全文获取类型
收费全文 | 81篇 |
免费 | 5篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 1篇 |
基础医学 | 15篇 |
口腔科学 | 1篇 |
临床医学 | 18篇 |
内科学 | 24篇 |
皮肤病学 | 1篇 |
神经病学 | 1篇 |
特种医学 | 5篇 |
外科学 | 7篇 |
预防医学 | 3篇 |
药学 | 1篇 |
肿瘤学 | 6篇 |
出版年
2023年 | 1篇 |
2022年 | 4篇 |
2021年 | 6篇 |
2020年 | 2篇 |
2019年 | 4篇 |
2018年 | 5篇 |
2017年 | 2篇 |
2016年 | 1篇 |
2015年 | 6篇 |
2014年 | 6篇 |
2013年 | 5篇 |
2012年 | 9篇 |
2011年 | 8篇 |
2010年 | 6篇 |
2009年 | 4篇 |
2008年 | 2篇 |
2007年 | 4篇 |
2006年 | 8篇 |
2005年 | 1篇 |
1999年 | 1篇 |
1998年 | 1篇 |
排序方式: 共有86条查询结果,搜索用时 15 毫秒
11.
12.
Adil S. Akthar Matthew Koshy Mark K. Ferguson Septimiu Murgu D. Kyle Hogarth Daniel W. Golden Philip P. Connell Erik M. Davies Eric Kowalski Renuka Malik 《Clinical lung cancer》2018,19(2):e227-e233
Background
In this study we sought to determine if staging endoscopic bronchial ultrasound (EBUS) improves outcomes in stage I non–small-cell lung cancer (NSCLC) patients who received hypofractionated radiation therapy (HFRT).Patients and Methods
Patients with stage I NSCLC treated with HFRT from 2008 to 2015 were retrospectively identified from 3 affiliated institutions. All patients underwent positron emission tomography/computed tomography staging and a subset of patients received pretreatment EBUS. Patients with and without pre-radiation therapy EBUS were compared for baseline characteristics. The log rank test was used to compare Kaplan–Meier estimates. Univariate analysis (UVA) and multivariable analysis (MVA) were used to analyze the effect of factors on disease-free survival (DFS) and overall survival (OS).Results
Ninety-two patients met study criteria. Median follow-up for the entire cohort was 21 months. Two-year DFS and OS were 63% and 81%, respectively. Two-year freedom from local, regional, and distant failure were 93%, 87%, and 87%, respectively. Thirty-seven of 92 patients (40%) received pretreatment EBUS. There were no statistically significant differences in 2-year freedom from regional failure rates, DFS, or OS for EBUS-staged versus non–EBUS-staged patients. On UVA, smaller tumor size (P = .03) and higher performance status (P = .05) were associated with improved OS. On MVA, tumor size retained significance for improved OS (hazard ratio [HR], 0.44; 95% confidence interval [CI], 0.19-0.97; P = .04) and higher performance status showed a trend toward improved OS (HR, 0.51; 95% CI, 0.23-1.11; P = .09).Conclusion
In this retrospective series, we did not detect a difference in regional failure or survival outcomes among stage I NSCLC patients who received invasive staging with EBUS before HFRT. 相似文献13.
14.
15.
M Honarvar RS Sahebjavaher SE Salcudean R Rohling 《Physics in medicine and biology》2012,57(19):5909-5927
We consider the inverse problem of continuum mechanics with the tissue deformation described by a mixed displacement-pressure finite element formulation. The mixed formulation is used to model nearly incompressible materials by simultaneously solving for both elasticity and pressure distributions. To improve numerical conditioning, a common solution to this problem is to use regularization to constrain the solutions of the inverse problem. We present a sparsity regularization technique that uses the discrete cosine transform to transform the elasticity and pressure fields to a sparse domain in which a smaller number of unknowns is required to represent the original field. We evaluate the approach by solving the dynamic elastography problem for synthetic data using such a mixed finite element technique, assuming time harmonic motion, and linear, isotropic and elastic behavior for the tissue. We compare our simulation results to those obtained using the more common Tikhonov regularization. We show that the sparsity regularization is less dependent on boundary conditions, less influenced by noise, requires no parameter tuning and is computationally faster. The algorithm has been tested on magnetic resonance elastography data captured from a CIRS elastography phantom with similar results as the simulation. 相似文献
16.
Ramin S. Sahebjavaher Ali Baghani Mohammad Honarvar Ralph Sinkus Septimiu E. Salcudean 《Magnetic resonance in medicine》2013,69(2):411-420
This article presents a new approach to magnetic resonance elastography of the prostate using transperineal mechanical excitation. This approach is validated using a prostate elasticity phantom and in vivo studies of healthy volunteers. It is demonstrated that the transperineal approach can generate shear wave amplitudes on the order of 6–30 μm in the mid‐gland region. The driver was implemented using an electromagnetic actuator with a hydraulic transmission system. The magnetic resonance elastography acquisition time has been reduced significantly by using a “second harmonic” approach. Displacement fields are processed using the established three‐dimensional local frequency estimation algorithm. The three‐dimensional curl‐based direct inversion was used to calculate the local wavelength. The traveling wave expansion algorithm was used to reconstruct the wave damping image for one case. Using the proposed method, it was possible to resolve lesions of 0.5 cc in the phantom study. Repeatability experiments were performed and analyzed. The results from this study indicate that transperineal magnetic resonance elastography—without an endorectal coil—is a suitable candidate for a patient study involving multiparametric magnetic resonance imaging of prostate cancer, where magnetic resonance elastography may provide additional information for improved diagnosis and image‐based surveillance. Magn Reson Med, 2013. © 2012 Wiley Periodicals, Inc. 相似文献
17.
Jeffrey M. Abeysekera Mohammad Najafi Robert Rohling Septimiu E. Salcudean 《Ultrasound in medicine & biology》2014
Tracking the position and orientation of a 3-D ultrasound transducer has many clinical applications. Tracking requires calibration to find the transformation between the tracking sensor and the ultrasound coordinates. Typically the set of image slice data are scan converted to a Cartesian volume using assumed motor geometry and a single transformation to the sensor. We propose, instead, the calibration of individual slices using a 2-D calibration technique. A best fit to a subset of slices is performed to decrease data collection time compared with that for calibration of all slices, and to reduce the influence of random errors in individual calibrations. We compare our technique with four scan conversion-based techniques: 2-D N-wire on the center slice, N-wire using a 3-D volume, N-wire using a 3-D volume including the edge points and a new closed-form planar method using a 3-D volume. The proposed multi-slice technique produced the smallest point reconstruction error (0.82 mm using a tracked stylus). 相似文献
18.
Ajay Wagh Elliot Ho Septimiu Murgu Douglas Kyle Hogarth 《Journal of thoracic disease》2020,12(12):7683
With recommendations for low dose CT scan for lung cancer screening, there has been an increase in the finding of lung nodules and peripheral pulmonary lesions (PPLs). Additionally, when there is concern for malignancy, guidelines have recommended performing the least invasive evaluation. Conventional bronchoscopy diagnostic yields for PPLs have reportedly been quite low and prior electromagnetic navigation bronchoscopy (ENB) studies have reported variable yields. Navigation bronchoscopy in addition to endobronchial ultrasound allows a physician to evaluate peripheral lung lesions along with mediastinal and hilar lymph nodes for the diagnosis and staging of suspected malignancy in one procedure. More recent advances in navigational bronchoscopy including the use of augmented fluoroscopy (AF), cone beam CT, and robotic bronchoscopy have pushed the boundaries of capability in evaluating PPLs. These added bronchoscopic technologies have shown to improve diagnostic yield especially when modalities are used in combination. The ultimate goal of endoscopically localized ablative and therapeutic treatment for peripheral lung lesions will require a high level of physician confidence, accuracy, and precision. This article will review the innovative characteristics and data of some of the more recently available navigational bronchoscopy devices. 相似文献
19.
Mărginean Cristina Oana Bănescu Claudia Duicu Carmen Pitea Ana Maria Voidăzan Septimiu Mărginean Claudiu 《European journal of pediatrics》2014,173(10):1285-1296
The aim of this study was to establish the correlations between the polymorphisms of the genes interleukin (IL)-6 572, 190, and 174 in obese children. We assessed 222 hospitalized children divided into two groups: group I (control) included 110 patients with normal nutritional status, and group II consisted of 102 obesity patients. The two groups underwent IL-6 572 C/G, 190 C/T, and 174 G/C polymorphism testing, measurement of anthropometric parameters (mid-upper arm circumference and tricipital skinfold thickness), and paraclinical evaluation (protein, albumin, leptin, adiponectin, and vascular endothelial growth factor (VEGF)). We observed that phenotype CC was more frequent in obese children for IL-6 572 (p?=?0.0001), whereas CG heterozygotes were more frequent in the obese group for the IL-6 190 gene (62.7 %; p?=?0.0001). Leptin was dependent on IL-6 572 and IL-6 174 gene polymorphisms and albumin, whereas adiponectin was dependent on the IL-6 174 gene polymorphism. Body mass index (BMI), mid-upper arm circumference (MUAC), and tricipital skinfold thickness (TST) serum albumin levels correlated with C allele carriers of the IL-6 572 and IL-6 190 genes in children with obesity, whereas the CC genotype of IL-6 174 was a protective factor for obesity. Conclusion: Obesity is most frequently associated in children with IL-6 174 C allele carriers and with IL-6 190 C allele carriers. 相似文献
20.
We report a patient with respiratory failure due to expiratory central airway collapse successfully treated with airway stents. A 74-year-old male with obesity and obstructive sleep apnea had recurrent episodes of acute respiratory failure. Noninvasive positive-pressure ventilation failed because of patient intolerance and lack of improvement, and soon after he stopped using the noninvasive ventilator he developed severe respiratory failure that required a tracheostomy. He was transferred to our institution one month later. Fiberoptic bronchoscopy revealed diffuse expiratory central airway collapse of both main bronchi and the lower two thirds of the trachea, caused by bulging of the posterior airway membrane. During rigid bronchoscopy we inserted studded silicone stents in the right and left mainstem bronchi and in the distal trachea. The patient was weaned from mechanical ventilation 72 hours later and discharged to a long-term care facility. Expiratory central airway collapse should be considered in the differential diagnosis of patients with respiratory failure, especially when weaning from mechanical ventilation is difficult. 相似文献