全文获取类型
收费全文 | 43756篇 |
免费 | 2132篇 |
国内免费 | 218篇 |
专业分类
耳鼻咽喉 | 344篇 |
儿科学 | 802篇 |
妇产科学 | 675篇 |
基础医学 | 5441篇 |
口腔科学 | 1122篇 |
临床医学 | 2955篇 |
内科学 | 10971篇 |
皮肤病学 | 674篇 |
神经病学 | 3024篇 |
特种医学 | 1597篇 |
外科学 | 8252篇 |
综合类 | 202篇 |
预防医学 | 1435篇 |
眼科学 | 485篇 |
药学 | 3138篇 |
中国医学 | 143篇 |
肿瘤学 | 4846篇 |
出版年
2023年 | 245篇 |
2022年 | 475篇 |
2021年 | 871篇 |
2020年 | 484篇 |
2019年 | 651篇 |
2018年 | 824篇 |
2017年 | 642篇 |
2016年 | 745篇 |
2015年 | 831篇 |
2014年 | 1108篇 |
2013年 | 1267篇 |
2012年 | 2023篇 |
2011年 | 2156篇 |
2010年 | 1225篇 |
2009年 | 982篇 |
2008年 | 1838篇 |
2007年 | 1942篇 |
2006年 | 1950篇 |
2005年 | 1983篇 |
2004年 | 1988篇 |
2003年 | 1904篇 |
2002年 | 1882篇 |
2001年 | 1704篇 |
2000年 | 1650篇 |
1999年 | 1586篇 |
1998年 | 587篇 |
1997年 | 483篇 |
1996年 | 420篇 |
1995年 | 375篇 |
1994年 | 371篇 |
1993年 | 313篇 |
1992年 | 1006篇 |
1991年 | 943篇 |
1990年 | 827篇 |
1989年 | 917篇 |
1988年 | 785篇 |
1987年 | 710篇 |
1986年 | 747篇 |
1985年 | 685篇 |
1984年 | 439篇 |
1983年 | 380篇 |
1982年 | 193篇 |
1981年 | 192篇 |
1979年 | 310篇 |
1978年 | 243篇 |
1977年 | 211篇 |
1975年 | 214篇 |
1974年 | 190篇 |
1973年 | 177篇 |
1971年 | 180篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
51.
M Fukuoka T Tanimoto Y Zhou N Kawasaki A Tanaka I Ikemoto T Machida 《Journal of applied toxicology : JAT》1989,9(4):277-283
Repeated oral doses of di-n-butyl phthalate (DBP) to male rats caused a decrease in testicular fructose and glucose and a sloughing of the germ cells on the first day of treatment. On day 2, more severe sloughing was seen and was accompanied by decreases in testicular iron and zinc levels and increases in the level of inositol and cholesterols. The sloughing was followed by atrophy, accompanied by dissociation of the germ cells from the Sertoli cells and reduction of triglycerides, cholesterols and phospholipids containing choline and ethanolamine residues in the testis. 相似文献
52.
S Tanaka 《Nihon rinsho. Japanese journal of clinical medicine》1987,45(10):2285-2291
53.
Kazuta Fukumori Yoichi Yano Koutaro Kuwaki Shuji Sumie Eiji Ando Masatoshi Tanaka Michio Sata 《Nihon Shokakibyo Gakkai zasshi》2007,104(8):1225-1230
A 64-year-old man was admitted for further examinations of a liver tumor. The patient was diagnosed as chronic hepatitis C complicated with advanced hepatocelluar carcinoma (HCC) with left portal vein tumor thrombosis. As he refused surgical treatment, hepatic arterial infusion chemotherapy (HAIC) using cisplatin and 5-fluorouracil was performed initially. Administration of ursodesoxycholic acid (UDCA) was also started. Following HAIC, microwave coagulation therapy for residual tumor was added. Consequently, viable lesions of HCC disappeared completely. At present, after more than 8 years, neither signs of tumor recurrence, nor elevation of hepatic enzymes has been observed. Although the precise reason for long survival of this patient is not known, we speculate that suppression of levels of hepatic enzymes, as well as HAIC for subclinical intrahepatic metastasis, contributed to the good outcome. Therapeutic strategy for hepatic inflammation seems to be important for long-term prevention of hepatocarcinogenesis. 相似文献
54.
Shiro Oka Shinji Tanaka Iwao Kaneko Hiroyuki Kanao Kazuaki Chayama 《Digestive endoscopy》2007,19(Z1):S30-S33
Endoscopic submucosal dissection (ESD) for colorectal tumors is steadily being developed. Safety and standardization of ESD for colorectal tumors have not been yet established because of the technical difficulties and the unsuitable anatomical characteristics of the colon and rectum. The authors mainly use a Flex knife for mucosal incision and a Hook knife for submucosal dissection to perform ESD safely. Skillful colonoscopic control, selection of scope, distal attachment tip hood, adequate high‐frequency generator and correct approach strategy should all be considered for safe performance of ESD. However, the incidence of indicative lesions is rare because the majority of colorectal tumors are adenomatous large laterally spreading tumors, which can be cured by intentional endoscopic piecemeal resection. At present, ESD for colorectal tumors should be performed only at central facilities that have expert colonoscopists. With the development of new devices and associated techniques, technical standardization of ESD for colorectal tumors is expected in the near future. 相似文献
55.
Yoshihiro Kokubo Hitonobu Tomoike Chihiro Tanaka Mariko Banno Tomohiko Okuda Nozomu Inamoto Kei Kamide Yuhei Kawano Toshiyuki Miyata 《Hypertension research》2006,29(8):611-619
We previously selected a group of hypertension candidate genes by a key word search using the OMIM database of NCBI and validated 525 coding single nucleotide polymorphisms (SNPs) in 179 hypertension candidate genes by DNA sequencing in a Japanese population. In the present study, we examined the association between 61 non-synonymous SNPs and blood pressure variations and hypertension. We used DNA samples taken from 1,880 subjects in the Suita study, a population-based study using randomly selected subjects. Analyses of covariance adjusting for age, body mass index, hyperlipidemia, diabetes, smoking, drinking, and antihypertensive medication revealed that 17 polymorphisms in 16 genes (APOB, CAST, CLCNKB, CTNS, GHR, GYS1, HF1, IKBKAP, KCNJ11, LIPC, LPL, P2RY2, PON2, SLC4A1, TRH, VWF) were significantly associated with blood pressure variations. Multivariate logistic regression analysis with adjustment for the same factors revealed that 11 polymorphisms in 11 genes (CAST, CTLA4, F5, GC, GHR, LIPC, PLA2G7, SLC4A1, SLCI8A1, TRH, VWF) showed significant associations with hypertension. Five polymorphisms in five genes, CAST(calpastatin), LIPC (hepatic lipase), SLC4A1 (band 3 anion transporter), TRH (thyrotropin-releasing hormone), and VWF (von Willebrand factor), were significantly associated with both blood pressure variation and hypertension. Thus, our study suggests that these five genes were susceptibility genes for essential hypertension in this Japanese population. 相似文献
56.
57.
58.
Kazuo Yamakawa Masashi Takanashi Masao Watanabe Noriyuki Nakamura Tomonori Kobayashi Masato Hasegawa Yoshikuni Mizuno Shigeki Tanaka Hideo Mori 《Neuropathology》2006,26(6):586-591
We report on a male patient with Pick disease who had shown severe white matter atrophy and dilatation of the lateral ventricle in the frontal lobe from an early stage. Upon admission to our hospital 2 years after disease onset, the patient showed apathy, and MRI revealed severe atrophy of the cortex and white matter of the frontal lobe. He died at age 74, 11 years after disease onset. Autopsy revealed severe atrophy of the frontal and temporal lobes, severe loss of white matter in the frontal lobe, dilatation of the lateral ventricles, and cortical thinning. Histopathological examination showed severe loss of myelinated fibers in the frontal white matter and severe neuronal loss with gliosis in the frontal and temporal cortices. Many Pick bodies were seen. Our patient had a rare case of Pick disease predominantly affecting the frontal lobe with severe involvement of the white matter from an early stage. This case suggests that myelinated fibers in the white matter as well as cerebral neurons are primarily affected in Pick disease. 相似文献
59.
Takahisa Tateishi Kimihiro Tanaka Yoshikiyo Ito Kunihiko Mitsuo 《Clinical neurology》2006,46(4):254-260
We reported a case of X-linked lymphoproliferative syndrome (XLP) with multiple nodular lesions in the brain and lungs. A 21-year-old man was admitted because of one month history of low grade fever, headache, nausea, and amnesia. He developed agammaglobulinemia following Epstein-Barr virus infection at 3-year-old, and thereafter was administered 7.5g of immunoglobulin every 3 weeks with a diagnosis of XLP. Physical examination was unremarkable on admission. Neurological examination revealed disorientation of time, and bilateral gaze-evoked nystagmus. Neuropsychological tests demonstrated impairment of recent memory and calculation. Pleocytosis (83/microl) and increase of protein (1269 mg/dl) and IgG (141 mg/dl) in the CSF were observed. Brain MRI showed multiple nodular lesions with high intense signal on T2-weighted images and Gd-DTPA enhancement on T1-weighted images. Chest CT showed multiple nodular lesions in the bilateral lungs. The needle lung biopsy was performed, which showed infiltration of lymphocytes around the vessels. An immunohistochemical study showed that the infiltrating cells were mainly CD8 positive T lymphocytes. B lymphocyte and plasma cells were not seen. The histological findings excluded intravascular malignant lymphoma and lymphomatoid granulomatosis. Therefore we diagnosed lymphoid vasculitis. The patient developed pancytopenia caused by hemophagocytic syndrome 48 days after admission and was treated with 1 g of methylprednisolone per day for 3 days and a tapered dose of steroid (500 mg to 125 mg of methylprednisolone and 60 mg to 10mg of predonisolone) for 21 days, which resulted in the improvement of clinical features (hemophagocytic syndrome and central nervous system symptoms) and the abnormal CSF findings. The multple nodular lesions in the brain and the lungs shrank 1 month after treatment and disappeared 11 months later. There are few reports concerning lymphoid vasculitis with XLP, and no effective treatment has been described. Our case suggests that steroid therapy may be useful for the treatment of lymphoid vasculitis in XLP. 相似文献
60.
The effectiveness of various oxygen carrying treatments in sensitizing subpopulations of the FSallC fibrosarcoma to low doses of radiation was assessed, and compared with survivals obtained with the same cells after in vivo irradiation under normally oxygenated or hypoxic conditions. FSallC tumors were treated with 2-10 Gray then the Hoechst 33342 dye diffusion method was used to separate the tumor into bright (enriched in normally oxygenated cells) and dim (enriched in hypoxic cells) subpopulations. There was good agreement between the survival of normally oxygenated cells in culture and bright cells from tumors and between hypoxic cells in culture and dim cells from tumors over a radiation dosage range of 2-5 Gray. At 10 Gray bright cells from tumors were minimally less sensitive to the radiation dose than normally oxygenated cells in vivo. When maximally effective doses of perfluorochemical emulsions (F44E at 4 g PFC/kg or Fluosol-DA at 2.4 g PFC/kg) or a purified bovine hemoglobin solution (PBHS at 1.32 g protein/kg) were administered 1 hr. prior to radiation therapy with carbogen (95% O2, 5% CO2) breathing prior to and during radiation delivery, low single doses of x-ray (2-5 Gray) were measurably more cytotoxic toward both FSallC tumor cell subpopulations. These results indicate that perfluorochemical emulsions or purified bovine hemoglobin preparations along with carbogen breathing may be able to increase tumor radiosensitivity to the relatively low radiation doses per fraction used in the clinic. 相似文献