全文获取类型
收费全文 | 412篇 |
免费 | 37篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 21篇 |
妇产科学 | 12篇 |
基础医学 | 68篇 |
口腔科学 | 12篇 |
临床医学 | 51篇 |
内科学 | 67篇 |
皮肤病学 | 12篇 |
神经病学 | 29篇 |
特种医学 | 7篇 |
外科学 | 72篇 |
综合类 | 5篇 |
预防医学 | 29篇 |
眼科学 | 7篇 |
药学 | 27篇 |
中国医学 | 3篇 |
肿瘤学 | 26篇 |
出版年
2023年 | 9篇 |
2022年 | 13篇 |
2021年 | 17篇 |
2020年 | 15篇 |
2019年 | 24篇 |
2018年 | 29篇 |
2017年 | 18篇 |
2016年 | 14篇 |
2015年 | 19篇 |
2014年 | 32篇 |
2013年 | 38篇 |
2012年 | 35篇 |
2011年 | 42篇 |
2010年 | 19篇 |
2009年 | 10篇 |
2008年 | 22篇 |
2007年 | 17篇 |
2006年 | 18篇 |
2005年 | 18篇 |
2004年 | 13篇 |
2003年 | 9篇 |
2002年 | 7篇 |
2001年 | 5篇 |
1999年 | 2篇 |
1998年 | 3篇 |
1996年 | 1篇 |
1995年 | 1篇 |
排序方式: 共有450条查询结果,搜索用时 15 毫秒
21.
22.
Circulating Irisin Levels and Redox Status Markers in Patients with Gastric Cancer: A Case-Control Study 下载免费PDF全文
Shabnam ShahidiJalal HejaziMinoosh MoghimiSoheila BorjiSaeed ZabihianMojtaba Fathi 《Asian Pacific journal of cancer prevention》2020,21(10):2847-2851
Objective: Irisin, mostly known as an exercise-induced fat browning myokine, has been recently detected in several cancer cells, and its potential for being utilized as a biomarker for early diagnosis of some cancers, such as Gastric cancer (GC), is the subject of speculation. The present study aims to compare serum irisin levels in GC patients and healthy controls and assess the interrelation between irisin and oxidative stress markers. Methods: In this case-control study, 22 newly diagnosed GC patients and 29 healthy controls were recruited based on the inclusion criteria. Serum levels of irisin were quantified in duplicates by ELISA. Oxidative stress indices, including total antioxidant power in sera, thiol group, malondialdehyde, and superoxide dismutase concentrations, were also measured in both groups. An independent-sample t-test was used to compare the means between the two studied groups. Results: Serum levels of irisin were significantly higher in the GC group compared with those of their healthy counterparts (p =0.032). No significant differences were observed between the two groups in terms of the serum total antioxidant power or the oxidative stress marker, including MDA, thiol groups, and SOD concentration in sera. Furthermore, there was no significant association between irisin, FRAP, the Thiol group, and the SOD activity. Conclusion: According to the finding, the increased serum levels of irisin in GC patients can play a potential role in the early diagnosis of the GC patients; hence, this peptide can be employed as a new diagnostic indicator of GC. 相似文献
23.
Margaret A. DiGuardo Jaime I. Davila Rory A. Jackson Asha A. Nair Numrah Fadra Kay T. Minn Mazen A. Atiq Shabnam Zarei Joseph H. Blommel Shannon M. Knight Jin Jen Bruce W. Eckloff Jesse S. Voss Kandelaria M. Rumilla Sarah E. Kerr Dora M. Lam-Himlin Andrew M. Bellizzi Rondell P. Graham Kevin C. Halling 《The Journal of molecular diagnostics : JMD》2021,23(5):555-564
24.
25.
26.
27.
Marguet CG Springhart WP Tan YH Patel A Undre S Albala DM Preminger GM 《BJU international》2005,96(7):1097-1100
OBJECTIVE: To present early experience in managing complex renal calculi using a combined ureteroscopic and percutaneous approach, as complex and branched renal calculi often require multiple access tracts during percutaneous nephrolithotomy (PNL), and the combined use of flexible ureteroscopy and PNL has the potential to reduce the inherent morbidity of several tracts. PATIENTS AND METHODS: The study included seven patients (mean age 54 years) with multiple, branched, large-volume renal calculi suitable for management with PNL. Preoperative data, including patient demographics, stone location and stone surface area, were recorded. After informed consent, the patients underwent combined PNL and ureteroscopy in one session. Intraoperative data, including the location of PNL puncture sites, operative duration and complications, were analysed. Stone-free rates were determined by follow-up imaging at 3 months. RESULTS: All patients had either two or more stones in separate locations in the collecting system, or staghorn stones involving multiple calyces. The mean stone burden was 666 mm(2). All patients had only one percutaneous access tract. The mean operative duration was 142 min and the mean blood loss 79 mL. Two patients had small residual stones (< 3 mm), that required ureteroscopic intervention as they failed to pass spontaneously by 3 months after the initial combined procedure. The convalescence was similar to that in our current PNL practice; imaging showed that five of the patients were stone-free. CONCLUSIONS: Combined PNL and ureteroscopic management can effectively reduce the number of percutaneous access tracts which would otherwise be required for managing complex and branched renal calculi, as stones in an unfavourable location relative to the access tract can be relocated and fragmented within easy reach of the single nephrostomy tract. This manoeuvre reduces potential patient morbidity and blood loss but with no significant effect on stone-free rates and operative durations. 相似文献
28.
Solid and cystic papillary carcinoma is typically a localized indolent, low-nuclear-grade form of intraductal carcinoma of the breast that occurs in a cystically dilated duct and predominantly affects elderly women in the sixth to the eighth decade of life (mean age, 57 to 75 years). We describe two such lesions, both of high nuclear grade, of larger than average size, that occurred in women in their second decade, one of whom was pregnant. 相似文献
29.
30.
Use of colony morphology to distinguish different enterococcal strains and species in mixed culture from clinical specimens 下载免费PDF全文
Colony morphology on kanamycin esculin azide agar was investigated as a means of selecting different species and strains of enterococci from clinical specimens. Four representative colonies of each morphotype were indistinguishable by pulsed-field gel electrophoresis, biotype, and antibiogram analysis. The optimum time for identification of different colony morphotypes was 72 h. 相似文献