全文获取类型
收费全文 | 10007篇 |
免费 | 403篇 |
国内免费 | 47篇 |
专业分类
耳鼻咽喉 | 148篇 |
儿科学 | 225篇 |
妇产科学 | 153篇 |
基础医学 | 1132篇 |
口腔科学 | 194篇 |
临床医学 | 554篇 |
内科学 | 2312篇 |
皮肤病学 | 160篇 |
神经病学 | 872篇 |
特种医学 | 221篇 |
外科学 | 1877篇 |
综合类 | 35篇 |
预防医学 | 285篇 |
眼科学 | 304篇 |
药学 | 750篇 |
中国医学 | 20篇 |
肿瘤学 | 1215篇 |
出版年
2023年 | 52篇 |
2022年 | 94篇 |
2021年 | 152篇 |
2020年 | 99篇 |
2019年 | 148篇 |
2018年 | 178篇 |
2017年 | 136篇 |
2016年 | 181篇 |
2015年 | 177篇 |
2014年 | 203篇 |
2013年 | 281篇 |
2012年 | 418篇 |
2011年 | 471篇 |
2010年 | 290篇 |
2009年 | 242篇 |
2008年 | 475篇 |
2007年 | 450篇 |
2006年 | 533篇 |
2005年 | 586篇 |
2004年 | 561篇 |
2003年 | 565篇 |
2002年 | 535篇 |
2001年 | 276篇 |
2000年 | 299篇 |
1999年 | 264篇 |
1998年 | 179篇 |
1997年 | 128篇 |
1996年 | 119篇 |
1995年 | 93篇 |
1994年 | 94篇 |
1993年 | 85篇 |
1992年 | 209篇 |
1991年 | 188篇 |
1990年 | 203篇 |
1989年 | 162篇 |
1988年 | 152篇 |
1987年 | 139篇 |
1986年 | 110篇 |
1985年 | 111篇 |
1984年 | 78篇 |
1983年 | 77篇 |
1982年 | 52篇 |
1979年 | 53篇 |
1978年 | 39篇 |
1977年 | 39篇 |
1975年 | 36篇 |
1972年 | 37篇 |
1971年 | 40篇 |
1969年 | 38篇 |
1968年 | 35篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
991.
Nishi T Hamamoto Y Warita E Yamanaka Y Kitamura T Matsui T Kotake K 《Gan to kagaku ryoho. Cancer & chemotherapy》2011,38(5):831-833
In palliative chemotherapy, a focus on palliative treatment is recommended in cases that are unresponsive to multiple drugs. Careful judgment is needed, however, because when treatment is inadequate, cases that are considered to be unresponsive may include some in which chemotherapy would be effective. We treated a patient with metastatic colon cancer who was judged to be unresponsive to multiple drugs at another hospital, yet repetition of standard therapy proved effective. We report this case as an instructive example of the importance of maintaining dose intensity. The patient was a 60-year-old man. Lung metastasis appeared after he had undergone proctectomy and received adjuvant chemotherapy by his previous doctor. Low-dose intensity IFL therapy, FOLFOX4 therapy (once a month), and FOLFIRI therapy (once only) had been performed, but the patient's condition worsened and he was referred to our hospital. This case could not be considered unresponsive to multiple drugs because the treatment had been insufficient, and so we restarted FOLFIRI treatment with the international standard dose and obtained control of the disease. Treatment was then continued, and the patient died 2 years and 11 months after he was first examined at our hospital. Simple palliative treatment alone should not be given unthinkingly when patients are referred for outpatient palliative care. Full consideration of the dosing and schedule is needed. 相似文献
992.
993.
Okusaka T Furuse J Funakoshi A Ioka T Yamao K Ohkawa S Boku N Komatsu Y Nakamori S Iguchi H Ito T Nakagawa K Nakachi K 《Cancer science》2011,102(2):425-431
Erlotinib combined with gemcitabine has not been evaluated in Japanese patients with unresectable pancreatic cancer. This two-step phase II study assessed the safety and pharmacokinetics of erlotinib 100 mg/day (oral) plus gemcitabine 1000 mg/m(2) (i.v. days 1, 8, 15) in a 28-day cycle in the first step, and efficacy and safety in the second step. The primary end-point was safety. One hundred and seven patients were enrolled (first step, n = 6; second step, n = 101). The most common adverse event was RASH (compiled using the preferred terms rash, acne, exfoliative rash, dermatitis acneiform, erythema, eczema, dermatitis and pustular rash) in 93.4% of patients. One treatment-related death occurred. While interstitial lung disease-like events were reported in nine patients (8.5%; grade 1/2/3, 3.8/2.8/1.9%), all patients recovered or improved. The median overall survival, the 1-year survival rate and median progression-free survival were 9.23 months, 33.0% and 3.48 months, respectively. The overall response and disease control rates were 20.3% and 50.0%, respectively. In Japanese patients with unresectable pancreatic cancer, erlotinib plus gemcitabine had acceptable toxicity and efficacy that was not inferior to that seen in Western patients. 相似文献
994.
995.
996.
Yamanaka K Nakata M Kaneko N Fushiki H Kita A Nakahara T Koutoku H Sasamata M 《International journal of oncology》2011,39(3):569-575
Metastatic triple negative breast cancer [TNBC, with negative expression of estrogen and progesterone receptors and no overexpression of HER2/neu (ErbB-2)] remains a major therapeutic challenge because of its poor overall prognosis and lack of optimal targeted therapies. Survivin has been implicated as an important mediator of breast cancer cell growth and dysfunctions in apoptosis, and its expression correlates with a higher incidence of metastases and patient mortality; thus, survivin is an attractive target for novel anti-cancer agents. In previous studies, we identified YM155 as a small molecule that selectively suppresses survivin expression. YM155 inhibits the growth of a wide range of human cancer cell lines. Tumor regression induced by YM155 is associated with decreased intratumoral survivin expression, increased apoptosis and a decreased mitotic index. In the present study, we evaluated the antitumor efficacy of YM155 both in vitro and in vivo using preclinical TNBC models. We found that YM155 suppressed survivin expression, including that of its splice variants (survivin 2B, δEx3 and 3B), resulting in decreased cellular proliferation and spontaneous apoptosis of human TNBC cells. In a mouse xenograft model, continuous infusion of YM155 led to the complete regression of subcutaneously established tumors. Furthermore, YM155 reduced spontaneous metastases and significantly prolonged the survival of animals bearing established metastatic tumors in the MDA-MB-231-Luc-D3H2-LN orthotopic model. These results suggest that the survivin-suppressing activity of YM155 may offer a novel therapeutic option for patients with metastatic TNBC. 相似文献
997.
Sugahara K Michikawa Y Ishikawa K Shoji Y Iwakawa M Shibahara T Imai T 《International journal of oncology》2011,39(4):761-769
Lymph node metastasis (LNM) in oral squamous cell carcinoma (OSCC) is known to associate with a significant decrease of 5-year survival. Genetic factors related to the difference of the LNM status in the OSCC have been not fully elucidated. Array-based comparative genomic hybridization (CGH) with individual gene-level resolution and real-time quantitative polymerase chain reaction (QPCR) were conducted using primary tumor materials resected from 54 OSCC patients with (n=22) or without (n=32) cervical LNM. Frequent gain was observed at the 11q13 region exclusively in patients with cervical LNM, which was confirmed by real-time QPCR experiments using 11 genes (TPCN2, MYEOV, CCND1, ORAOV1, FGF4, TMEM16A, FADD, PPFIA1, CTTN, SHANK2 and DHCR7) in this region. It was revealed that two distinct amplification cores existed, which were separated by a breakpoint between MYEOV and CCND1 in the 11q13 region. The combination of copy number amplification at CTTN (core 2) and/or TPCN2/MYEOV (core 1), selected from each core, was most significantly associated with cervical LNM (P=0.0035). Two amplification cores at the 11q13 region may have biological impacts on OSCC cells to spread from the primary site to local lymph nodes. Further study of a larger patient series should be conducted to validate these results. 相似文献
998.
Yuko Kijima Heiji Yoshinaka Sumiya Ishigami Munetsugu Hirata Koichi Kaneko Tadao Mizoguchi Akihiro Nakajo Hideo Arima Yawara Funasako Shinichi Ueno Shoji Natsugoe 《Breast cancer (Tokyo, Japan)》2011,18(4):273-281
Background
Oncoplastic techniques, which combine the concepts of oncologic and plastic surgery, are becoming more common, especially in Western countries, however, only a few case reports have been published in Japan. We report the results of oncoplastic surgery for Japanese patients with early breast cancer in the lateral quadrant area.Methods
In eight patients, their breasts were ptotic, and each lesion was diagnosed to be suitable for breast-conservative surgery, we performed oncoplastic surgery combining reduction-type partial mastectomy with nipple–areola recentralization.Results
The total operation period ranged from 112 to 290 min with the mean period being 189 min. For the six patients who received contralateral mirror image reduction surgery and recentralization of the nipple–areola complex, the reconstruction period ranged from 80 to 230 min with the mean period being 102 min. For two patients who underwent oncoplastic surgery to the treated breast only, the reconstruction periods were 40 and 60 min, respectively. The weights of the resected tissue of the treated breast ranged from 60 to 306 g whereas that of the contralateral breast ranged from 70 to 302 g. Postoperative seroma after axillary dissection was observed in one case.Conclusions
Oncoplastic surgery for patients with ptotic breasts was successfully performed and may become more popular in Japan in the near future. 相似文献999.
1000.
Keiko Sato Mariko Naito Hideharu Yukitake Hideki Hirakawa Mikio Shoji Mark J. McBride Ryan G. Rhodes Koji Nakayama 《Proceedings of the National Academy of Sciences of the United States of America》2010,107(1):276-281
Porphyromonas gingivalis secretes strong proteases called gingipains that are implicated in periodontal pathogenesis. Protein secretion systems common to other Gram-negative bacteria are lacking in P. gingivalis, but several proteins, including PorT, have been linked to gingipain secretion. Comparative genome analysis and genetic experiments revealed 11 additional proteins involved in gingipain secretion. Six of these (PorK, PorL, PorM, PorN, PorW, and Sov) were similar in sequence to Flavobacterium johnsoniae gliding motility proteins, and two others (PorX and PorY) were putative two-component system regulatory proteins. Real-time RT-PCR analysis revealed that porK, porL, porM, porN, porP, porT, and sov were down-regulated in P. gingivalis porX and porY mutants. Disruption of the F. johnsoniae porT ortholog resulted in defects in motility, chitinase secretion, and translocation of a gliding motility protein, SprB adhesin, to the cell surface, providing a link between a unique protein translocation system and a motility apparatus in members of the Bacteroidetes phylum. 相似文献