全文获取类型
收费全文 | 1345篇 |
免费 | 86篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 7篇 |
儿科学 | 30篇 |
妇产科学 | 36篇 |
基础医学 | 233篇 |
口腔科学 | 55篇 |
临床医学 | 101篇 |
内科学 | 332篇 |
皮肤病学 | 80篇 |
神经病学 | 118篇 |
特种医学 | 40篇 |
外科学 | 74篇 |
综合类 | 11篇 |
预防医学 | 90篇 |
眼科学 | 25篇 |
药学 | 92篇 |
中国医学 | 2篇 |
肿瘤学 | 109篇 |
出版年
2024年 | 2篇 |
2023年 | 18篇 |
2022年 | 27篇 |
2021年 | 58篇 |
2020年 | 31篇 |
2019年 | 29篇 |
2018年 | 50篇 |
2017年 | 34篇 |
2016年 | 52篇 |
2015年 | 36篇 |
2014年 | 58篇 |
2013年 | 64篇 |
2012年 | 123篇 |
2011年 | 123篇 |
2010年 | 64篇 |
2009年 | 49篇 |
2008年 | 71篇 |
2007年 | 101篇 |
2006年 | 84篇 |
2005年 | 79篇 |
2004年 | 76篇 |
2003年 | 60篇 |
2002年 | 52篇 |
2001年 | 4篇 |
2000年 | 10篇 |
1999年 | 8篇 |
1998年 | 13篇 |
1997年 | 7篇 |
1996年 | 9篇 |
1995年 | 6篇 |
1994年 | 10篇 |
1993年 | 7篇 |
1992年 | 1篇 |
1991年 | 2篇 |
1990年 | 3篇 |
1989年 | 1篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1986年 | 1篇 |
1985年 | 2篇 |
1984年 | 1篇 |
1983年 | 2篇 |
1982年 | 2篇 |
1981年 | 2篇 |
1979年 | 1篇 |
排序方式: 共有1435条查询结果,搜索用时 15 毫秒
21.
22.
23.
24.
25.
Iku Kamitani Takeshi Saito Hiroki Yokoyama Aya Nakano Hiroto Ishii Susumu Tanoue Daiki Hattori Sayaka Oshima Shoko Ishii Tadahiro Gunji Ryoko Fukushima Atsushi Katsube Takaki Shimada Kaichi Nishiwaki Nobuaki Dobashi Shingo Yano 《Journal of infection and chemotherapy》2021,27(4):639-641
The FMS-related tyrosine kinase 3 (FLT3) internal tandem duplication mutations (FLT3-ITD) positive acute myeloid leukemia (AML) is a disease with a dismal outcome. Gilteritinib is a second-generation FLT3 inhibitor with activity against ITD and high affinity toward the FLT3 receptor, thereby showing therapeutic potential for relapsed/refractory FLT3-mutated AML. Bone marrow transplantation (BMT) from a human leukocyte antigen (HLA) identical sibling donor was performed in a 38-year-old Japanese male with FLT3-ITD positive AML. Neutrophil engraftment (>0.5 × 109/L) was achieved on day 16, and bone marrow remission was revealed on day 32. The patient's AML relapsed hematologically four months after BMT and was resistant to salvage chemotherapy. Gilteritinib was administered and the patient achieved non-remission but ‘stable disease’ status according to the response criteria. During administration, liver damage was observed but controllable. The patient received cord blood transplantation (CBT) as the second hematopoietic stem cell transplantation (HSCT) three months after relapse and achieved second remission. There was no evidence of recurrence of AML four months after CBT. This case demonstrates that gilteritinib can control FLT3-ITD positive AML that relapsed early after initial HSCT and can bridge to second HSCT. 相似文献
26.
Akihiro Nakamura Yuto Monma Shoko Kajitani Kazuki Noda Sota Nakajima Hideaki Endo Tohru Takahashi Eiji Nozaki 《Heart and vessels》2016,31(9):1446-1455
Both postprandial hyperlipidemia and hyperinsulinemia have been thought to play an important role in the development of atherosclerosis, and to be a potent risk factor for cardiovascular event. To examine effects of glycemic state on postprandial hyperlipidemia and hyperinsulinemia in patients with coronary artery disease (CAD), a total of 112 consecutive male patients with angiographically confirmed CAD were loaded with a high-fat and high-glucose test meal. CAD patients were divided into three groups as “non-diabetic”, “prediabetic”, and “diabetic” CAD groups. The serum triglyceride (TG) and remnant-like particle cholesterol (RLP-C) levels at the 6th hour in diabetic CAD group showed significantly higher than non-diabetic CAD group, and the incremental area under the curves (iAUCs) of these levels in diabetic CAD group were significantly greater than non-diabetic CAD group (TG, P = 0.0194; RLP-C, P = 0.0219). There were no significant differences in the iAUCs of TG or RLP-C between prediabetic and non-diabetic CAD group. The AUCs of plasma insulin levels or insulin resistance index (IRI): (AUCs of insulin) × (AUCs of glucose) as the insulin resistance marker were greater in diabetic CAD group than non-diabetic CAD group (insulin, P = 0.0373; IRI, P = 0.0228). The AUCs of serum TG or RLP-C levels showed a correlation with the AUCs of plasma insulin (AUC-TG, r = 0.5437, P < 0.0001; AUC-RLP-C, r = 0.6847, P < 0.0001), and they correlated well with the insulin resistance index (AUC-TG, r = 0.7724, P < 0.0001; AUC-RLP-C, r = 0.7645, P < 0.0001). We found that the insulin resistance showed a close relationship with postprandial hyperlipidemia in CAD patients. Diabetic, but not prediabetic state, may be a risk for postprandial impaired lipid metabolism in CAD patients. 相似文献
27.
Shoko Mitrrt Yamada Yusuke Tomia Hideki Murakami Makoto Nakane 《Clinical Case Reports》2015,3(7):548-550
Traumatic CSDH enlarged in two cases with VP or LP shunt system although the shunt valve pressure was increased to 200 mmH2O. In surgery, the hematoma cavity pressure was found to be 130 and 140 mmH2O, suggesting that to raise the shunt valve pressure is not effective for decreasing CSDH volume. 相似文献
28.
29.
30.