全文获取类型
收费全文 | 3843篇 |
免费 | 200篇 |
国内免费 | 17篇 |
专业分类
耳鼻咽喉 | 40篇 |
儿科学 | 187篇 |
妇产科学 | 118篇 |
基础医学 | 457篇 |
口腔科学 | 149篇 |
临床医学 | 278篇 |
内科学 | 745篇 |
皮肤病学 | 111篇 |
神经病学 | 209篇 |
特种医学 | 126篇 |
外科学 | 439篇 |
综合类 | 151篇 |
一般理论 | 6篇 |
预防医学 | 276篇 |
眼科学 | 85篇 |
药学 | 296篇 |
中国医学 | 13篇 |
肿瘤学 | 374篇 |
出版年
2023年 | 42篇 |
2022年 | 97篇 |
2021年 | 161篇 |
2020年 | 89篇 |
2019年 | 100篇 |
2018年 | 146篇 |
2017年 | 105篇 |
2016年 | 127篇 |
2015年 | 124篇 |
2014年 | 166篇 |
2013年 | 205篇 |
2012年 | 309篇 |
2011年 | 281篇 |
2010年 | 151篇 |
2009年 | 125篇 |
2008年 | 225篇 |
2007年 | 208篇 |
2006年 | 189篇 |
2005年 | 181篇 |
2004年 | 138篇 |
2003年 | 102篇 |
2002年 | 129篇 |
2001年 | 56篇 |
2000年 | 58篇 |
1999年 | 46篇 |
1998年 | 27篇 |
1997年 | 18篇 |
1996年 | 23篇 |
1995年 | 21篇 |
1994年 | 17篇 |
1993年 | 9篇 |
1992年 | 26篇 |
1991年 | 18篇 |
1990年 | 29篇 |
1989年 | 22篇 |
1988年 | 29篇 |
1987年 | 20篇 |
1986年 | 16篇 |
1985年 | 15篇 |
1984年 | 18篇 |
1983年 | 12篇 |
1982年 | 7篇 |
1981年 | 10篇 |
1979年 | 11篇 |
1978年 | 7篇 |
1976年 | 9篇 |
1973年 | 9篇 |
1972年 | 7篇 |
1971年 | 7篇 |
1941年 | 6篇 |
排序方式: 共有4060条查询结果,搜索用时 0 毫秒
71.
72.
73.
Longitudinal variations of laryngeal overpressure and voice‐related quality of life in spasmodic dysphonia 下载免费PDF全文
74.
Eriko Kikuchi Takayasu Mori Moko Zeniya Kiyoshi Isobe Mari Ishigami-Yuasa Shinya Fujii Hiroyuki Kagechika Tomoaki Ishihara Tohru Mizushima Sei Sasaki Eisei Sohara Tatemitsu Rai Shinichi Uchida 《Journal of the American Society of Nephrology : JASN》2015,26(7):1525-1536
Upon activation by with-no-lysine kinases, STE20/SPS1-related proline–alanine-rich protein kinase (SPAK) phosphorylates and activates SLC12A transporters such as the Na+-Cl− cotransporter (NCC) and Na+-K+-2Cl− cotransporter type 1 (NKCC1) and type 2 (NKCC2); these transporters have important roles in regulating BP through NaCl reabsorption and vasoconstriction. SPAK knockout mice are viable and display hypotension with decreased activity (phosphorylation) of NCC and NKCC1 in the kidneys and aorta, respectively. Therefore, agents that inhibit SPAK activity could be a new class of antihypertensive drugs with dual actions (i.e., NaCl diuresis and vasodilation). In this study, we developed a new ELISA-based screening system to find novel SPAK inhibitors and screened >20,000 small-molecule compounds. Furthermore, we used a drug repositioning strategy to identify existing drugs that inhibit SPAK activity. As a result, we discovered one small-molecule compound (Stock 1S-14279) and an antiparasitic agent (Closantel) that inhibited SPAK-regulated phosphorylation and activation of NCC and NKCC1 in vitro and in mice. Notably, these compounds had structural similarity and inhibited SPAK in an ATP-insensitive manner. We propose that the two compounds found in this study may have great potential as novel antihypertensive drugs. 相似文献
75.
Urinary Kidney injury molecule‐1 can predict delayed graft function in living donor renal allograft recipients 下载免费PDF全文
76.
Vandana Rai 《Metabolic brain disease》2016,31(4):727-735
Autism (MIM 209850) is a heterogeneous neurodevelopmental disease that manifests within the first 3 years of life. Numerous articles reported that dysfunctional folate-methionine pathway enzymes may play an important role in the pathophysiology of autism. Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme of this pathway and MTHFR C677T polymorphism reported as risk factor for autism in several case control studies. However, controversial reports were also published. Hence the present meta-analysis was designed to investigate the relationship of the MTHFR C677T polymorphism with the risk of autism. Electronic databases were searched for case control studies with following search terms - ‘MTHFR’, ‘C677T’, in combination with ‘Autism’. Pooled OR with its corresponding 95 % CI was calculated and used as association measure to investigate the association between MTHFR C677T polymorphism and risk of autism. Total of thirteen studies were found suitable for the inclusion in the present meta-analysis, which comprises 1978 cases and 7257 controls. Meta-analysis using all four genetic models showed significant association between C677T polymorphism and autism (ORTvs.C = 1.48; 95 % CI: 1.18–1.86; P = 0.0007; ORTT + CT vs. CC = 1.70, 95 % CI = 0.96–2.9, p = 0.05; ORTT vs. CC = 1.84, 95 % CI = 1.12–3.02, p = 0.02; ORCT vs.CC = 1.60, 95 % CI = 1.2–2.1, p = 0.003; ORTT vs.CT+CC = 1.5, 95 % CI = 1.02–2.2, p = 0.03). In total 13 studies, 9 studies were from Caucasian population and 4 studies were from Asian population. The association between C677T polymorphism and autism was significant in Caucasian (ORTvs.C = 1.43; 95 % CI = 1.1–1.87; p = 0.009) and Asian population (ORTvs.C = 1.68; 95 % CI = 1.02–2.77; p = 0.04) using allele contrast model. In conclusion, present meta-analysis strongly suggested a significant association of the MTHFR C677T polymorphism with autism. 相似文献
77.
Miyata M Sakuma F Fukaya E Kobayashi H Rai T Saito H Kasukawa R Suzuki S 《Internal medicine (Tokyo, Japan)》2002,41(6):467-473
The applicability of monitoring concentrations of serum KL-6 and serum surfactant protein-D (SP-D) in the detection of methotrexate-associated lung injury (MTX pneumonitis) in patients with rheumatoid arthritis (RA) was investigated. The concentrations of these markers, sequentially measured in two patients with RA complicated with MTX pneumonitis, were increased in accordance with the severity of MTX pneumonitis. Conversely, the concentrations of these markers were decreased with the improvement of MTX pneumonitis, suggesting that the monitoring of these markers could be applicable not only for detecting the onset of MTX pneumonitis, but also for detecting the therapeutic response of MTX pneumonitis. 相似文献
78.
Tyler F. Beck Philippe M. Campeau Shalini N. Jhangiani Tomasz Gambin Alexander H. Li Reem Abo‐Zahrah Valerie K. Jordan Andres Hernandez‐Garcia Wojciech K. Wiszniewski Donna Muzny Richard A. Gibbs Eric Boerwinkle James R. Lupski Brendan Lee Willie Reardon Daryl A. Scott 《American journal of medical genetics. Part A》2015,167(4):831-836
79.
Exome sequencing identifies a homozygous C5orf42 variant in a Turkish kindred with oral‐facial‐digital syndrome type VI 下载免费PDF全文
80.