全文获取类型
收费全文 | 3655篇 |
免费 | 238篇 |
国内免费 | 27篇 |
专业分类
耳鼻咽喉 | 43篇 |
儿科学 | 96篇 |
妇产科学 | 137篇 |
基础医学 | 390篇 |
口腔科学 | 96篇 |
临床医学 | 299篇 |
内科学 | 768篇 |
皮肤病学 | 109篇 |
神经病学 | 140篇 |
特种医学 | 191篇 |
外国民族医学 | 1篇 |
外科学 | 737篇 |
综合类 | 76篇 |
一般理论 | 1篇 |
预防医学 | 222篇 |
眼科学 | 79篇 |
药学 | 290篇 |
中国医学 | 32篇 |
肿瘤学 | 213篇 |
出版年
2023年 | 48篇 |
2022年 | 110篇 |
2021年 | 169篇 |
2020年 | 124篇 |
2019年 | 148篇 |
2018年 | 220篇 |
2017年 | 145篇 |
2016年 | 128篇 |
2015年 | 128篇 |
2014年 | 160篇 |
2013年 | 209篇 |
2012年 | 261篇 |
2011年 | 258篇 |
2010年 | 159篇 |
2009年 | 151篇 |
2008年 | 185篇 |
2007年 | 188篇 |
2006年 | 184篇 |
2005年 | 169篇 |
2004年 | 136篇 |
2003年 | 102篇 |
2002年 | 105篇 |
2001年 | 39篇 |
2000年 | 35篇 |
1999年 | 20篇 |
1998年 | 13篇 |
1997年 | 12篇 |
1996年 | 21篇 |
1995年 | 19篇 |
1994年 | 10篇 |
1993年 | 16篇 |
1992年 | 18篇 |
1991年 | 23篇 |
1990年 | 25篇 |
1989年 | 13篇 |
1988年 | 17篇 |
1987年 | 19篇 |
1986年 | 12篇 |
1985年 | 8篇 |
1984年 | 8篇 |
1983年 | 8篇 |
1981年 | 10篇 |
1980年 | 9篇 |
1979年 | 6篇 |
1976年 | 7篇 |
1974年 | 5篇 |
1969年 | 6篇 |
1967年 | 6篇 |
1966年 | 5篇 |
1965年 | 4篇 |
排序方式: 共有3920条查询结果,搜索用时 15 毫秒
11.
12.
Defining epithelial cell progenitors in the human oxyntic mucosa 总被引:7,自引:0,他引:7
In the human stomach, the oxyntic epithelium includes numerous tubular invaginations consisting of short pits opening into long glands. The pit is lined by pit cells, whereas the gland is composed of three regions: the base, containing zymogenic cells; the neck, containing neck cells; and the isthmus, composed of little known immature cells and of parietal cells, which are also scattered through the neck and base. The aim of this study was to examine the ultrastructure of the immature cells and to determine their relation to mature cells. To do so, normal oxyntic mucosal biopsies from subjects ranging from 20-43 years old were fixed in aldehydes and postfixed in reduced osmium for electron microscopy and morphometric analysis. The immature cells were sorted out into four classes, whose roles were clarified by comparison with the thoroughly investigated mouse oxyntic epithelium. The first class was composed of the least differentiated immature cells, which were rare and characterized by minute, dense, or cored secretory granules and were accordingly named mini-granule cells. Their function was not clarified. The second class consisted of pre-pit cells, which were characterized by few dense mucous granules and give rise to pit cells that ascend the pit wall and, after reaching the luminal surface, die or are extruded. Both pre-pit and pit cells underwent continuous renewal and, therefore, together constituted a renewal system referred to as pit cell lineage. The third class, or pre-neck cells, characterized by cored secretory granules, give rise to neck cells that descend toward the base region and differentiate further into pre-zymogenic cells, which finally become zymogenic cells. The latter eventually degenerate and die. Thus pre-neck cells and their progeny constitute a renewing system, designated zymogenic cell lineage. The fourth class, or pre-parietal cells, characterized by long microvilli and few tubulovesicles, differentiate into parietal cells that descend along the neck and base regions and eventually degenerate and die. Pre-parietal and parietal cells represent a renewing system referred to as parietal cell lineage. While the origin of the last three classes of progenitor cells has not been elucidated, it is likely that they arise either from an unidentified multipotential stem cell, possibly the mini-granule cell itself, or from the mitotic activity of pre-pit and pre-neck cells. In conclusion, the human oxyntic epithelium is composed of continually renewing cells organized in distinct cell lineages. 相似文献
13.
The aim of this study was to examine the effect of age on left ventricular (LV) systolic function in normal healthy adults. Eighty consecutive subjects without cardiovascular disease underwent standard and tissue Doppler (TD) echocardiographic imaging. LV systolic function was assessed by load-dependent indices as ejection fraction (EF) and myocardial systolic velocities by TD as well as by the load-independent index, systolic isovolumic acceleration rate (IVA). None of the echocardiographic measurements of systolic function declined with age (mean IVA for the group, 286 +/- 123 cm s(-2); IVA vs. age, r = 0.21, P = 0.1). Likewise, LV end diastolic dimension, wall thickness, mass and left atrial maximum volume were not significantly related to age. On the other hand, as previously reported, echocardiographic indices of diastolic function showed a significant decline with age (P < 0.05). When the group was stratified by gender, isovolumic velocity and acceleration were higher in men than women, but the differences were not significant (P = 0.12 and 0.37, respectively). No significant relation was observed between age and measurements of LV systolic function by regression analysis in women (P > 0.1). However, in men, a positive correlation was noted between average IVA and age (r = 0.63, P = 0.007). In conclusion, age is not associated with a change in cardiac structure and LV systolic function, but is accompanied by a decline in echocardiographic indices of diastolic function. With respect to gender, age does not appear to influence LV systolic function in women, but is associated with an increase in IVA and septal systolic ejection in men. 相似文献
14.
Dalia O. Mohamed Mona M. Sayed Islam F. Abdelkawi Mahmoud H. Elshoieby Salah M. Khallaf Lamia M. Khallaf Doaa M. Fouad 《Current Urology》2021,15(1):11
Background:Randomizing patients to bladder preservation or radical cystectomy (RC) for the treatment of bladder cancer has not been practical, due to patient and physician preferences. Therefore, continually comparing the 2 treatment modalities is needed, in order to make the proper choice for each patient.Patients and methods:The records of T1–4N0M0 bladder cancer patients, who presented to the South Egypt Cancer Institute between 2007 and 2017 and were treated by either bladder preservation or RC were reviewed.Results:Out of the 166 included patients, 81 (48.8%) patients were treated by bladder preservation and 85 (51.2%) patients had RC. For the patients treated by bladder preservation and the patients treated by RC, the 5-year overall survival (OS) was 56% and 60% (p = 0.67), the 5-year local recurrence-free survival was 69% and 73% (p = 0.69), and the 5-year disease-free survival was 45% and 53% (p = 0.16), respectively. After propensity matching analysis, the mean 5-year OS was 58% for the bladder preservation patients and 61% for the RC patients (p = 0.51). It is notable that among the bladder preservation group, 8 patients (10%) had squamous cell carcinoma (SCC) pathology and refused RC. Their OS was 56% compared to 53% for the SCC patients treated by RC (p = 0.6).Conclusion:Bladder preservation is a safe alternative to cystectomy in transitional cell carcinoma stages T1–4aN0M0, and its use in SCC bladder cancer should be further studied, as it could be feasible to spare them from initial cystectomy. 相似文献
15.
16.
Alphonse G Taghian Rita Abi-Raad Sherif I Assaad Adrian Casty Marek Ancukiewicz Eren Yeh Peryhan Molokhia Khaled Attia Timothy Sullivan Irene Kuter Yves Boucher Simon N Powell 《Journal of clinical oncology》2005,23(9):1951-1961
PURPOSE: It has been hypothesized that tumors with high interstitial fluid pressure (IFP) and/or hypoxia respond poorly to chemotherapy (CT) because of poor drug delivery. Preclinical studies have shown that paclitaxel reduces the IFP and improves the oxygenation (pO(2)) of tumors. Our aim is to evaluate the IFP and pO(2) before and after neoadjuvant CT using sequential paclitaxel and doxorubicin in patients with breast cancer tumors of >/= 3 cm. PATIENTS AND METHODS: Patients were randomly assigned, according to an institutional review board-approved phase II protocol, to receive neoadjuvant sequential CT consisting of either four cycles of dose-dense doxorubicin at 60 mg/m(2) every 2 weeks followed by nine cycles of weekly paclitaxel at 80 mg/m(2) (group 1) or vice versa, with paclitaxel administered before doxorubicin (group 2). Patients were re-evaluated clinically and radiologically. The IFP (wick-in-needle technique) and pO(2) (Eppendorf) were measured in tumors at baseline and after completing the administration of the first and second drug. RESULTS: IFP and pO(2) were measured in 54 patients at baseline and after the first CT. Twenty-nine and 25 patients were randomly assigned to groups 1 and 2, respectively. Paclitaxel, when administered first, decreased the mean IFP by 36% (P = .02) and improved the tumor pO(2) by almost 100% (P = .003). In contrast, doxorubicin did not have a significant effect on either parameter. This difference was independent of the tumor size or response measured by ultrasound. CONCLUSION: Paclitaxel significantly decreased the IFP and increased the pO(2), whereas doxorubicin did not cause any significant changes. Tumor physiology could potentially be used to optimize the sequence of neoadjuvant CT in breast cancer. 相似文献
17.
Jamal M. Arif Mohammed Kunhi Yunus M. Siddiqui Khalid A. El Sayed Khaled Y. Orabi Amal Al-Hazzani Mohammed N. Al-Ahdal Fahad M. Al-Khodairy 《Medicinal chemistry research》2004,13(6-7):553-562
In the present study, two of the probable an umor marine compounds, manzamine A and sarcophine, were screened using benzo[a]pyrene (BP)-derived DNA adduct formation in MCF-7 cells as intermediary biomarker. Briefly, MCF-7 cells were treated with
the compounds for 24 h followed by treatment with BP (0.5 μM). After 24h incubation, cellular DNA was isolated and analyzed
for BP-derived DNA adducts by 32P-postlabeling technique. Manzamine A and sarcophine increased the BP-DNA adducts by 2 to 4-folds. Further, manzamine A (50
μM) substantially down regulated the expression of p53 while sarcophine (50 μM) slightly induced the level of p21. The residual
DNA repair ability was almost completely abolished by manzamine A while sarcophine was ineffective. Based on our preliminary
results, these compounds may be classified as potential genotoxic. 相似文献
18.
Meijie Tian Adam T. Cheuk Jun S. Wei Abdalla Abdelmaksoud Hsien-Chao Chou David Milewski Michael C. Kelly Young K. Song Christopher M. Dower Nan Li Haiying Qin Yong Yean Kim Jerry T. Wu Xinyu Wen Mehdi Benzaoui Katherine E. Masih Xiaolin Wu Zhongmei Zhang Sherif Badr Naomi Taylor Brad St. Croix Mitchell Ho Javed Khan 《The Journal of clinical investigation》2022,132(16)
19.
Nehal Elkhoshkhany Samir Marzouk Mohammed El-Sherbiny Heba Ibrahim Bozena Burtan-Gwizdala Mohammed S. Alqahtani Khalid I. Hussien Manuela Reben El Sayed Yousef 《Materials》2022,15(15)
A novel series of glass, consisting of B2O3, Bi2O3, TeO2, and TiO2 (BBTT) containing rare earth oxide RE2O3, where RE is La, Ce, Sm, Er, and Yb, was prepared. We investigated the structural, optical, and gamma attenuation properties of the resultant glass. The optical energy bands, the linear refractive indices, the molar refractions, the metallization criteria, and the optical basicity were all determined for the prepared glass. Furthermore, physical parameters such as the density, the molar volume, the oxygen molar volume, and the oxygen packing density of the prepared glass, were computed. Both the values of density and optical energy of the prepared glass increased in the order of La2O3, Ce2O3, Sm2O3, Er2O3, and then Yb2O3. In addition, the glass doped with Yb2O3 had the lowest refractive index, electronic polarizability, and optical basicity values compared with the other prepared glass. The structures of the prepared glass were investigated by the deconvolution of infrared spectroscopy, which determined that TeO4, TeO3, BO4, BO3, BiO6, and TiO4 units had formed. Furthermore, the structural changes in glass are related to the ratio of the intensity of TeO4/TeO3, depending on the type of rare earth. It is also clarified that the resultant glass samples are good attenuators against low-energy radiation, especially those that modified by Yb2O3, which exhibited superior shielding efficiency at energies of 622, 1170, and 1330 keV. The optical and gamma ray spectroscopy results of the prepared glass show that it is a good candidate for nonlinear optical fibers, laser solid material, and optical shielding protection. 相似文献
20.
Ibrahim M.A. Hassanin Ahmed T. Abdel-Hafeez Sherif A. El-Nashar 《International journal of gynaecology and obstetrics》2008,103(3):222-226