Long-term results of closure of perforated pyloro-duodenal ulcers

Long-term results of closure of perforated ulcers were analyzed in 91 patients. Excellent and good results were obtained in 70% of the patients, in 12.1% the results were satisfactory. In 18.6% of the cases the results were considered unsatisfactory. Bad long-term results were due to the absence of dispensary follow-up, the absence of repeated courses of anti-ulcer therapy, and not following the recommendations on the treatment. Excellent and good long-term results observed in 70% of the patients allow recommendation of suturing the perforated opening and anti-ulcer therapy in patients with perforated pyloroduodenal ulcers.     

Wnt-1 expression in PC12 cells induces exon 15 deletion and expression of L-APP

The metabolism of amyloid precursor protein (APP) is central to Alzheimer's disease pathogenesis. Recent data have linked APP and presenilin to the Wnt/wingless signaling pathway. To assess affects of Wnt stimulation on APP isoform expression, we infected PC12 cells and C57MG cells with a retrovirus containing murine Wnt-1. In PC12 cells, Wnt-1 expression is associated with induction of exon 15 deletion from APP mRNA and expression of L-APP. Our data suggest that APP isoform expression is regulated, in part, by the Wnt/wingless signaling pathway.     

New assumptions in the concept of vaccine prophylaxis of infantile infections

An essential reduction in the incidence rate of six infantile infections within the Expanded Immunization Program was accompanied by occurrence of new problems in vaccine prophylaxis. 1. Vaccine-dependence--the reoccurrence of vaccine-prevented infections in those cases when vaccination was stopped. 2. A choice of strategy in the immune prophylaxis of poliomyelitis during the post-liquidation period bearing in mind the elimination of vaccine strains from the human population and a possible global refusal from vaccination. 3. Elaboration of regional programs for eliminating the measles in big territories. 4. Alteration of protective antigens Bordotella pertussis. The relationship of such alterations correlates with a rise in the Bordotella pertussis incidence rate with regard for multiple comprehensive vaccinations in the USA and Western Europe.     

Curiosine administration for management of wound process after middle ear operations in otitis media

Curiosine solution was used in surgical treatment of 80 patients with chronic otitis media purulenta early after the intervention. Otoscopic, cytological and bacteriological examinations have demonstrated that the drug creates physiological conditions for activation, migration and division of cells participating in tissue regeneration, it promotes bacterial decontamination of the wound. Curiosine can be used after radical operations on the middle ear.     

KRT-"Electron" remote control X-ray equipment complex

The paper contains data on the remote control X-ray diagnostic sets designed, in Russia, by the "Electron" Research and Instrument-Making Co. Ltd.