin-6 (IL-6) and plasma thrombospondin-1 (TSP-1) were measured using ELISA kit at four time points including preoperative, immediate after operation, postoperative day 1 (POD1) and POD3. Then, we investigated the impact of the operative approaches during partial hepatectomy on the clinical time course including IL-6 and TSP-1.RESULTSSerum level of IL-6 on POD1 in laparoscopic hepatectomy was significantly lower than those in open hepatectomy (8.7 vs 30.3 pg/mL, respectively) (P = 0.003). Plasma level of TSP-1 on POD3 in laparoscopic hepatectomy was significantly higher than those in open hepatectomy (1704.0 vs 548.3 ng/mL, respectively) (P = 0.009), and have already recovered to preoperative level in laparoscopic approach. In patients with higher IL-6 Levels on POD1, plasma level of TSP-1 on POD3 was significantly lower than those in patients with lower IL-6 Levels on POD1. Multivariate analysis showed that open approach was the only independent factor related to higher level of IL-6 on POD1 [odds ratio (OR), 7.48; 95% confidence interval (CI): 1.28-63.3; P = 0.02]. Furthermore, the higher level of serum IL-6 on POD1 was significantly associated with lower level of plasm TSP-1 on POD3 (OR, 5.32; 95%CI: 1.08-32.2; P = 0.04) in multivariate analysis. CONCLUSIONIn partial hepatectomy, laparoscopic approach might be minimally invasive surgery with less IL-6 production compared to open approach. 相似文献
976.
Shinjiro Inomata Daisuke Morihara Akira Anan Eri Yamauchi Ryo Yamauchi Kazuhide Takata Takashi Tanaka Keiji Yokoyama Yasuaki Takeyama Makoto Irie Satoshi Shakado Tetsuro Sohda Shotaro Sakisaka Fumihito Hirai 《Internal medicine (Tokyo, Japan)》2022,61(4):461
Objective Hepatitis C virus (HCV) eradication is associated with decreased serum ferritin and increased serum low-density lipoprotein-cholesterol (LDL-C) levels, although the mechanisms underlying these changes remain unclear. This study aimed to identify the mechanisms underlying the changes in iron and lipid metabolism after HCV eradication. Methods We retrospectively investigated iron and lipid metabolism changes in 22 patients with chronic hepatitis or compensated liver cirrhosis with HCV genotype 1b infection after HCV eradication. We measured the serum erythroferrone (ERFE) levels to assess the association with these metabolic changes. Patients were administered ledipasvir 90 mg and sofosbuvir 400 mg once daily for 12 weeks and were observed for 12 more weeks to evaluate the sustained virological response. Results Half of the patients were men. At baseline, the serum ferritin and ERFE levels were elevated, while the serum LDL-C levels were within the normal range. All patients achieved a sustained virological response at 24 weeks; furthermore, the serum ferritin and ERFE levels were significantly decreased, and the serum LDL-C levels were significantly increased at 24 weeks from baseline (p<0.001, all). In men, a decrease in serum ERFE levels was correlated with changes in the serum ferritin and LDL-C levels (r=0.78, p<0.01; r=-0.76, p<0.01, respectively). In addition, a decrease in the serum ferritin levels was correlated with an increase in the serum LDL-C levels (r=-0.89, p<0.001). These correlations were not observed in women. Conclusion Our results suggest a possible association between iron and lipid metabolism changes and the involvement of ERFE after HCV eradication in men as well as potential sex-related differences. 相似文献
977.
An Autopsy Case of Ki-1 Lymphoma Associated with Hepatic Failure 总被引:2,自引:0,他引:2
Norihisa Suzuki M.D. Hiroshi Tsuji M.D. Shotaro Nakamura M.D. Hiroshi Asabe M.D. Katsuo Sueishi M.D. Masatoshi Fujishima M.D. 《The American journal of gastroenterology》1998,93(1):115-117
A 62-year-old man was admitted to our hospital because of severe jaundice and fever. Physical examination demonstrated hepatosplenomegaly. The laboratory data revealed elevated serum bilirubin, alkaline phosphatase, lactate dehydrogenase, aspartate aminotransferase and alanine aminotransferase, and the reduced hepaplastin test (Normotest). Computed tomography showed hepatosplenomegaly and swelling of the paraaortic lymph nodes. Although he was treated with antibiotics and steroids, he died of hepatic failure 22 days after admission. At autopsy, his liver weighed 1910 grams, and a histological examination of the liver revealed marked infiltration of CD30 (Ki-1) positive lymphoma cells. He was diagnosed as having non-Hodgkin lymphoma, large cell anaplastic type, Ki-1 lymphoma. We herein report our findings of this very rare case of Ki-1 lymphoma associated with hepatic failure. 相似文献
978.
979.
Qi Jiang Eiichi Azuma Masahiro Hirayama Shotaro Iwamoto Tadashi Kumamoto Michihiro Kobayashi Hatsumi Yamamoto Minoru Sakurai Yoshihiro Komada 《Pediatrics international》2001,43(4):334-339
BACKGROUND: Monocytes as antigen-presenting cells play an important role in host defense and transplantation. However, there are little reports on cord blood monocytes, and the role of monocytes in cord blood transplantation is largely unknown. METHODS AND RESULTS: There are several cytokines affecting monocyte function. These include interferon-gamma, interleukin-4, interleukin-10, granulocyte macrophage-colony stimulating factor and hepatocyte growth factor (HGF). We investigated the effect of these cytokines on antigen-presenting capacity (APC) of cord and adult blood monocytes. Using either mononuclear cells or purified CD4+ T cells as responder cells, HGF enhanced APC of adult monocytes most effectively among these cytokines. In contrast, cord blood monocytes failed to respond to HGF. As HLA, costimulatory and adhesion molecules may affect APC function, we examined these antigens of monocytes following HGF stimulation. The HGF upregulated integrin alpha5 subunit (CD49e) and intercellular adhesion molecule-1 (CD54) was expressed in adult blood monocytes, but not in cord blood. In kinetic studies, HGF downregulated c-met protein/HGF receptor expression of adult monocytes in lower concentrations and at shorter incubation time as compared with that of cord blood. CONCLUSIONS: The results suggest that impaired response of cord blood monocytes to HGF may be responsible, in large part, for their functional immaturity. 相似文献
980.
Akiko Ishibashi Riko Ogata Shotaro Sakisaka Ryukichi Kumashiro Yuriko Koga Keiichi Mitsuyama Ryoko Kuromatsu Yasuyo Uchimura Hiroyasu Ijyuin Kumi Tanaka Tadashi Iwao Kunihide Ishii Michio Sata Yoshiko Inoue Yasuko Kin Kotaro Oizumi Hidemi Nishida Tsutomu Imaizumi Kyuichi Tanikawa 《Journal of gastroenterology》1999,34(3):405-409
A 33-year-old woman with a history of photosensitivity, persistent abdominal pain, and liver dysfunction was admitted to
our department because of abdominal pain and progression of liver dysfunction. On admission, levels of protoporphyrin and
coproporphyrin within erythrocytes were markedly increased. Autofluorescent erythrocytes were also detected, leading to a
diagnosis of erythropoietic protoporphyria. A liver biopsy specimen revealed cirrhosis with dark brown granules filling hepatocytes,
bile canaliculi, and bile ductules. Transfusion of washed erythrocytes, hemodialysis, and administration of cholestyramine
and beta-carotene transiently improved levels of porphyrins and liver function. The patient died of rupture of esophageal
varices followed by multiple organ failure. However, the treatments were believed to have extended survival.
Received: September 9, 1998/Accepted: December 18, 1998 相似文献