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101.
102.
W. Rabe 《Journal of neurology》1970,198(3):342-348
Zusammenfassung Es wird über einen 42jährigen Mann berichtet, bei dem durch direkte Punktion der Arteria carotis communis ein extrakranieller Verschluß der Arteria carotis interna angiographisch nachgewiesen wurde. Das Angiogramm zeigt einen seltenen Kollateralkreislauf, der aus einem Netz erweiterter Gefäße zwischen der Arteria maxillaris und der Arteria carotis interna besteht. Anlaß der Untersuchung war ein Bagatelltrauma des Kopfes, bei dem der Patient kurze Zeit unter Schwindel und Flimmern vor den Augen litt. Tage danach traten langsam zunehmende Kopfschmerzen auf, die den Patienten 6 Monate nach dem Unfall zur Untersuchung in die Klinik führten. Neurologisch und psychopathologisch ergaben sich regelrechte Befunde. Gefäße der dargestellten Art kommen im normalen Angiogramm nicht vor. Es wird vermutet, daß ihr Vorhandensein entwicklungsgeschichtlich zu verstehen ist und daß der Gefäßverschluß in früher Kindheit eingetreten ist.
A rare collateral circulation between the maxillary and internal carotid artery
Summary In a 42-year-old man an extracranial occlusion of the internal carotid artery was detected through angiography by direct puncture of the common carotid artery. The angiogram revealed a rarely seen collateral circulation consisting of a network of dilated vessels between the maxillary artery and the internal carotid artery. The reason for the examination arose when he suffered a minimal head trauma associated with a short episode of dizziness and flickering vision. A few days later he developed headaches which grew gradually worse to make the patient finally come to the hospital 6 months after the trauma. Neurological and psychopathological findings were normal. The described alterations of blood vessels are not seen on a normal angiogram and presumably represent a developmental abnormality; the extracranial occlusion of the internal carotid artery has possibly occurred in early childhood.相似文献
103.
104.
Behjati F Atri M Najmabadi H Nouri K Zamani M Mehdipour P 《Pathology oncology research : POR》2005,11(3):157-163
Breast cancer is amongst the leading causes of death in women worldwide and the most common cancer amongst Iranian women.
Unfortunately, the current clinical and histological criteria can only help 60 percent of women with breast cancer in diagnosis
and long-term treatment. Therefore, genetic markers both at single gene and chromosomal level can play an important role in
improving the diagnosis and prognosis of breast cancer patients. The aim of this retrospective study was to investigate the
role of chromosome 1 and 8 copy number assessed by interphase fluorescence in situ hybridization (FISH), as prognostic parameters
in 50 Iranian women, aged 35 to 64 years, with sporadic invasive ductal breast carcinoma. Chromosome 1 and 8 copy numbers
were evaluated in relation to established clinicopathological parameters, the immunohistochemical markers ER, PR, P53 and
cathepsin D, DNA index by flow cytometry, age and survival status of the patients. FISH using centromeric probes for chromosomes
1 and 8 was applied to interphase cell suspensions prepared from archived, Carnoyfixed tumor cells and selected paraffin-embedded
tumor sections. Aneusomy for chromosomes 1 and 8 was present in all 50 patients to different levels. The total abnormality
rate for chromosome 1 was 33.92 percent (4.24 percent monosomy and 29.68 percent polysomy), whereas for chromosome 8 this
rate was 28.30 percent (6.48 percent monosomy and 21.82 percent polysomy). Statistically significant association (p<0.05)
was demonstrated between monosomy 1 and patients’ age below 50 years, and between monosomy 1 and poor survival, respectively.
Disomy 8 was significantly associated with P53 expression. A borderline significant correlation was demonstrated between polysomy
8 and diploid DNA content, as well as between disomy 1 and disease-free status of the patients. Chromosome 1 and 8 copy numbers
may be considered as useful prognostic markers in invasive ductal carcinoma of the breast. 相似文献
105.
Malekirad AA Ranjbar A Rahzani K Pilehvarian AA Rezaie A Zamani MJ Abdollahi M 《Environmental toxicology and pharmacology》2005,20(1):215-218
Excessive production of reactive oxygen species has been observed following acute and chronic exposure to radiation in animal models which can lead to several detrimental and irreversible outcomes in vital organs. Aim of this study was to determine the oxidative stress status in radiology unit workers which are exposed to persistent low-dose radiation. METHODS:: A group of 32 radiology unit employees along with 32 sex- and age-matched hospital workers, not exposed to low-dose radiation were recruited from two separate hospitals for the study. Exposed subjects showed higher levels of lipid peroxidation (P=0.009), total antioxidant capacity (P=0.0006) and thiol groups (P=0.03). It is concluded that occupationally exposed individuals are oxidatively stressed and precautions such as antioxidant therapy seems reasonable. 相似文献
106.
Endoscopic ultrasound added to mediastinoscopy for preoperative staging of patients with lung cancer 总被引:5,自引:0,他引:5
Annema JT Versteegh MI Veseliç M Welker L Mauad T Sont JK Willems LN Rabe KF 《JAMA》2005,294(8):931-936
Context Up to 40% of thoracotomies performed for nonsmall cell lung cancer are unnecessary, predominantly due to inaccurate preoperative detection of lymph node metastases and mediastinal tumor invasion (T4). Mediastinoscopy and the novel, minimally invasive technique of transesophageal ultrasoundguided fine-needle aspiration (EUS-FNA) target different mediastinal lymph node stations. In addition, EUS can identify tumor invasion in neighboring organs if tumors are located adjacent to the esophagus. Objective To investigate the additional value of EUS-FNA to mediastinoscopy in the preoperative staging of patients with nonsmall cell lung cancer. Design, Setting, and Patients Prospective, nonrandomized multicenter trial performed in 1 referral and 5 general hospitals in the Netherlands. During a 3-year period (2000-2003), 107 consecutive patients with potential resectable nonsmall cell lung cancer underwent preoperative staging by both EUS-FNA and mediastinoscopy. Patients underwent thoracotomy with tumor resection if mediastinoscopy was negative. Surgical-pathological staging was compared with preoperative findings and the added benefit of the combined strategy was assessed. Intervention The EUS-FNA examination was performed as an additional staging test to mediastinoscopy in all patients. Main Outcome Measure Detection of mediastinal tumor invasion (T4) and lymph node metastases (N2/N3) comparing the combined staging by both EUS-FNA and mediastinoscopy with staging by mediastinoscopy alone. Results The combination of EUS-FNA and mediastinoscopy identified more patients with tumor invasion or lymph node metastases (36%; 95% confidence interval [CI], 27%-46%) compared with either mediastinoscopy alone (20%; 95% CI, 13%-29%) or EUS-FNA (28%; 95% CI, 19%-38%) alone. This indicated that 16% of thoracotomies could have been avoided by using EUS-FNA in addition to mediastinoscopy. However, 2% of the EUS-FNA findings were false-positive. Conclusion These preliminary findings suggest that EUS-FNA, when added to mediastinoscopy, improves the preoperative staging of lung cancer due to the complementary reach of EUS-FNA in detecting mediastinal lymph node metastases and the ability to assess mediastinal tumor invasion. 相似文献
107.
Lower cancer incidence in Amsterdam-I criteria families without mismatch repair deficiency: familial colorectal cancer type X 总被引:9,自引:0,他引:9
Lindor NM Rabe K Petersen GM Haile R Casey G Baron J Gallinger S Bapat B Aronson M Hopper J Jass J LeMarchand L Grove J Potter J Newcomb P Terdiman JP Conrad P Moslein G Goldberg R Ziogas A Anton-Culver H de Andrade M Siegmund K Thibodeau SN Boardman LA Seminara D 《JAMA》2005,293(16):1979-1985
Context Approximately 60% of families that meet the Amsterdam-I criteria (AC-I) for hereditary nonpolyposis colorectal cancer (HNPCC) have a hereditary abnormality in a DNA mismatch repair (MMR) gene. Cancer incidence in AC-I families with MMR gene mutations is reported to be very high, but cancer incidence for individuals in AC-I families with no evidence of an MMR defect is unknown. Objective To determine if cancer risks in AC-I families with no apparent deficiency in DNA MMR are different from cancer risks in AC-I families with DNA MMR abnormalities. Design, Setting, and Participants Identification (1997-2001) of 161 AC-I pedigrees from multiple population- and clinic-based sources in North America and Germany, with families grouped into those with (group A) or without (group B) MMR deficiency by tumor testing. A total of 3422 relatives were included in the analyses. Main Outcome Measures Cancer incidence in groups A and B (excluding the 3 affected members used to define each pedigree as AC-I) and computed age- and sex-adjusted standardized incidence ratios (SIRs) using Surveillance, Epidemiology, and End Results data. Results Group A families from both population- and clinic-based series showed increased incidence of the HNPCC-related cancers. Group B families showed increased incidence only for colorectal cancer (SIR, 2.3; 95% confidence interval, 1.7-3.0) and to a lesser extent than group A (SIR, 6.1; 95% confidence interval, 5.2-7.2) (P<.001). Conclusions Families who fulfill AC-I criteria but who have no evidence of a DNA MMR defect do not share the same cancer incidence as families with HNPCC-Lynch syndrome (ie, hereditary MMR deficiency). Relatives in such families have a lower incidence of colorectal cancer than those in families with HNPCC-Lynch syndrome, and incidence may not be increased for other cancers. These families should not be described or counseled as having HNPCC-Lynch syndrome. To facilitate distinguishing these entities, the designation of "familial colorectal cancer type X" is suggested to describe this type of familial aggregation of colorectal cancer. 相似文献
108.
109.
Rabe C Musch A Schirmacher P Kruis W Hoffmann R 《World journal of gastroenterology : WJG》2005,11(2):303-304
110.
Vorbrodt AW Dobrogowska DH Kozlowski PB Rabe A Tarnawski M Lee MH 《Journal of neurocytology》2005,34(6):435-446
The involvement of blood microvessels, representing the anatomic site of the blood-brain barrier (BBB), in brain damage induced
by prenatal exposure to lipopolysaccharide (LPS) and/or valproic acid (VPA) was studied in four-week-old rats. The immunogold
procedure was applied for localization at the ultrastructural level of endogenous albumin and glucose transporter (GLUT-1)
in three brain regions: cerebral cortex, cerebellum and hippocampus. Four groups of rats were used: (1) untreated control,
(2) prenatally VPA-treated, (3) prenatally LPS-treated, and (4) prenatally LPS- and VPA-treated. The functional state of the
BBB was evaluated as follows: (a) by its tightness, i.e., permeability to blood-borne albumin, and (b) by the expression of
GLUT-1 in the endothelial cells (ECs). Using morphometry, the labelling density for GLUT-1 was recorded over luminal and abluminal
plasma membranes of the ECs, also providing information on their functional polarity. No extensive increase of vascular permeability
and/or any considerable dysfunction of the BBB in experimental groups nos. 2 and 3 were observed, although in solitary vascular
profiles, increased endocytosis or even transcytosis of albumin by ECs was noted. In experimental group no. 4, some vascular
profiles showed scanty leakage (microleakage), manifested by the presence of immunosignals for albumin in the perivascular
area. Although some fluctuations in the expression of GLUT-1 occurred in all experimental groups, especially in group no.
3, a most pronounced and significant diminution of the labelling density, in all three regions of the brain, was observed
in group no. 4. This finding suggests the synergistic action of prenatally applied LPS and VPA that affects specific transport
functions of glucose in the microvascular endothelium. The diminished or disturbed supply of glucose to selected brain regions
can be one of the factors leading to previously observed behavioral disturbances in similarly treated rats. 相似文献