284名饭店打工妹抑郁现状及其影响因素研究

目的了解饭店打工妹抑郁现状,探讨其与社会资本和社会网络的关系。方法本研究为横断面调查。选取合肥市12家饭店、蚌埠市14家饭店为研究现场,以在饭店打工、农村户口、16～24岁、未婚女性为研究对象。采用流调中心用抑郁量表（CES-D）对其抑郁症状进行评定。抑郁评分≥20分界定为有抑郁症状;采用自编问卷评估社会资本和社会网络。结果调查对象平均年龄20.18岁,抑郁症状检出率为46.5%。多因素Logistic回归分析结果显示,打工妹年龄平均每增加3岁,抑郁症状发生的危险性降低到0.609倍;单亲或父母再婚家庭是抑郁症状发生的危险因素（OR=2.542）;认知社会资本为中下等、中上等及上等者发生抑郁症状的危险性较下等者均降低（OR=0.483、0.511、0.254）。结论饭店打工妹抑郁症状检出率高,尤其是年龄小、来自单亲或父母再婚家庭者。完善社会保障制度,增强社会诚信氛围、加大社会支持力度,可提高认知社会资本,降低抑郁症状发生的危险性。     

直肠前突与出口梗阻性便秘的关系

目的探讨直肠前突与功能性出口梗阻性便秘的关系及临床意义。方法回顾性分析417例功能性出口梗阻性便秘患者的临床和动态排粪造影资料。对直肠前突病例的力排过程进行动态回放,并分析其表现。结果①310例有直肠前突。392例有直肠内脱垂,353例有会阴下降,69例有盆底痉挛或耻直肌肥厚。95．20％（397／417）的病例至少存在两种异常,无单发直肠前突病例。男女患者间比较,直肠前突、会阴下降、盆底痉挛或耻直肌肥厚的发生率差异均有统计学意义（P〈0．01）,但直肠内脱垂的发生率差异无统计学意义（P〉0．05）。②直肠前突病例力排过程动态回放：直肠内钡剂排空或接近排空、直肠远端增粗粘膜堆积226例,占72．90％;直肠内钡剂不排或呈滴状排出、远端粘膜脱入肛管和（或）盆底痉挛或耻直肌肥厚71例,占22．90％;前突囊袋缩小不明显、囊袋后方直肠内脱垂13例,占4．20％。结论直肠前突不是引起便秘的主要原因,明确直肠前突与功能性出口梗阻性便秘的关系对临床制定治疗方案有指导意义。     

缬沙坦对肝硬化患者血HA、CG及PAI 1的影响

目的 探讨缬沙坦对肝硬化患者血HA、CG及PAI-1的影响.方法 将36例肝硬化患者随机分为治疗组和对照组各18例.对照组给予常规治疗,治疗组在此基础上口服缬沙坦80 mg/d,疗程1个月.治疗前后采血,用放射免疫法检测血清HA、CG的水平,酶联免疫法测定血浆PAI-1的水平.结果 治疗组患者HA、CG及PAI-1的水平较治疗前下降.对照组上述指标的下降无统计学意义.结论 缬沙坦能够降低肝硬化患者血HA、CG及PAI-1的水平,从而具有一定抗肝纤维化的作用.     

硝普钠与硝酸甘油治疗急性左心衰的疗效观察

目的：观察硝普钠与硝酸甘油治疗急性左心衰的疗效和安全性。方法：294例急性左心衰患者随机分成硝普钠治疗组158例、硝酸甘油治疗组136例,对照观察静脉给药后5天两组NYHA分级心功能改善程度。结果：两组治疗右心功能改善程度差异显著。结论：微泵注射硝普钠治疗急性左心衰起效快、疗效好、不良反应少、安全可靠。     

Feasibility Studies of Nebulized SARS-CoV-2 Neutralizing Antibody in Mice and Cynomolgus Monkeys

Pharmaceutical Research - Neutralizing antibodies, administrated through intravenous infusion, have shown to be highly efficacious in treating mild and moderate COVID-19 caused by SARS-CoV-2...     

Trends in operating room-based glaucoma procedures at a single eye center from 2016–2020

AIM: To evaluate trends in glaucoma procedures at the Peking University Eye Center in 2016–2020. METHODS: A retrospective search of all glaucoma procedures performed at our institution were performed. Data were analyzed by calculating the absolute numbers and relative weightage of each procedure per year. RESULTS: The average age of glaucoma patients undergoing surgical procedures was 62.33±17.87y, and 55% were women. From 2016 to 2019, the number of surgical procedures performed in glaucoma patients showed an overall upward trend from 749 to 1460, although it decreased slightly in 2020 (n=1393), probably due to the COVID-19 pandemic. The number of trabeculectomies did not change significantly in 2016 (n=161) to 2018 (n=164) but decreased in 2019 (n=139) to 2020 (n=121), indicating a reduction in its relative weightage among glaucoma procedures (from 21.50% to 8.69%). The number of glaucoma drainage device implantations and minimally invasive glaucoma surgeries both increased (50 and 58 respectively in 2019), except in 2020. The number of transscleral cyclophotocoagulation procedures was relatively stable, increasing until 2017 (n=218) and then decreasing. Cataract surgeries with or without glaucoma procedures accounted for a large number of the total surgeries, increasing from 247 (32.97%) in 2016 to 967 (69.42%), among which cataract extraction combined with goniosynechialysis was the most frequent. CONCLUSION: The overall increase in the number of operating room-based surgical procedures is significant. Trabeculectomy is one of the most commonly performed procedures, despite the relative decline in its weightage. Other procedures, including use of glaucoma drainage devices and mini shunts and minimally invasive glaucoma surgeries, are gaining greater acceptance. Notably, lens-related surgery plays an important role in glaucoma management.     

Study on mechanical performance of the cerebral aneurysm clip]

Blood vessel tissue mechanical performance and cerebral aneurysm clip mechanical property are investigated. Results show that physical character of cerebral aneurysm clip, such as pressure value, maximum opening width of the blade tip, width, thickness and material is very important for its medical purpose. Surveying instrument is devised successfully.     

肩锁关节脱位27例疗效分析

目的：评价Ⅲ型肩锁关节脱位三种手术方法的疗效，为临床治疗选择提供依据。方法：对1989年1月至2003年1月间27例Ⅲ型肩锁关节脱位患者采用单纯克氏针固定12例，克氏针钢丝张力带固定8例，改良Dewar手术7例。结果：27例全部获得随访，随访时间3个月～72个月，平均24个月，参照Karlssou^[1]术后疗效评价标准，优良率分别为：单纯克氏针固定16．67％，克氏针钢丝张力带固定62．5％，改良Dewar，手术85．8％。结论：采用改良Dewar手术方法优于其他内固定方法，值得临床推广应用。     

长春新碱诱导人脑胶质瘤细胞的耐药性

本文报告以细胞周期特异化疗药长春新碱（ＶＣＲ）对人脑胶质瘤Ｕ２５１ＭＧ细胞进行体外分步诱导法造成细胞的耐药性。细胞集落实验表明，经ＶＣＲ诱导的胶质瘤细胞Ｕ２５１ＶＲ—４０在１０～４０ｎｇ／ｍＬＶＣＲ培养液中，其细胞形成相当率是未诱导组Ｕ２５１ＭＧ细胞的２～１３倍（Ｐ＜０．０１）。同时，耐ＶＣＲ的Ｕ２５１ＶＲ—４Ｑ细胞对阿霉素（ＡＤＭ）亦有交叉耐药性，但与卡氮芥（ＢＣＮＵ）无耐药性产生。另外，５ｕｇ／ｍＬ尼卡地平（ＮＣＤＰ）能使其反转成药敏细胞。诱导过程中还发现，Ｕ２５１ＭＧ胶质瘤细胞直接在高浓度ＶＣＲ（６０ｎｇ／ｍＬ培养液中被杀伤和发生明显形态变化后，仍有少数细胞在无化疗药培养环境７～１０天可以复苏并且再增殖。研究结果不仅表明ＶＣＲ诱导的胶质瘤细胞能够产生多药耐受性（ＭＤＲ），而且提示该胶质瘤细胞中可能还存在一种修复微管系统的抗药机理。     

Molecular modeling of μ opioid receptor and receptor-ligand interaction

目的：构建μ阿片受体（μＯＲ）的三维结构模型并研究它与芬太尼衍生物的相互作用．方法：以细菌视紫红质为模板，模拟μＯＲ的三维结构；然后，将芬太尼衍生物对接到μＯＲ的七个α螺旋束之内，并计算结合能．结果：（１）得到受体－配基作用模型．（２）模型中，基本结合位点可能是Ａｓｐ１４７和Ｈｉｓ２９７．Ａｓｐ１４７与配基的正电性铵基形成强的静电和氢键相互作用，这种作用在Ｈｉｓ２９７和配基的羰基Ｏ原子之间较弱．受体、配基间还存在某些π－π相互作用．（３）受体配基结合能与芬太尼衍生物的镇痛活性间有良好的相关性．结论：模型有助于理解受体配基的相互作用和设计新的阿片μ选择性配基．