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S. R. Wilson S. Shinde I. Appleby M. Boscoe D. Conway C. Dryden K. Ferguson W. Gedroyc S. M. Kinsella M. H. Nathanson J. Thorne M. White E. Wright 《Anaesthesia》2019,74(5):638-650
There has been an increase in the number of units providing anaesthesia for magnetic resonance imaging and the strength of magnetic resonance scanners, as well as the number of interventions and operations performed within the magnetic resonance environment. More devices and implants are now magnetic resonance imaging conditional, allowing scans to be undertaken in patients for whom this was previously not possible. There has also been a revision in terminology relating to magnetic resonance safety of devices. These guidelines have been put together by organisations who are involved in the pathways for patients needing magnetic resonance imaging. They reinforce the safety aspects of providing anaesthesia in the magnetic resonance environment, from the multidisciplinary decision making process, the seniority of anaesthetist accompanying the patient, to training in the recognition of hazards of anaesthesia in the magnetic resonance environment. For many anaesthetists this is an unfamiliar site to give anaesthesia, often in a remote site. Hospitals should develop and audit governance procedures to ensure that anaesthetists of all grades are competent to deliver anaesthesia safely in this area. 相似文献
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Rao RN Maurya PK Shinde DD Khalid S 《Journal of pharmaceutical and biomedical analysis》2011,55(2):282-287
Alzheimer disease (AD) is characterized pathologically by extracellular amyloid deposits composed of amyloid β (Aβ) protein. A simple and rapid method using HPLC with fluorescence detector was developed and validated for determination of tramiprosate in rat plasma. Pre-column derivatization of the deproteinized rat plasma was carried out using o-phthaldialdehyde (OPA) as a fluorescent reagent in presence of 3-mercaptopropionic acid. The liquid chromatographic separation was achieved on a Kromasil C18 column using methanol:acetonitrile: 20 mM phosphate buffer pH 7.5 (8.0:17.5:74.5 v/v/v) as a mobile phase in an isocratic elution mode. The eluents were monitored by a fluorescence detector set at 330 and 450 nm of excitation and emission wavelength respectively. Vigabatrin was used as an internal standard. The method was linear within the range 30.0-1000.0 ng/mL. Design of experiments (DOE) was used to evaluate the robustness of the method. The developed method was applied to study the pharmacokinetics of tramiprosate in rats. 相似文献
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Andrew G. Hadd Jeff Houghton Ashish Choudhary Sachin Sah Liangjing Chen Adam C. Marko Tiffany Sanford Kalyan Buddavarapu Julie Krosting Lana Garmire Dennis Wylie Rupali Shinde Sylvie Beaudenon Erik K. Alexander Elizabeth Mambo Alex T. Adai Gary J. Latham 《The Journal of molecular diagnostics : JMD》2013,15(2):234-247
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Duffey MO Vos TJ Adams R Alley J Anthony J Barrett C Bharathan I Bowman D Bump NJ Chau R Cullis C Driscoll DL Elder A Forsyth N Frazer J Guo J Guo L Hyer ML Janowick D Kulkarni B Lai SJ Lasky K Li G Li J Liao D Little J Peng B Qian MG Reynolds DJ Rezaei M Scott MP Sells TB Shinde V Shi QJ Sintchak MD Soucy F Sprott KT Stroud SG Nestor M Visiers I Weatherhead G Ye Y D'Amore N 《Journal of medicinal chemistry》2012,55(1):197-208
This article describes the discovery of a series of potent inhibitors of Polo-like kinase 1 (PLK1). Optimization of this benzolactam-derived chemical series produced an orally bioavailable inhibitor of PLK1 (12c, MLN0905). In vivo pharmacokinetic-pharmacodynamic experiments demonstrated prolonged mitotic arrest after oral administration of 12c to tumor bearing nude mice. A subsequent efficacy study in nude mice achieved tumor growth inhibition or regression in a human colon tumor (HT29) xenograft model. 相似文献