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71.
Cystometric evaluation of recovery in hypocompliant defunctionalized bladder as a result of long‐term dialysis after kidney transplantation 下载免费PDF全文
72.
Antibody‐mediated rejection after ABO‐incompatible pediatric living donor liver transplantation for propionic acidemia: A case report 下载免费PDF全文
Masaki Honda Seisuke Sakamoto Rieko Sakamoto Shirou Matsumoto Tomoaki Irie Koushi Uchida Keita Shimata Seiichi Kawabata Kaori Isono Shintaro Hayashida Hidekazu Yamamoto Fumio Endo Yukihiro Inomata 《Pediatric transplantation》2016,20(6):840-845
We herein present the case of a four‐yr‐old boy with PA who developed AMR after ABO‐incompatible LDLT despite undergoing B cell desensitization using rituximab. Although the CD19+ lymphocyte count decreased to 0.1% nine days after the administration of rituximab, he developed a high fever which was accompanied by arthralgia due to a streptococcal infection 13 days after rituximab prophylaxis. After the clearance of the infection, he underwent ABO‐incompatible LDLT 36 days after the administration of rituximab. The CD19+ lymphocyte count just prior to LDLT was 1.2%. He developed AMR five days after LDLT, and the antidonor‐type IgM and IgG antibody titers increased to 1:1024 and 1:1024, respectively. He was treated by plasma exchange, IVIG, steroid pulse therapy, and rituximab re‐administration; however, his liver dysfunction continued. Despite intensive treatment, he died due to complicated abdominal hernia, acute renal failure, and ARDS. This case suggests that a streptococcal infection may induce the activation of innate immune responses; thus, additional desensitization therapy should be considered prior to ABO‐incompatible LDLT if B cell reactivation is suspected. 相似文献
73.
Haruki Fujisawa Yoshihisa Sugimura Hiroshi Takagi Hiroyuki Mizoguchi Hideyuki Takeuchi Hisakazu Izumida Kohtaro Nakashima Hiroshi Ochiai Seiji Takeuchi Atsushi Kiyota Kazuya Fukumoto Shintaro Iwama Yoshiko Takagishi Yoshitaka Hayashi Hiroshi Arima Yukio Komatsu Yoshiharu Murata Yutaka Oiso 《Journal of the American Society of Nephrology : JASN》2016,27(3):766-780
Hyponatremia is the most common clinical electrolyte disorder. Once thought to be asymptomatic in response to adaptation by the brain, recent evidence suggests that chronic hyponatremia may be linked to attention deficits, gait disturbances, risk of falls, and cognitive impairments. Such neurologic defects are associated with a reduction in quality of life and may be a significant cause of mortality. However, because underlying diseases such as adrenal insufficiency, heart failure, liver cirrhosis, and cancer may also affect brain function, the contribution of hyponatremia alone to neurologic manifestations and the underlying mechanisms remain unclear. Using a syndrome of inappropriate secretion of antidiuretic hormone rat model, we show here that sustained reduction of serum sodium ion concentration induced gait disturbances; facilitated the extinction of a contextual fear memory; caused cognitive impairment in a novel object recognition test; and impaired long-term potentiation at hippocampal CA3–CA1 synapses. In vivo microdialysis revealed an elevated extracellular glutamate concentration in the hippocampus of chronically hyponatremic rats. A sustained low extracellular sodium ion concentration also decreased glutamate uptake by primary astrocyte cultures, suggesting an underlying mechanism of impaired long-term potentiation. Furthermore, gait and memory performances of corrected hyponatremic rats were equivalent to those of control rats. Thus, these results suggest chronic hyponatremia in humans may cause gait disturbance and cognitive impairment, but these abnormalities are reversible and careful correction of this condition may improve quality of life and reduce mortality. 相似文献
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Akihito Endo Fuko Sasaki Shintaro Maeno Yu Kanesaki Yu Hamaguchi Glaezel Angelique Torres 《International journal of food sciences and nutrition》2018,69(7):857-869
Soymilk contains several functional nutrients and is thus a promising ingredient for production of functional foods. The present research aimed to study starter properties, functional characteristics and safety of Lactobacillus paraplantarum D2-1, a promising starter culture for soymilk fermentation. Strain D2-1 actively fermented soymilk within 24?h but had weak activity of additional acid production after 7 d. Succinate and acetoin, which could be linked to flavour and taste, were accumulated in fermented soymilk. In vitro study revealed that the organism has several beneficial properties, including high survival ability in artificial gastric juice, high abilities of mucus adhesion and biofilm formation and production of γ-aminobutyric acid and conjugated linoleic acid, without any significant risks for consumption. Genome sequencing supported the desirable metabolic properties of the strain. These results indicate that L. paraplantarum D2-1 is a suitable starter for soymilk fermentation and is a promising probiotic candidate that can be used safely. 相似文献
76.
Shingo Hatakeyama Shintaro Narita Masahiro Takahashi Toshihiko Sakurai Sadafumi Kawamura Senji Hoshi Masanori Ishida Toshiaki Kawaguchi Shigeto Ishidoya Jiro Shimoda Hiromi Sato Itsuto Hamano Teppei Okamoto Koji Mitsuzuka Akihiro Ito Norihiko Tsuchiya Yoichi Arai Tomonori Habuchi Chikara Ohyama 《International journal of urology》2020,27(7):610-617
77.
Shirahama Shintaro Kaburaki Toshikatsu Takada Sachiko Nakahara Hisae Tanaka Rie Komae Keiko Fujino Yujiro Kawashima Hidetoshi Aihara Makoto 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2020,258(3):639-645
Graefe's Archive for Clinical and Experimental Ophthalmology - To clarify the prevalence of secondary glaucoma (SG) and its speed of progression in patients with herpes simplex virus... 相似文献
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Kosuke Endo Taku Iida Shintaro Yagi Atsushi Yoshizawa Yasuhiro Fujimoto Kohei Ogawa Yasuhiro Ogura Akira Mori Toshimi Kaido Shinji Uemoto 《Surgery today》2014,44(12):2293-2299