全文获取类型
收费全文 | 8579篇 |
免费 | 750篇 |
国内免费 | 16篇 |
专业分类
耳鼻咽喉 | 226篇 |
儿科学 | 302篇 |
妇产科学 | 223篇 |
基础医学 | 1052篇 |
口腔科学 | 202篇 |
临床医学 | 962篇 |
内科学 | 1737篇 |
皮肤病学 | 241篇 |
神经病学 | 661篇 |
特种医学 | 412篇 |
外科学 | 1511篇 |
综合类 | 199篇 |
一般理论 | 8篇 |
预防医学 | 648篇 |
眼科学 | 152篇 |
药学 | 324篇 |
肿瘤学 | 485篇 |
出版年
2021年 | 92篇 |
2018年 | 101篇 |
2017年 | 87篇 |
2016年 | 81篇 |
2015年 | 112篇 |
2014年 | 145篇 |
2013年 | 228篇 |
2012年 | 294篇 |
2011年 | 305篇 |
2010年 | 194篇 |
2009年 | 171篇 |
2008年 | 273篇 |
2007年 | 337篇 |
2006年 | 335篇 |
2005年 | 334篇 |
2004年 | 294篇 |
2003年 | 335篇 |
2002年 | 312篇 |
2001年 | 268篇 |
2000年 | 287篇 |
1999年 | 257篇 |
1998年 | 87篇 |
1997年 | 81篇 |
1996年 | 89篇 |
1995年 | 86篇 |
1994年 | 80篇 |
1993年 | 82篇 |
1992年 | 239篇 |
1991年 | 239篇 |
1990年 | 225篇 |
1989年 | 249篇 |
1988年 | 200篇 |
1987年 | 212篇 |
1986年 | 207篇 |
1985年 | 197篇 |
1984年 | 173篇 |
1983年 | 118篇 |
1982年 | 88篇 |
1979年 | 142篇 |
1978年 | 107篇 |
1976年 | 86篇 |
1974年 | 96篇 |
1973年 | 150篇 |
1972年 | 87篇 |
1971年 | 101篇 |
1970年 | 107篇 |
1969年 | 97篇 |
1968年 | 81篇 |
1967年 | 81篇 |
1966年 | 80篇 |
排序方式: 共有9345条查询结果,搜索用时 31 毫秒
51.
52.
The case report describes a distinct variant of non-REM (Rapid Eye Movement) arousal parasomnia, sleepwalking type, featuring repetitive abrupt arousals, mostly from slow-wave sleep, and various automatisms and semi-purposeful behaviours. The frequency of events and distribution throughout the night presented as a continuous status of parasomnia (' status parasomnicus '). The patient responded well to treatment typically administered for adult NREM parasomnias, and after careful review of the clinical presentation, objective findings and treatment outcome, sleep-related epilepsy was ruled out in favour of parasomnia. 相似文献
53.
Ron Shapiro James B. Young Edgar L. Milford James F. Trotter Rami T. Bustami Alan B. Leichtman 《American journal of transplantation》2005,5(4P2):874-886
Immunosuppression trends for solid organ transplantation have undergone a perceptible shift over the past decade. This period is of interest because it was during this time that the Food and Drug Administration (FDA) expanded the variety of medications to allow for alternatives in immunosuppressive management. An organ-by-organ review of SRTR data identifies several important trends. Antibody induction continues to be used for the majority of kidney (70%) , simultaneous pancreas-kidney (SPK, 79%) pancreas after kidney (PAK, 74%), and intestine recipients (74%). It is used for under half of thoracic organ recipients and remains uncommon for liver transplant recipients (20%). The type of antibody preparation utilized has shifted from muromonab-CD3 and horse ATG to rabbit ATG and monoclonal anti-IL-2 receptor antagonists. Calcineurin inhibitors continue to be used for maintenance immunosuppression for most recipients, although there has been a shift from cyclosporine to tacrolimus. A clear transition is apparent in the choice of antimetabolite from azathioprine to mycophenolate mofetil. Although corticosteroids continue to be used as maintenance immunosuppression for most recipients prior to discharge, there is evidence that efforts of steroid avoidance protocols are having an impact across all organs, as slight decreases in their use have been observed. 相似文献
54.
M Walter C G McDonald B W Paty A M J Shapiro E A Ryan P A Senior 《Diabetic medicine》2007,24(2):161-165
AIMS: Autoimmune diseases such as Addison's or coeliac disease can contribute to hypoglycaemia or malabsorption and are more common in Type 1 diabetes (T1DM). This brief report describes the prevalence of known and newly detected autoimmune disease in clinical islet transplant candidates with longstanding T1DM and severe hypoglycaemia and/or glycaemic lability who are routinely screened for coexisting autoimmune disease. METHODS: One hundred and twenty-four C-peptide negative T1DM subjects [77 (62%) female, mean age 44 +/- 9 years, diabetes duration 28 +/- 11 years, body mass index 24.9 +/- 3.5 kg/m(2)] with indications for clinical islet transplantation at the University of Alberta were screened for autoimmune disease by history and measurement of anti-transglutaminase antibodies (positive > 10 U/ml), 09.00 h cortisol (followed by adrenocorticotrophic hormone-stimulation if < 495 nmol/l) and thyroid-stimulating hormone to determine the prevalence of coeliac disease, Addison's disease and autoimmune thyroid disease, respectively. RESULTS: Forty per cent of subjects had one or more coexisting autoimmune disease. The prevalence of autoimmune disease was 35%, coeliac disease 8% and Addison's disease 1.6%. In 11 individuals (9%), one or more autoimmune disease were newly detected (seven coeliac disease and five thyroid disease). Seven of 10 cases of coeliac disease were newly detected. A gluten-free diet in individuals with newly diagnosed coeliac disease reduced gastrointestinal symptoms, but indications for clinical islet cell transplantation persisted. CONCLUSIONS: Coexisting autoimmune disease is common in candidates for clinical islet cell transplantation. Screening in this group identified a substantial number of previously unrecognized cases. Clinicians should consider the presence of autoimmune disease even in the absence of classical symptoms. 相似文献
55.
56.
Infected renal stones can be treated by extracorporeal shock wave lithotripsy but it still is not clear whether successful stone fragmentation and the disappearance of all macroscopic stone fragments guarantee eradication of the infection. Therefore, a prospective study was done in 135 patients with renal or upper ureteral stones associated with persistent urinary tract infection. The urinary infection was localized in each patient by bilateral ureteral catheterization. Upper tract infection in the kidney containing the stone was found in 75.6 per cent of the cases. A total of 94 patients completed treatment with extracorporeal shock wave lithotripsy and were followed for 3 to 16 months (mean followup 6.4 months). A marked correlation between the incidence of residual macroscopic stone fragments and the presence of persistent infection was noted. Of the 51 patients who became free of stones 48 (94 per cent) had sterile urine. Only 3 of the 51 patients had persistent infection in the treated kidney despite complete disappearance of the stones. In 45 of the 59 patients with stones smaller than 2 cm. (76 per cent) the infection was eradicated, whereas of the 35 with larger stones the urine became sterile in only 13 (37 per cent). We conclude that extracorporeal shock wave lithotripsy can be endorsed for treatment of small infected stones but it is inadequate for treatment of stones larger than 2 cm. unless combined with percutaneous nephrolithotripsy or chemical dissolution of the residual infected fragments. 相似文献
57.
Robert M. Pascuzzi Scott A. Shapiro Aruna N. Rau Charles E. Schultz Robin M. Bowman Karen S. Caldemeyer David S. Wilkes David S. Wilkes 《Journal of neuroimaging》1996,6(1):61-62
A 45-year-old woman with history of iritis, uveitis, and sarcoidosis of the skin presented with a subacute cervical myelopathy. Magnetic resonance imaging (MRI) ;howed patchy, multifocal, gadoliniumenhancing intramedullary lesions of the spinal cord, and extramedullary lesions of the basal cisterns and fourth ventricle. Symptoms and MRI abnormalities were improved within 1 month of corticosteroid therapy. 相似文献
58.
B A Akbarnia J Shapiro M Ziaee N O Akbarnia 《The Journal of bone and joint surgery. American volume》1990,72(9):1330-1333
Severe hypertension occurred as a postoperative complication after correction of a club-foot deformity in four children (seven feet) who were between the ages of two and three years and had no history of hypertension. The hypertension subsided slowly after administration of antihypertensive medications or more rapidly after release of the correction that had been obtained operatively. 相似文献
59.
Onelio Geatti Brahm Shapiro Pier Giuseppe Orsolon Gianni Proto Ugo Paolo Guerra Francesco Antonucci Daniele Gasparini 《European journal of nuclear medicine and molecular imaging》1994,21(1):17-22
Technetium-99m methoxyisobutylisonitrile (MIBI), like thallium-201, has recently been introduced as a myocardial perfusion agent and is now also showing very promising results in parathyroid scintigrapy. The results of 201Tl/99mTc-pertechnetate and 99mTc-MIBI/99mTc-pertechnetate subtraction scintigraphy, ultrasonography and computed tomography are presented in a series of 43 patients operated on for hyperparathyroidism. All four imaging modalities were confirmed to be reliable, scintigraphy being the most accurate. Sensitivities ranged from 81% to 95%, that of 99mTc-MIBI being the highest. Moreover this tracer, which has more favourable physical and also biochemical properties, yielded images of superior quality. This allowed localization of the lesion by visual inspection only in as many as 86% of the patients with positive 99mTc-MIBI/99mTc-pertechnetate subtraction scintigraphy. We believe that the higher sensitivity, superior image quality and lower cost of 99mTc-MIBI imaging will make 99mTc-MIBI the new radiopharmaceutical of choice for parathyroid scintigraphy (when one takes into account the stability of labelling with large activities it is possible to perform three or four cardiac studies together with one parathyroid scintigraphic examination using one lyophililzed vial). 相似文献
60.
G S Fisch L R Shapiro R Simensen C E Schwartz J P Fryns M Borghgraef L M Curfs P N Howard-Peebles T Arinami A Mavrou 《American journal of medical genetics》1992,43(1-2):28-34
Longitudinal changes in IQ among mentally retarded (MR) fragile X [fra(x)] males have been reported previously. While age is associated with decline in IQ, not all males are so affected. This suggests that there may be more than one subtype of affected fra(X) male. Therefore, we examined the distribution of standardized difference scores (Zdiff) in IQ to determine if subjects were from an admixture of at least 2 populations. Cluster analysis of Zdiff scores was used to partition subjects into 2 groups. Goodness-of-fit tests indicated that scores were more likely to come from an admixture. Discriminant functions (DF) were calculated to determine predictive validity of Zdiff scores. To eliminate the effect of skewing, a power transform was applied to Zdiff scores and DFs recomputed. Zdiff and transformed scores provided similar results. The mean and variance for one group showed no differences in test-retest scores as would be expected from examining any population while the mean for the second group indicated significant decline in IQ nearly 4 standard errors below the first test score. These results suggest that there may be clinical evidence for 2 types of fra(X) mutation: One which causes MR but is static, and a second mutation which causes MR but is dynamic and contributes to an apparent longitudinal decline in cognitive function. 相似文献