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991.
Zhan P Suo LJ Qian Q Shen XK Qiu LX Yu LK Song Y 《European journal of cancer (Oxford, England : 1990)》2011,47(5):742-747
Chlamydia pneumoniae (C. pneumoniae) is a common cause of acute respiratory infection and has been hypothesised to cause several chronic diseases, including lung cancer. Numbers studies were conducted to analyse the association between C. pneumoniae infection and risk of lung cancer, but no clear consensus had been found. To assess this relationship more precisely, a meta-analysis was performed. The electronic databases PubMed, Embase, Web of Science and CNKI were searched; Data were extracted and analysed independently by two investigators. Ultimately, 12 studies, involving 2595 lung cancer cases and 2585 controls from four prospective studies and eight retrospective studies were included. Overall, people exposed to C. pneumoniae infection had an odds ratio (OR) of 1.48 (95% confidence interval (CI), 1.32-1.67) for lung cancer risk, relative to those not exposed. C. pneumoniae infection was clearly identified as a risk factor for lung cancer in both prospective studies (OR, 1.16; 95% CI, 1.00-1.36) and retrospective studies (OR, 2.17; 95% CI, 1.79-2.63) and in both IgA ? 16 cutoff group (OR, 1.22; 95% CI, 1.06-1.41) and the IgA ? 64 cutoff group (OR, 2.35; 95% CI, 1.88-2.93). In conclusion, C. pneumoniae infection is associated with an increased risk for lung cancer, higher titre may be a better predictor of lung cancer risk. 相似文献
992.
Xiaobing Chen Xinguang Cao Wenjie Dong Suxia Luo Zhenhe Suo Yinchun Jin 《Digestive diseases and sciences》2010,55(8):2219-2226
Purpose
Human TIP30 was initially identified as a candidate metastasis suppressor gene whose expression was down-regulated in human liver, lung, breast, and prostate cancers, and recently the role of this gene was examined in colorectal cancer. The aim of this study was to determine the level of TIP30 expression in colorectal carcinoma (CRC). 相似文献993.
Background
The copper-containing intrauterine devices (Cu-IUDs) are being increasingly used worldwide as an effective contraception for family planning. To avoid abnormal bleeding, pain, partial and complete expulsion, which are associated with the burst release of cupric ions during the first few days, a novel cross-linked composite based on polyvinyl alcohol (PVA) that contained cupric ions, but not metallic copper, was developed by our research team.Study Design
As a logical extension of our previous work, the corrosion products and release behavior of this composite after immersing in simulated body fluid (SBF) for 1 year were studied by X-ray fluorescence spectroscopy (XRF), X-ray diffraction (XRD) and atomic absorption spectrophotometry (AAS).Results
No other new elements, such as P, Cl and Ca, appeared on the surface of the composite, and no Cu2O was formed after immersing in SBF for 1 year, indicating that the effectiveness of copper can be greatly improved. Furthermore, no significant change on time dependence was found for the release rates of cupric ions in the composite compared with that of metallic copper, suggesting the absent burst release of cupric ions in the composite.Conclusion
The present in vitro long-term data suggest that this novel copper-containing composite has potential as a substitute for conventional materials used in the manufacture of IUDs. 相似文献994.
目的 探讨缬沙坦对肝硬化患者血清TGF-B1、CG和HA浓度的影响作用.方法 36例肝硬化患者随机分为两组:对照组(n=18)和治疗组(n=18).对照组给予常规保肝治疗,治疗组在此基础上加用缬沙坦80 mg/d,疗程为1个月.治疗前后采用酶联免疫吸附测定法(ELISA)检测血清TGF-Bl浓度,放射免疫法检测血清CG和HA的浓度.结果 治疗组经缬沙坦治疗后血清TGF.61、CG和HA水平均显著降低(P<0.05);对照组常规治疗后血清TGF一61、CG和HA浓度也有所降低,但差异无统计学意义(P>0.05);两组治疗前后差值比较,差异有统计学意义(P<0.05).结论 缬沙坦可能通过降低血清TGF.61、CG和HA的水平改善肝硬化患者的肝纤维化程度. 相似文献
995.
目的 探讨缬沙坦对肝硬化门静脉高压症患者(PHT)ET、NO、TNF-α浓度的影响.方法 36例肝硬化门静脉高压症患者,随机分为两组:对照组和治疗组,每组各18例.对照组给予常规保肝治疗,治疗组在此基础上加用缬沙坦80 mg/d,疗程为1个月.治疗前后采用放射免疫法检测血浆ET、血清TNF-α浓度,硝酸还原酶法检测血清NO浓度.结果 治疗组在加用缬沙坦后,ET、NO、TNF-α均较治疗前明显降低(P<0.05).对照组治疗后ET、NO、TNF-α也有所降低,但差异无统计学意义(P>0.05).两组治疗前后差值比较,差异有统计学意义(P<0.05). 结论 缬沙坦可能通过改变血管活性物质的浓度降低肝硬化门静脉压力. 相似文献
996.
997.
998.
The objective of this study was to retrospectively investigate the surgical indications, operation methods, and postoperative
results of patients with cavernous malformations (CMs) and the use of neuronavigation. Seventy patients with CMs were operated
on in our hospital. The initial symptoms were hemorrhage in 31 cases, seizures in 29 cases, focal neurological deficit in
4 cases, and headache in 5 cases. Only one asymptomatic case was incidentally identified by radiological examination. The
size of CMs ranged from 5 to 50 mm (mean: 21 mm). The CMs in 39 patients were located within the white matter of the hemispheres,
11 within the basal ganglia or thalamus, 5 within the cerebellum, and 6 in multiple locations. Prior to the operation, five
fiducial markers were placed on the scalp and magnetic resonance imaging (MRI) was performed. Data were transferred to the
neuronavigation workstation, a profile of tumors was drawn up, and a three-dimensional reconstruction was completed. The foci
were separated and resected under a microscope through a sulci and fissures approach. All the lesions were resected totally.
No residual foci were found by postoperative computed tomography (CT)/MRI examination, and there was no operative death. The
disability rate was 8.6%; four patients had a new transitory neurological deficit within 1 month after the operation, and
one patient with thalamic CMs developed facial paralysis. All patients, however, recovered in 6 months. Twenty-four patients
with preoperative epilepsy were followed up for 6–24 months (mean: 19.4 months). After the operation, seizures disappeared
in 19 patients and symptoms improved in 5. CMs can be determined in patients even if patients are asymptomatic. Surgical treatment
should be considered if bleeding occurs. An operation with the guidance of neuronavigation is safe and can decrease the occurrence
of disability following the procedure. 相似文献
999.
1000.
K-19 mRNA RT-PCR in detecting micrometastasis in regional lymph nodes of gastric cancer 总被引:1,自引:0,他引:1
AIM: To investigate the value and prospect of RT-PCR in detecting micrometastasis in regional lymph nodes of gastric cancer. METHODS: Histopathology was used and K19 mRNA expression was detected by RT-PCR in tumor tissues and lymph nodes from gastric cancer patients undergoing radical resection of gastric carcinoma. RESULTS: K19 mRNA was expressed in all tumor specimens of 30 cases; of the 126 lymph nodes, 26 were histopathologically positive (20.6%), and 42 positive (33.3%) by RT-PCR. Amplification fragments of 460 and 540 bp were shown in all the tumor tissues and metastatic lymph nodes after K19 andβ-actin RT-PCR, while only a 540 bp fragment appeared in the lymph nodes of non-tumor patients. CONCLUSION: K19 mRNA RT-PCR is sensitive and specific in testing micrometastasis in regional lymph nodes of gastric cancer, and it is superior to routine histopathology. 相似文献