全文获取类型
收费全文 | 6412篇 |
免费 | 447篇 |
国内免费 | 74篇 |
专业分类
耳鼻咽喉 | 110篇 |
儿科学 | 180篇 |
妇产科学 | 89篇 |
基础医学 | 844篇 |
口腔科学 | 256篇 |
临床医学 | 509篇 |
内科学 | 1435篇 |
皮肤病学 | 214篇 |
神经病学 | 349篇 |
特种医学 | 397篇 |
外科学 | 938篇 |
综合类 | 39篇 |
预防医学 | 365篇 |
眼科学 | 161篇 |
药学 | 414篇 |
中国医学 | 66篇 |
肿瘤学 | 567篇 |
出版年
2024年 | 8篇 |
2023年 | 64篇 |
2022年 | 136篇 |
2021年 | 271篇 |
2020年 | 157篇 |
2019年 | 194篇 |
2018年 | 237篇 |
2017年 | 202篇 |
2016年 | 281篇 |
2015年 | 322篇 |
2014年 | 349篇 |
2013年 | 383篇 |
2012年 | 575篇 |
2011年 | 518篇 |
2010年 | 327篇 |
2009年 | 209篇 |
2008年 | 368篇 |
2007年 | 349篇 |
2006年 | 320篇 |
2005年 | 312篇 |
2004年 | 275篇 |
2003年 | 223篇 |
2002年 | 187篇 |
2001年 | 114篇 |
2000年 | 109篇 |
1999年 | 95篇 |
1998年 | 29篇 |
1997年 | 18篇 |
1996年 | 15篇 |
1995年 | 11篇 |
1994年 | 18篇 |
1993年 | 14篇 |
1992年 | 25篇 |
1991年 | 40篇 |
1990年 | 18篇 |
1989年 | 24篇 |
1988年 | 18篇 |
1987年 | 14篇 |
1986年 | 11篇 |
1985年 | 12篇 |
1982年 | 6篇 |
1981年 | 6篇 |
1980年 | 6篇 |
1979年 | 13篇 |
1978年 | 4篇 |
1974年 | 4篇 |
1973年 | 5篇 |
1972年 | 4篇 |
1970年 | 4篇 |
1966年 | 6篇 |
排序方式: 共有6933条查询结果,搜索用时 14 毫秒
91.
Jing Qi Yuman Fong Leonard Saltz Michael I. D'Angelica Nancy E. Kemeny Mithat Gonen Jinru Shia Amita Shukla‐Dave William M. Jarnagin Richard K. G. Do Lawrence H. Schwartz Jason A. Koutcher Kristen L. Zakian 《NMR in biomedicine》2013,26(2):204-212
Hepatic steatosis is a hallmark of chemotherapy‐induced liver injury. We made serial 1H MRS measurements of hepatic lipids in patients over the time course of a 24‐week chemotherapeutic regimen to determine whether 1H MRS could be used to monitor the progression of chemotherapy‐induced steatosis. Thirty‐four patients with stage III or IV colorectal cancer receiving 5‐fluorouracil, folinic acid and oxaliplatin (n = 21) or hepatic arterial infusion of floxuridine with systemic irinotecan (n = 13) were studied prospectively. 1H MRS studies were performed at baseline and after 6 and 24 weeks of treatment. A 1H MR spectrum was acquired from the liver during a breath hold and the ratio of fat to fat + water (FFW) was calculated to give a measure of hepatic triglycerides (HTGCs). The methodology was histologically validated in 18 patients and the reproducibility was assessed in 16 normal volunteers. Twenty‐seven patients completed baseline, 6‐week and 24‐week 1H MRS examinations and one was censored. Thirteen of 26 patients (50%) showed an increase in FFW after completion of treatment. Six patients (23%) developed hepatic steatosis and two patients converted from steatosis to nonsteatotic liver. Patients whose 6‐week hepatic lipid levels had increased significantly relative to baseline also had a high probability of lipid elevation relative to baseline at the completion of treatment. Serial 1H MRS is effective for the monitoring of HTGC changes during chemotherapy and for the detection of chemotherapy‐associated steatosis. Six of 26 patients developed steatosis during chemotherapy. Lipid changes were observable at 6 weeks. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献
92.
93.
Gülçin Altinok A. Işin Doğan Ş. Özgür Aydin Gökhan Gedikoğlu 《Journal of plastic surgery and hand surgery》2013,47(1):56-59
We report four cases of cutaneous, and one of subcutaneous, leiomyosarcoma with the results of histological examinations and immunohistochemical studies. likelihood of metastases than the cutaneous type. Only one of our cutaneous leiomyosarcomas recurred after 18 months and the patient with a subcutaneous lesion had lung metastases after five years. Subcutaneous leiomyosarcomas have more 相似文献
94.
Jennifer B. Dowd Nalini Ranjit D. Phuong Do Elizabeth A. Young James S. House George A. Kaplan 《Annals of behavioral medicine》2011,41(1):13-20
Background
Dysregulation of the hypothalamic–pituitary–adrenal axis is hypothesized to be an important pathway linking socioeconomic position and chronic disease. 相似文献95.
96.
97.
98.
This is preliminary study assessing the efficacy and safety of concurrent use of radiation therapy (RT) and T-DM1 for the treatment of brain metastases (BM) in patients with HER2-positive metastatic breast cancer (BC). We retrospectively studied 12 patients treated for BM at the Institut Curie in 2014–2015 with T-DM1 and concurrent (4) or sequential (8) radiosurgery with or without whole brain irradiation. The following variables were studied: local control, clinical and radiological response as well as early and late side effects. The mean age of the population was 38 years at the time of diagnosis of BC and 46 years at of BM. All patients were with good PS. The response rate of the concurrent treatment group was 75?% with 1 complete response, 1 partial response, one stable disease and 1 progression. Comparatively, the response rate in the sequential group was as follows: two complete responses, two partial responses, six cases of stable disease and two cases of local progression. No patient experienced interruption of irradiation because of side effects. About 50?% of patients were asymptomatic after treatment. Radiation necrosis was observed in 50?% of patients in the concurrent group and 28.6?% of patients in the sequential group with a similar rate of oedema in the two groups. We found that the combination of T-DM1 and radiosurgery was feasible but can increase the incidence of radiation necrosis. Larger prospective studies with longer follow-up are needed to more clearly evaluate this association. 相似文献
99.
100.
Case of punctate palmoplantar keratoderma type I treated with combination of low‐dose oral acitretin and topical salicylic acid and steroid
下载免费PDF全文
![点击此处可从《The Journal of dermatology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Palmoplantar keratodermas (PPK) are heterogeneous disorders characterized by abnormal keratinization. Especially, punctate PPK (PPPK), one of the subtypes of hereditary PPK, is a rare punctate keratoderma characterized by tiny “raindrop” keratoses having a tendency to coalesce on the edge of soles, which are exposed to sustained pressure. If typical punctate lesions are confined to the palms and soles and the patient has a family history and late onset, it can be considered as PPPK type I (PPKP1), also called Buschke–Fisher–Brauer disease. The exact etiology of PPPK has not been fully understood. Furthermore, no standardized treatment for PPPK has been established and treatment options are limited. Above all, traditional systemic retinoids have been used in several cases, but dose‐related adverse effects are common. Therefore, combination of low‐dose systemic retinoids and adjuvant topical therapy can be an alternative treatment option for PPPK. Herein, we report a case of PPKP1 treated with combination of low‐dose oral acitretin (10 mg/day) and topical salicylic acid and steroid. Despite low capacity, low‐dose acitretin showed excellent regression of the lesions by combined use of topical ointments. The supplementary topical therapy may be useful in reducing the dose of systemic retinoids and preventing potential toxicity. 相似文献