全文获取类型
收费全文 | 1067篇 |
免费 | 55篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 31篇 |
儿科学 | 102篇 |
妇产科学 | 9篇 |
基础医学 | 126篇 |
口腔科学 | 47篇 |
临床医学 | 50篇 |
内科学 | 201篇 |
皮肤病学 | 22篇 |
神经病学 | 52篇 |
特种医学 | 30篇 |
外科学 | 178篇 |
综合类 | 32篇 |
预防医学 | 32篇 |
眼科学 | 36篇 |
药学 | 80篇 |
中国医学 | 2篇 |
肿瘤学 | 94篇 |
出版年
2023年 | 8篇 |
2022年 | 11篇 |
2021年 | 38篇 |
2020年 | 11篇 |
2019年 | 26篇 |
2018年 | 34篇 |
2017年 | 22篇 |
2016年 | 24篇 |
2015年 | 21篇 |
2014年 | 28篇 |
2013年 | 42篇 |
2012年 | 64篇 |
2011年 | 106篇 |
2010年 | 42篇 |
2009年 | 27篇 |
2008年 | 66篇 |
2007年 | 61篇 |
2006年 | 51篇 |
2005年 | 42篇 |
2004年 | 44篇 |
2003年 | 45篇 |
2002年 | 46篇 |
2001年 | 30篇 |
2000年 | 30篇 |
1999年 | 32篇 |
1998年 | 8篇 |
1997年 | 11篇 |
1996年 | 4篇 |
1995年 | 4篇 |
1993年 | 6篇 |
1992年 | 16篇 |
1991年 | 12篇 |
1990年 | 7篇 |
1989年 | 6篇 |
1988年 | 9篇 |
1987年 | 16篇 |
1986年 | 11篇 |
1985年 | 9篇 |
1984年 | 5篇 |
1983年 | 3篇 |
1982年 | 5篇 |
1981年 | 4篇 |
1980年 | 2篇 |
1979年 | 8篇 |
1978年 | 6篇 |
1977年 | 3篇 |
1974年 | 2篇 |
1973年 | 3篇 |
1972年 | 2篇 |
1971年 | 4篇 |
排序方式: 共有1124条查询结果,搜索用时 15 毫秒
111.
Le RQ Melenhorst JJ Battiwalla M Hill B Memon S Savani BN Shenoy A Hensel NF Koklanaris EK Keyvanfar K Hakim FT Douek DC Barrett AJ 《Blood》2011,117(19):5250-5256
After allogeneic stem cell transplantation (SCT), T lymphocyte function is reestablished from the donor's postthymic T cells and through thymic T-cell neogenesis. The immune repertoire and its relation to that of the donor have not been characterized in detail in long-term adult SCT survivors. We studied 21 healthy patients in their second decade after a myeloablative SCT for hematologic malignancy (median follow-up, 12 years). Immune profiles were compared with donor samples cryopreserved at transplant and beyond 10 years from SCT. Only one recipient was on continuing immunosuppression. Compared with the donor at transplant, there was no significant difference in CD4, CD8, natural killer, and B-cell blood counts. However, compared with donors, recipients had significantly fewer naive T cells, lower T-cell receptor excision circle levels, fewer CD4 central memory cells, more effector CD8(+) cells, and more regulatory T cells. TCR repertoire analysis showed no significant difference in complexity of TCRVβ spectratype between recipients and donors, although spectratype profiles had diverged with both gain and loss of donor repertoire peaks in the recipient. In conclusion, long-term allogeneic SCT survivors have subtle defects in their immune profile consistent with defective thymic function but compatible with normal health. This study is registered at http://www.clinicaltrials.gov as NCT00106925. 相似文献
112.
Primary cutaneous mucormycosis is uncommon and is extremely rare in immunocompetent young individuals. Here we report a case of necrotising fasciitis due to mucormycosis in an immunocompetent young individual following minor trauma. Mucormycosis must be suspected in any wound that is worsening despite appropriate treatment even in immunocompetent individuals. 相似文献
113.
Vishnu Prasad Shenoy Shashidhar Vishwanath Bairy Indira G. Rodrigues 《The Brazilian journal of infectious diseases》2010,14(4):372-373
Infections with Entamoeba histolytica are seen worldwide and are more prevalent in the tropics. About 90% of infections are asymptomatic, and the remaining 10% produce a spectrum of clinical syndromes, ranging from dysentery to abscesses of the liver or other organs. Extra-intestinal infection by E. histolytica most often involves liver. Pleuro-pulmonary involvement, seen as the second most common extra-intestinal pattern of infection, is frequently associated with amebic liver abscess. Pulmonary amebiasis occurs in about 2-3% of patients with invasive amebiasis. We report herein the case of a 45-year-old male presenting with hepato-pulmonary amebiasis. The diagnosis was established from direct examination of sputum, in which trophozoites of E. histolytica were detected, and by serology. Following treatment with metronidazole and chloroquine, the clinical evolution improved significantly. On regular follow-up visits, the patient was asymptomatic. This case report reiterates the need for collaboration between clinicians and microbiologists for timely diagnosis of such infections. 相似文献
114.
K. Gowrinath Rahul Magazine Indira Bairy Kiran Chawla Vishnuprasad Shenoy 《Respiratory Medicine CME》2010,3(4):276-278
A rare association of tuberculous liver abscesses with bilateral transudative pleural effusion, ascites and venous thromboembolism in a 22-year-male is reported. While the BACTEC culture and polymerase chain reaction of the aspirate from liver abscess were positive for mycobacterium tuberculosis, all the reports of pleural fluid and ascitic fluid were negative. The bilateral pleural effusion and the ascites may be due to a non-tuberculous cause like hypoalbuminaemia. The finding of venous thromboembolism was incidental. 相似文献
115.
Shobna J. Bhatia D. Nageshwar Reddy Uday C. Ghoshal V. Jayanthi Philip Abraham Gourdas Choudhuri S. L. Broor Vineet Ahuja Philip Augustine V. Balakrishnan D. K. Bhasin Naresh Bhat Ashok Chacko Sunil Dadhich G. K. Dhali Pankaj S. Dhawan Manisha Dwivedi Mahesh K. Goenka Abraham Koshy Ajay Kumar Sri Prakash Misra Shrikant Mukewar E. PedaVeer Raju K. T. Shenoy S. P. Singh Ajit Sood R. Srinivasan 《Indian journal of gastroenterology》2011,30(3):118-127
Background
Gastroesophageal reflux disease (GERD) and its complications are thought to be infrequent in India; there are no data from India on the prevalence of and risk factors for GERD. The Indian Society of Gastroenterology formed a task force aiming to study: (a) the frequency and profile of GERD in India, (b) factors including diet associated with GERD.Methods
In this prospective, multi-center (12 centers) study, data were obtained using a questionnaire from 3224 subjects regarding the frequency, severity and duration of heartburn, regurgitation and other symptoms of GERD. Data were also obtained regarding their dietary habits, addictions, and lifestyle, and whether any of these were related or had been altered because of symptoms. Data were analyzed using univariate and multivariate methods.Results
Two hundred and forty-five (7.6%) of 3224 subjects had heartburn and/or regurgitation at least once a week. On univariate analysis, older age (OR 1.012; 95% CI 1.003–1.021), consumption of non-vegetarian and fried foods, aerated drinks, tea/coffee were associated with GERD. Frequency of smoking was similar among subjects with or without GERD. Body mass index (BMI) was similar in subjects with and without GERD. On multivariate analysis, consumption of non-vegetarian food was independently associated with GERD symptoms. Overlap with symptoms of irritable bowel syndrome was not uncommon; 21% reported difficulty in passage of stool and 9% had mucus in stools. About 25% of patients had consulted a doctor previously for their gastrointestinal symptoms.Conclusion
7.6% of Indian subjects have significant GERD symptoms. Consumption of non-vegetarian foods was an independent predictor of GERD. BMI was comparable among subjects with or without GERD. 相似文献116.
Pradeep Kumar Shenoy Chandrasekhara Nambiar Veettil Jayachandran Liza Rajasekhar Joe Thomas Gumdal Narsimulu 《Modern rheumatology / the Japan Rheumatism Association》2009,19(4):407-415
The aim of this study was to analyze sleep complaints in patients with systemic lupus erythematosus (SLE) and to determine
its prevalence and associations. Fifty outpatients with SLE and an equal number of age- and sex-matched controls were included
in the study. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) in both cases and controls. Depressed
mood, functional disability and pain severity were assessed in patients using standardized questionnaires. Disease severity,
cumulative damage and presence of fibromyalgia were determined by clinical examination. Bivariate associations between sleep
quality and disease-related variables as well as demographic variables were calculated. A series of hierarchical regression
analyses were computed to determine the independent determinant of sleep quality. PSQI scores were significantly higher in
patients with SLE. Prevalence of sleep disturbance was 62%. Functional disability, disease activity and depressed mood correlated
positively with sleep disturbances. 36% of the patients satisfied ACR criteria for fibromyalgia. In multiple regression analyses
disease activity was found to be an independent determinant of sleep quality. The prevalence of poor sleep quality in patients
with SLE was higher than it is generally perceived to be. Functional disability, disease activity and depressed mood contributed
significantly to sleep disturbances in SLE. 相似文献
117.
MacConmara MP Vachharajani N Wellen JR Anderson CD Lowell JA Shenoy S Chapman WC Doyle MB 《HPB : the official journal of the International Hepato Pancreato Biliary Association》2012,14(1):42-48
Background
The inclusion of hepatitis B core antibody-positive (HBcAb+) liver donors is a strategy utilized to increase organ availability. This study examined HBcAb+ transplantation practices to identify specific factors influencing outcomes.Methods
Twenty-five HBcAb+ liver transplants were identified retrospectively among 868 adult transplants performed between 1 January 1997 and 31 December 2009. Twelve (48%) recipients had hepatitis C and five (20%) had hepatitis B. Patient and donor demographics, preoperative morbidity, transplant data and outcomes were examined. Statistical analysis was completed using Student''s t-test or the Kaplan–Meier method. A P-value of <0.05 was considered significant.Results
There was no difference in age, body mass index or comorbidities between HBcAb+ liver recipients and control subjects. Model for End-stage Liver Disease (MELD) scores of >30 were significantly more frequent in HBcAb+ liver recipients (32% vs. 15%; P = 0.04). All patients received immunoglobulin and longterm antiviral therapy as prophylaxis against graft hepatitis B resurgence. No patients who received HBcAb+ livers developed hepatitis B infection on follow-up. Overall survival at 30 days, 1 year and 5 years in HBcAb+ liver recipients was 92%, 74% and 74%, respectively, compared with 96%, 89% and 76%, respectively, in the control group (P = not significant, log-rank test). All except one of the deaths in the HBcAb+ liver recipient group occurred within 90 days postoperatively and in patients with MELD scores >30.Conclusions
The practice of transplanting HBcAb+ grafts incurs low risk for infection using current methods of prophylaxis. The highest mortality risk was in the early postoperative period, specifically in patients with very high MELD scores. This probably reflects the practice of using positive serology grafts in emergent situations. 相似文献118.
Shenoy RK Kumaraswami V Suma TK Rajan K Radhakuttyamma G 《Annals of tropical medicine and parasitology》1999,93(4):367-377
Acute attacks of adenolymphangitis (ADL) contribute significantly to the morbidity seen in cases of filarial lymphoedema. Such cases are now being treated with multiple courses of the antifilarial drug diethylcarbamazine (DEC), either alone or in combination with antibiotics or anti-inflammatory drugs, based on anecdotal experience. In this, the first double-blind, placebo-controlled study, 150 patients with lymphoedema caused by brugian filariasis, each of whom recalled two or more ADL attacks in the previous year, were enrolled on a comprehensive foot-care programme. Each was also randomly allocated to one of the following five daily regimens (30 patients/regimen) for 1 year: 800 mg oral penicillin; 1 mg DEC/kg; 800 mg oral penicillin plus 1 mg DEC/kg; local antibiotics; or placebo. Each patient was followed up for another year. For each regimen group (including the placebo group), the number of ADL attacks in the treatment year was significantly less than that in the year prior to treatment (P < 0.001). Although, in all but the placebo group, there was a slight increase in the number of episodes in the follow-up year compared with the treatment year, the increase was only significant in the two groups given penicillin. Of all the treatments tested therefore, foot care seems to play the most important role in the prevention of ADL attacks. Additional benefit may accrue from local or systemic antibiotic use in those with high grades of oedema, but antifilarials have no place in the prevention of ADL attacks in an individual patient. These observations should help in the rational management and prevention of ADL attacks in filarial lymphoedema, so that the progression of the disease may be halted and morbidity reduced. 相似文献
119.
Eliza W. Beal Ezra Lyon Joe Kearney Lai Wei Cecilia G. Ethun Sylvester M. Black Mary Dillhoff Ahmed Salem Sharon M. Weber Thuy B. Tran George Poultsides Rivfka Shenoy Ioannis Hatzaras Bradley Krasnick Ryan C. Fields Stefan Buttner Charles R. Scoggins Robert C.G. Martin Carl R. Schmidt 《HPB : the official journal of the International Hepato Pancreato Biliary Association》2017,19(12):1104-1111
Background
The objective of this study is to evaluate use of the American College of Surgeons (ACS) National Surgical Quality Improvement Program (NSQIP) online risk calculator for estimating common outcomes after operations for gallbladder cancer and extrahepatic cholangiocarcinoma.Methods
Subjects from the United States Extrahepatic Biliary Malignancy Consortium (USE-BMC) who underwent operation between January 1, 2000 and December 31, 2014 at 10 academic medical centers were included in this study. Calculator estimates of risk were compared to actual outcomes.Results
The majority of patients underwent partial or major hepatectomy, Whipple procedures or extrahepatic bile duct resection. For the entire cohort, c-statistics for surgical site infection (0.635), reoperation (0.680) and readmission (0.565) were less than 0.7. The c-statistic for death was 0.740. For all outcomes the actual proportion of patients experiencing an event was much higher than the median predicted risk of that event. Similarly, the group of patients who experienced an outcome did have higher median predicted risk than those who did not.Conclusions
The ACS NSQIP risk calculator is easy to use but requires further modifications to more accurately estimate outcomes for some patient populations and operations for which validation studies show suboptimal performance. 相似文献120.