全文获取类型
收费全文 | 143篇 |
免费 | 10篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 15篇 |
儿科学 | 5篇 |
妇产科学 | 1篇 |
基础医学 | 29篇 |
口腔科学 | 8篇 |
临床医学 | 14篇 |
内科学 | 26篇 |
皮肤病学 | 4篇 |
神经病学 | 8篇 |
特种医学 | 5篇 |
外科学 | 15篇 |
预防医学 | 11篇 |
眼科学 | 1篇 |
药学 | 5篇 |
肿瘤学 | 7篇 |
出版年
2021年 | 1篇 |
2020年 | 1篇 |
2019年 | 2篇 |
2018年 | 6篇 |
2016年 | 4篇 |
2014年 | 3篇 |
2013年 | 10篇 |
2012年 | 7篇 |
2011年 | 6篇 |
2010年 | 11篇 |
2009年 | 9篇 |
2008年 | 13篇 |
2007年 | 10篇 |
2006年 | 13篇 |
2005年 | 12篇 |
2004年 | 10篇 |
2003年 | 6篇 |
2002年 | 14篇 |
2000年 | 4篇 |
1997年 | 1篇 |
1995年 | 1篇 |
1993年 | 2篇 |
1992年 | 2篇 |
1991年 | 2篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1979年 | 1篇 |
1972年 | 1篇 |
排序方式: 共有154条查询结果,搜索用时 15 毫秒
11.
12.
13.
Tsuneyuki Yamamoto Minqi Li Zhucheng Liu Ying Guo Tomoka Hasegawa Hideo Masuki Reiko Suzuki Norio Amizuka 《Odontology / the Society of the Nippon Dental University》2010,98(2):102-109
Cementum is mineralized tissue with collagen fibrils as its major organic component, and it can be roughly classified into
acellular and cellular cementum. The latter generally consists of a stack of cellular intrinsic fiber cementum layers, in
which intensely and weakly stained lamellae (each about 2.5 μm thick) alternate in light microscopic observations. It has
been suggested that the alternate lamellar pattern results from periodic changes of the intrinsic fiber arrangement, but owing
to the difficulty of observing the fibril arrangement three dimensionally, details were not understood until recently. The
NaOH-maceration method has been developed to overcome this difficulty. For the past two decades, we have studied the structure
and development of cementum by scanning electron microscopy using NaOH-maceration, as well as by light and transmission electron
microscopy, and have accumulated a significant amount of data with regard to the structure and formation of cementum. In light
of these data, we have arrived at the following conclusions: (1) The alternate lamellar pattern conforms to the twisted plywood
model, in which collagen fibrils rotate regularly in the same direction to form two alternating types of lamellae; one type
consists of transversely and almost transversely cut fibrils and the other consists of longitudinally and almost longitudinally
cut fibrils. (2) The development of the intrinsic fiber arrangement may be controlled by cementoblasts; the cementoblasts
move finger-like processes synchronously and periodically to create alternate changes in the intrinsic fiber arrangement,
and this dynamic sequence results in the alternate lamellar pattern. 相似文献
14.
Catherine Dotchin MD MRCP Olivia Msuya RN John Kissima John Massawe Ali Mhina Addess Moshy Eric Aris Ahmed Jusabani David Whiting PhD Gabriel Masuki MD MPH Richard Walker MD FRCP 《Movement disorders》2008,23(11):1567-1672
The prevalence of Parkinson's disease (PD) varies worldwide from 7 to 450 per 100,000, and appears low in sub‐Saharan Africa (SSA) but few data exist. We conducted a prevalence study of PD in rural Tanzania. A door‐to‐door study was conducted in the Hai district project area (population 161,071), using a screening questionnaire followed by structured history and examination of positive responders. Diagnosis was based on the UK PD Society Brain Bank Criteria. 33 (23 men) cases of PD were detected, with mean age 74 years (range 38–94). One patient died before the prevalence date. 78% were previously undiagnosed and untreated. Mean duration of symptoms was 5 years, and median Hoehn and Yahr stage 3. Crude prevalence rates were 30/100,000 (men), 11/100,000 (women) and 20/100,000 (combined). The direct age‐standardized prevalence rates compared with the UK population were 64/100,000 (men), 20/100,000 (women) and 40/100,000 (combined). These rates are higher than previously reported from SSA, but still lower than the developed world. Many PD patients in SSA may never be diagnosed or treated, with consequent reduction in their life expectancy and quality of life. With the world population ageing PD is predicted to become an increasing problem. © 2007 Movement Disorder Society 相似文献
15.
The role of dual-phase enhanced helical computed tomography in difficult intestinal bleeding 总被引:1,自引:0,他引:1
Yoshikawa K Yamaguti T Nakamura M Hirabayasi K Hazano K Utida M Masuki I 《Journal of clinical gastroenterology》2000,31(1):83-84
We report a case of leiomyoma of the small bowel presenting with massive gastrointestinal (GI) bleeding that was diagnosed using dual-phase enhanced helical computed tomography (CT) in the preoperative period. A 68-year-old man was admitted to our hospital because of recurrent rectal bleeding. Gastroduodenoscopic and total colonoscopic examination results were negative; however, the patient continued to show bloody stool. Dual-phase enhanced helical CT was subsequently performed. CT revealed a hypervascular tumor, with evident extravasation of the contrast medium in the bowel lumen. We were successful in establishing the point of bleeding. Exploratory laparotomy was performed the same day. A solid round extraluminal mass was found at the proximal jejunum. Bleeding was observed over the serosal side of this tumor and segmental resection of the tumorous small intestine was performed. Pathologic examination revealed leiomyoma. Enhanced helical CT proved to be useful in localizing active GI bleeding. 相似文献
16.
17.
Shizue Tani-ichi Akihiro Shimba Keisuke Wagatsuma Hitoshi Miyachi Satsuki Kitano Kumiko Imai Takahiro Hara Koichi Ikuta 《Proceedings of the National Academy of Sciences of the United States of America》2013,110(2):612-617
Interleukin (IL)-7 is a cytokine essential for T lymphocyte development and homeostasis. However, little is known about the roles of IL-7 receptor α-chain (IL-7Rα) in late stages of T-cell development. To address this question, we established IL-7Rα–floxed mice and crossed them with CD4-Cre transgenic mice. Resultant IL-7R conditional knockout (IL-7RcKO) mice exhibited marked reduction in CD8 single positive (SP) T cells, regulatory T cells (Tregs), and natural killer T (NKT) cells in thymus. The proportion and proliferation of both mature CD4SP and CD8SP thymocytes were decreased without affecting Runx expression. In addition, expression of the glucocorticoid-induced TNF receptor was reduced in CD4SP and CD8SP thymocytes, and expression of CD5 was decreased in CD8SP thymocytes. IL-7RcKO mice also showed impaired Treg and NKT cell proliferation and inhibition of NKT cell maturation. Bcl-2 expression was reduced in CD4SP and CD8SP thymocytes but not in Tregs and NKT cells, and introduction of a Bcl-2 transgene rescued frequency and CD5 expression of CD8SP thymocytes. Furthermore, IL-7RcKO mice exhibited greatly increased numbers of B cells and, to a lesser extent, γδ T and dendritic cells in thymus. Overall, this study demonstrates that IL-7Rα differentially controls development and maturation of thymocyte subpopulations in late developmental stages and suggests that IL-7R expression on αβ T cells suppresses development of other cell lineages in thymus. 相似文献
18.
Koji Ogawa Yasuyuki Tokinaga Shizue Iwahashi Kazuhiro Mizumoto Yoshio Hatano 《Journal canadien d'anesthésie》2005,52(8):870-877
PURPOSE: This study was designed to examine regional differences in the vascular injury induced by hydrogen peroxide (H2O2) and to determine its modulation by halothane in canine basilar and mesenteric arteries. METHODS: Rings of canine basilar and mesenteric arteries with intact endothelium were mounted in Krebs bicarbonate solution for isometric tension recording. The relaxation responses to substance P (10(-8) M) and sodium nitroprusside (SNP; 10(-8) to 10(-5) M) were examined before and after exposure to H2O2 (1 mM) for eight minutes in the presence or absence of halothane (2%), to evaluate the effects of oxidative injury on the endothelium-dependent and -independent relaxation. The contractile responses to KCl (30 mM) and prostaglandin (PG) F(2alpha) (3 x 10(-6) M) were also compared in rings with and without exposure to H2O2. RESULTS: After exposure to H2O2 the relaxant responses to substance P were significantly inhibited in basilar arteries (P < 0.01), but not in mesenteric arteries. Exposure to H2O2 also attenuated SNP-induced relaxation in basilar (P < 0.05), but not in mesenteric arteries. The attenuation of the contractile responses to KCl and PGF(2alpha) after H2O2 exposure was observed only in basilar arteries (P < 0.01). Simultaneous exposure to halothane did not affect the attenuation of these relaxant and contractile responses. Scanning electron microscopy revealed that H2O2 resulted in marked disruption of the endothelial layer in basilar arteries, compared to almost no morphological changes in mesenteric arteries. CONCLUSION: These results indicate that the endothelium and vascular smooth muscle of the basilar artery are more susceptible to oxidative stress than those of the mesenteric artery. Halothane, at clinically relevant concentrations, exerts no significant influence on this vascular injury. 相似文献
19.
Otávio Bejzman Piltcher Eduardo Macoto Kosugi Eulalia Sakano Olavo Mion José Ricardo Gurgel Testa Fabrizio Ricci Romano Marco Cesar Jorge Santos Renata Cantisani Di Francesco Edson Ibrahim Mitre Thiago Freire Pinto Bezerra Renato Roithmann Francini Greco Padua Fabiana Cardoso Pereira Valera José Faibes Lubianca Neto Leonardo Conrado Barbosa Sá Shirley Shizue Nagata Pignatari Melissa Ameloti Gomes Avelino Juliana Alves de Souza Caixeta Edwin Tamashiro 《Revista brasileira de otorrinolaringologia (English ed.)》2018,84(3):265-279
20.
Shizue Kato Sachiko Itoh Motoyuki Yuasa Toshiaki Baba Chihiro Miyashita Seiko Sasaki Sonomi Nakajima Akiko Uno Hiroyuki Nakazawa Yusuke Iwasaki Emiko Okada Reiko Kishi 《Environmental health and preventive medicine》2016,21(5):334-344