全文获取类型
收费全文 | 2192篇 |
免费 | 123篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 28篇 |
儿科学 | 43篇 |
妇产科学 | 9篇 |
基础医学 | 326篇 |
口腔科学 | 84篇 |
临床医学 | 161篇 |
内科学 | 492篇 |
皮肤病学 | 14篇 |
神经病学 | 116篇 |
特种医学 | 121篇 |
外科学 | 327篇 |
综合类 | 8篇 |
现状与发展 | 1篇 |
预防医学 | 97篇 |
眼科学 | 8篇 |
药学 | 179篇 |
中国医学 | 2篇 |
肿瘤学 | 310篇 |
出版年
2024年 | 6篇 |
2023年 | 30篇 |
2022年 | 65篇 |
2021年 | 91篇 |
2020年 | 47篇 |
2019年 | 68篇 |
2018年 | 66篇 |
2017年 | 52篇 |
2016年 | 82篇 |
2015年 | 94篇 |
2014年 | 81篇 |
2013年 | 77篇 |
2012年 | 121篇 |
2011年 | 168篇 |
2010年 | 84篇 |
2009年 | 70篇 |
2008年 | 114篇 |
2007年 | 109篇 |
2006年 | 121篇 |
2005年 | 123篇 |
2004年 | 105篇 |
2003年 | 123篇 |
2002年 | 118篇 |
2001年 | 22篇 |
2000年 | 24篇 |
1999年 | 24篇 |
1998年 | 21篇 |
1997年 | 13篇 |
1996年 | 13篇 |
1995年 | 9篇 |
1994年 | 13篇 |
1993年 | 14篇 |
1992年 | 10篇 |
1991年 | 10篇 |
1990年 | 10篇 |
1989年 | 11篇 |
1988年 | 9篇 |
1987年 | 15篇 |
1986年 | 11篇 |
1985年 | 9篇 |
1984年 | 8篇 |
1983年 | 9篇 |
1981年 | 8篇 |
1980年 | 9篇 |
1979年 | 5篇 |
1977年 | 3篇 |
1976年 | 4篇 |
1974年 | 5篇 |
1973年 | 4篇 |
1970年 | 5篇 |
排序方式: 共有2326条查询结果,搜索用时 0 毫秒
21.
Takuya Watanabe Masayuki Tanahashi Eriko Suzuki Naoko Yoshii Hiroyuki Tsuchida Shogo Yobita Kensuke Iguchi Suiha Uchiyama Minori Nakamura 《Journal of thoracic disease》2022,14(5):1393
BackgroundSecondary pneumothorax with interstitial lung disease (ILD) is often difficult to treat in comparison to primary pneumothorax. The purpose of this study was to analyze the actual management and outcome, and to find the most effective treatment.MethodsAmong 180 patients with pneumothorax caused by ILD, who were managed between January 2000 and April 2021, 129 patients were included. Fifty-one patients with observation only were excluded. In the present study, a patient was considered to be cured if their chest tube could be removed.ResultsThe managements included chest tube drainage alone (n=41), pleurodesis (n=67), bronchoscopic treatment (n=14), and surgery (include overlapping cases) (n=25). The mean number of pleurodesis treatments was 2.4 (range, 1–9), and the most frequently used agent was blood-patch. All patients who received bronchoscopic treatment underwent bronchial occlusion with silicon spigots. The surgical procedures included bullectomy (n=20), lung cyst ligation (n=3), pleural covering with oxidized cellulose sheet (n=1), and spraying of fibrin glue alone (n=1). One hundred patients (77.5%) were curatively treated, 27 patients (20.9%) died, and 2 patients were transferred without chest tube removal. Among 25 patients who received surgery [including 6 patients with performance status (PS) ≥2], 24 patients (96.0%) were cured, and 1 patient died due to an acute exacerbation of ILD after surgery. The univariate analysis revealed that PS ≥2 and >3 pleurodesis treatments were significant non-curative factors, while steroid treatment before the development of pneumothorax was not.ConclusionsThe outcomes of surgery for pneumothorax in patients with ILD were good, and it is desirable to consider the surgical indications. 相似文献
22.
Koji Yamaguchi M.D. Yoshihide Kato Shogo Maeda Katsutoshi Kitamura 《Journal of gastroenterology》1990,25(4):489-493
A cavernous hemangioma of the stomach in a 41-year-old Japanese man was reported. The patient had numerous hemorrhagic telangiectasias
in the skin and was also diagnosed as having a submucosal tumor of the stomach by an incidental upper gastrointestinal X-ray
study. Wedge resection of the stomach was performed. The tumor was located in the submucosal, proper muscular and subserosal
layers. The resected specimen showed proliferation of vascular spaces lined with a layer of endothelial cells and filled with
red blood cells together with a partially calcified thrombus. The histopathologic diagnosis was cavernous hemangioma of the
stomach with calcified thrombus. The patient has been doing well for twenty years. We report the case and briefly review the
literature.
This study is supported in part by a Grant from Federation of National Public Service and Affiliated Personnel Mutual Aid
Association, Tokyo, Japan. 相似文献
23.
Protein-Losing Enteropathy in Systemic Lupus Erythematosus 总被引:3,自引:0,他引:3
Shojiro Takagi M.D. Kazuo Oshimi M.D. Morito Sumiya M.D. Nobuyuki Gonda M.D. Shogo Kano M.D. Fumimaro Takaku M.D. 《The American journal of gastroenterology》1983,78(3):152-154
Although protein-losing enteropathy can be associated with a variety of disorders, only three cases have been described in association with systemic lupus erythematosus. In the case described herein, protein-losing enteropathy was the only clinical manifestation of systemic lupus erythematosus. Small intestinal biopsy revealed edema and mild mononuclear cell infiltration in lamina propria mucosae and no evidence of lymphangiectasia. X-ray studies of the gastrointestinal tract were normal. Protein-losing enteropathy responded to high-dose corticosteroid therapy. Protein-losing enteropathy should be suspected as a possible cause of unexplained hypoalbuminemia in systemic lupus erythematosus. 相似文献
24.
Park J Banno S Sugiura Y Yoshikawa K Naniwa T Wakita K Hayami Y Sato S Ueda R 《Internal medicine (Tokyo, Japan)》2004,43(4):331-335
There are several case reports of systemic vasculitis associated with chronic suppurative lung diseases. We describe a 46-year-old female, previously diagnosed as having diffuse panbronchiolitis (DPB), presenting with hemosputum and dyspnea. Her serum titer of MPO-ANCA was positive together with a high titer of BPI-ANCA. Chest X-ray and chest CT scan showed pulmonary hemorrhage, and the renal biopsy specimen revealed necrotizing, crescentic glomerulonephritis. She was diagnosed as having ANCA-associated vasculitis, and more specifically, microscopic polyangiitis accompanied by DPB. She was treated with methylprednisolone pulse therapy, followed by intravenous cyclophosphamide. This case suggested a possible association with chronic bacterial infection, which may play a role in the pathogenesis of ANCA-associated vasculitis. 相似文献
25.
26.
Katushiro Mabe Masumi Okuda Shogo Kikuchi Kenji Amagai Rie Yoshimura Mototsugu Kato Naoya Sakamoto Masahiro Asaka 《Journal of infection and chemotherapy》2018,24(7):538-543
Background/Aims
Treating Helicobacter pylori infection in young people is effective for preventing gastric cancer. This study compares the efficacy of triple therapies in adolescents and young adults in Japan.Methods
This multicenter, randomized trial was conducted between February 2012 and March 2015. Infected participants were stratified into adolescents (13–19 years) and young adults (20–39 years). They were randomly assigned to a clarithromycin based (PAC) or metronidazole based (PAM) triple therapy for 1 week.Results
Overall, 137 and 169 participants received the PAC and PAM treatments, respectively. In adolescents, the H. pylori eradication rates were 60.5% and 63.4% for PAC, and 98.3% and 100% for PAM in the intention-to-treat (ITT) and per-protocol (PP) analyses, respectively. In young adults, the eradication rates were 67.0% and 66.7% for PAC, and 95.5% and 96.3% for PAM in ITT and PP analyses, respectively. The eradication rate of PAM was significantly higher than that of PAC in both strata. No severe adverse events were observed.Conclusion
In Japan, PAM may be selected as a first-line treatment for young people with H. pylori if antibiotic susceptibility tests cannot be performed. 相似文献27.
Chronic necrotizing pulmonary aspergillosis in pneumoconiosis: clinical and radiologic findings in 10 patients. 总被引:3,自引:0,他引:3
Takashi Kato Ikuji Usami Hiroki Morita Masahiro Goto Masayoshi Hosoda Atsushi Nakamura Shogo Shima 《Chest》2002,121(1):118-127
STUDY OBJECTIVE: To characterize clinical, radiographic, and CT findings of chronic necrotizing pulmonary aspergillosis (CNPA) in patients with pneumoconiosis. METHODS: We studied 10 patients with pneumoconiosis who were seen at Asahi Rosai Hospital and received a clinical diagnosis of CNPA during a 15-year period, and detailed the long-term clinical and radiologic courses of four cases. RESULTS: All patients were men, ranging in age from 48 to 77 years (mean, 60.1 years). Their occupational histories included pottery making (n = 9) and coal mining (n = 1). Chest radiographic findings by the International Labor Organization profusion grading system were greater than category 2. All patients were symptomatic, with a productive cough, hemoptysis, and dyspnea. Serum findings were positive for the Aspergillus antibody in seven patients. The radiologic findings consisted of parenchymal infiltrates and cavities mostly containing mycetoma, which generally involved the upper lobes. The disease progressed slowly; in one patient, broad destruction of the lung was observed after > 10 years without antifungal administration. Most of the patients experienced clinical and radiologic improvement after receiving antifungal therapy, by oral, inhaled, or intracavitary administration. CONCLUSIONS: Chronic persistent or progressive upper-lobe infiltrates and cavities in patients with pneumoconiosis should raise the possibility of CNPA. Early diagnosis and initiation of effective therapy are recommended to achieve a better outcome. 相似文献
28.
Seiki Kamisue Midori Shima Takuya Nishimura Ichiro Tanaka Hiroaki Nakai Shogo Morichika Noboru Takata Atsushi Kuramoto Akira Yoshioka 《British journal of haematology》1994,86(1):106-111
We have established an ELISA for detecting thrombin cleavage of the FVIII light chain at Arg1689 . The method used a coating alloantibody which recognized amino acid residues 2248–2312 in the C2 domain, together with a second monoclonal antibody, NMC-VIII/10, which recognized residues 1675–1684 in the amino-terminal region of the light chain. FVIII antigen (FVIII:Ag) was measured after treatment of plasma with various concentrations of thrombin. The FVIII:Ag of normal plasma was reduced in a dose-dependent manner by the thrombin, falling to 28% in the presence of 100 U/ml enzyme. The concentration of thrombin that achieved 50% reduction (IC50 ) was approximately 1·0 U/ml. The plasma of four haemophilia A positive (A+ ) and two haemophilia A reduced (AR ) patients were analysed. The IC50 of all patients was more than 1·0 U/ml, indicating that thrombin cleavage of the FVIII light chain was defective. One haemophilia A+ plasma did not respond to thrombin in this ELISA system. The patient (TI) was a haemophiliac with FVIII coagulant activity of 0·04 U/ml and FVIII:Ag of 1·78 U/ml. In addition, immunoblotting of the purified FVIII from TI showed that thrombin cleavage of the 80 kilodalton (kD) light chain was impaired. The patient's DNA was amplified using the polymerase chain reaction with a set of synthetic oligonucleotide primers spanning amino acid residues 1646–1714. Sequence analysis of the amplified DNA fragments revealed a cytosine to thymine transition, converting an arginine 1689 to cysteine. This abnormal FVIII was designated as FVIII Hiroshima. Our ELISA system is a simple and useful method of evaluating the proteolytic cleavage by thrombin at Arg1689 . 相似文献
29.
Ikumi Hori Daisuke Ieda Shogo Ito Seimi Ebe Yuji Nakamura Kei Ohashi Kohei Aoyama Ayako Hattori Minoru Kokubo Shinji Saitoh 《Brain & development》2021,43(4):590-595
IntroductionAminoacyl-tRNA synthetase-interacting multifunctional protein 1 (AIMP1) is a non-catalytic component of the multi-tRNA synthetase complex that catalyzes the ligation of amino acids to their correct tRNAs. Bi-allelic truncating variants in the AIMP1 gene have been associated with hypomyelinating leukodystrophy-3 (HLD3; MIM 260600), which is characterized by hypomyelination, microcephaly, seizures and decreased life expectancy. Although peripheral nerve involvement has been assumed for HLD3, no compelling evidence is available to date.Case reportThe case was a first-born Filipino male. He showed profound developmental delay, failure to thrive, and spasticity in his limbs. At three months of age he developed refractory epilepsy. Serial magnetic resonance imaging (MRIs) showed profound myelination delay and progressive cerebral atrophy. He showed abnormal nerve conduction studies. Genetic testing revealed a homozygous pathogenic variant in the AIMP1 gene (NM_004757.3: c.115C > T: p.Gln39*). The parents were heterozygous for the same variant.ConclusionHere, we report a patient with a homozygous nonsense AIMP1 variant showing peripheral neuropathy as well as HLD3. Our case suggests that AIMP1 plays a pivotal role in the peripheral nerve as well as the central nervous system. 相似文献
30.
Isoshima Daichi Yamashiro Keisuke Matsunaga Kazuyuki Taniguchi Makoto Matsubara Takehiro Tomida Shuta Ota Shinzo Sato Michiyoshi Shimoe Yutaka Kohriyama Tatsuo Arias Zulema Omori Kazuhiro Yamamoto Tadashi Takashiba Shogo 《Odontology / the Society of the Nippon Dental University》2021,109(1):239-249
Odontology - There is no conclusive evidence regarding a causal relationship between periodontitis and atherosclerosis. In this study, we examined the microbiome in the oral cavity and atheromatous... 相似文献